Chapter 1: Genome Sequence Acquisition and
Section 1.1 Defining Genomes
- What is genomics?
- How are whole genomes sequenced?
- Why do databases contain so many partial sequences?
- How do we make sense of all these bases?
- Can we predict protein functions?
- How well are genes conserved in diverse species?
- How do you know which bases form a gene?
- How many proteins can one gene make?
1.1 What is an E-value?
1.1 Which draft sequence is better?
Section 1.2 What have we
learned from the human genome draft sequences?
- Overview of human genome first draft.
- Can we describe a typical human gene?
- When are the data sufficient?
- Can the genome alter gene expression without
changing the DNA sequence?
1.2 Whose DNA did we sequence?
Chapter 2: Genome Sequence Acquisition and
Section 2.1 Evolution and
- How did eukaryotes evolve?
- What is the origin of our species?
2.1 Are the hit numbers significantly different?
2.2 How do you know if the tree is right?
Section 2.2 Genomic Identifications
- How can we identify biological weapons?
- How long can DNA survive?
- How did tuberculosis reach North America?
- How are newly emerging diseases identified?
Section 2.3 Biomedical
- Can we use genomic sequences to make new vaccines?
- Can we make new types of antibiotics?
- Can we invent new types of medications?
- How can E. coli be lethal and in our intestines
at the same time?
2.3 How can you tell if base
compositions are different?
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