LOCUS       125121        987 aa                              01-NOV-1997
DEFINITION  6-PHOSPHOFRUCTOKINASE ALPHA SUBUNIT (PHOSPHOFRUCTOKINASE 1)
            (PHOSPHOHEXOKINASE) (6PF-1-K ALPHA SUBUNIT).ACCESSION   125121
PID         g125121DBSOURCE    SWISS-PROT: locus K6P1_YEAST, accession P16861
            class: standard.            created: Aug 1, 1990.
            sequence updated: Aug 1, 1990.
            annotation updated: Nov 1, 1997.
            xrefs: gi: 172137, gi: 172138, gi: 1323434, gi: 886908, gi: 886937,
            gi: 82880
            xrefs (non-sequence databases): HSSP P00512, YEPD 5860, YEPD 5870,
            SGD L0001404, PROSITE PS00433
KEYWORDS    KINASE; TRANSFERASE; GLYCOLYSIS; REPEAT; ALLOSTERIC ENZYME;
            PHOSPHORYLATION; MAGNESIUM.SOURCE      baker's yeast.
  ORGANISM  Saccharomyces cerevisiae
            Eukaryotae; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales;
            Saccharomycetaceae; Saccharomyces.REFERENCE   1  (residues 1 to 987)
  AUTHORS   Heinisch,J., Ritzel,R.G., von Borstel,R.C., Aguilera,A., Rodicio,R.
            and Zimmermann,F.K.
  TITLE     The phosphofructokinase genes of yeast evolved from two duplication
            events  JOURNAL   Gene 78 (2), 309-321 (1989)  MEDLINE   89378757
  REMARK    SEQUENCE FROM N.A.REFERENCE   2  (residues 1 to 987)
  AUTHORS   Guerreiro,P., Azevedo,D., Barreiros,T. and Rodrigues-Pousada,C.
  TITLE     Sequencing of a 9.9 kb segment on the right arm of yeast chromosome
            VII reveals four open reading frames, including PFK1, the gene
            coding for succinyl-CoA synthetase (beta-chain) and two ORFs
            sharing homology with ORFs of the yeast chromosome VIII
  JOURNAL   Yeast 13 (3), 275-280 (1997)  MEDLINE   97245298
  REMARK    SEQUENCE FROM N.A.            STRAIN=S288C
REFERENCE   3  (residues 1 to 987)
  AUTHORS   van der Aart,Q.J., Kleine,K. and Steensma,H.Y.
  TITLE     Sequence analysis of the 43 kb
            CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm
            of Saccharomyces cerevisiae chromosome VII
  JOURNAL   Yeast 12 (4), 385-390 (1996)  MEDLINE   96267763
  REMARK    SEQUENCE OF 794-987 FROM N.A.            STRAIN=S288C
COMMENT     [CATALYTIC ACTIVITY] ATP + D-FRUCTOSE 6-PHOSPHATE = ADP +
            D-FRUCTOSE 1,6-BISPHOSPHATE.
            [PATHWAY] KEY CONTROL STEP OF GLYCOLYSIS.
            [SUBUNIT] HETEROOCTAMER OF 4 ALPHA AND 4 BETA CHAINS.
FEATURES             Location/Qualifiers     source          1..987
                     /organism="Saccharomyces cerevisiae"
                     /db_xref="taxon:4932"                     1..987
     Protein         1..987
                     /product="6-PHOSPHOFRUCTOKINASE ALPHA SUBUNIT"
                     /EC_number="2.7.1.11"ORIGIN      
        1 mqsqdscygv afrsiitnde alfkktihfy htlgfatvkd fnkfkhgens llssgtsqds
       61 lrevwlesfk lsevdasgfr ipqqeatnka qsqgallkir lvmsapidet fdtnetatit
      121 yfstdlnkiv ekfpkqaekl sdtlvflkdp mgnnitfsgl anatdsapts kdafleatse
      181 deiisrassd asdllrqtlg ssqkkkkiav mtsggdspgm naavravvrt gihfgcdvfa
      241 vyegyegllr ggkylkkmaw edvrgwlseg gtligtarsm efrkregrrq aagnlisqgi
      301 dalvvcggdg sltgadlfrh ewpslvdelv aegrftkeev apyknlsivg lvgsidndms
      361 gtdstigays alericemvd yidatakshs rafvvevmgr hcgwlalmag iatgadyifi
      421 peravphgkw qdelkevcqr hrskgrrnnt iivaegaldd qlnpvtandv kdalielgld
      481 tkvtilghvq rggtavahdr wlatlqgvda vkavleftpe tpspligile nkiirmplve
      541 svkltksvat aienkdfdka islrdtefie lyenflsttv kddgsellpv sdrlnigivh
      601 vgapsaalna atraatlycl shghkpyaim ngfsgliqtg evkelswidv enwhnlggse
      661 igtnrsvase dlgtiayyfq knkldgliil ggfegfrslk qlrdgrtqhp ifnipmclip
      721 atvsnnvpgt eyslgvdtcl nalvnytddi kqsasatrrr vfvcevqggh sgyiasftgl
      781 itgavsvytp ekkidlasir editllkenf rhdkgenrng kllvrneqas svystqllad
      841 iiseaskgkf gvrtaipghv qqggvpsskd rvtasrfavk cikfieqwnk kneaspntda
      901 kvlrfkfdth gekvptvehe ddsaavicvn gshvsfkpia nlwenetnve lrkgfevhwa
      961 eynkigdils grlklraeva alaaenk//