LOCUS HUMPLCE 4565 bp mRNA PRI 02-SEP-1996

DEFINITION Human mRNA for phospholipase C, complete cds.

ACCESSION D42108 NID g780121 KEYWORDS PLC-L (PLC-epsilon); phospholipase C.

SOURCE Homo sapiens cDNA to mRNA, clone_lib:adult brain, Hela, fetal heart clone:HOP.

ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.

REFERENCE 1 (sites)

AUTHORS Kohno,T., Otsuka,T., Takano,H., Yamamoto,T., Hamaguchi,M., Terada,M. and Yokota,J.

TITLE Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma

JOURNAL Hum. Mol. Genet. 4 (4), 667-674 (1995)

MEDLINE 95359973

REFERENCE 2 (bases 3371 to 3534)

AUTHORS Otsuka,T., Kohno,T., Mori,M., Noguchi,M., Hirohashi,S. and Yokota,J.

TITLE Deletion mapping of chromosome 2 in human lung carcinoma

JOURNAL Genes Chromosomes Cancer 16 (2), 113-119 (1996)

MEDLINE 96415751

REFERENCE 3 (bases 1 to 3370; 3235 to 4565)

AUTHORS Kohno,T.

JOURNAL Unpublished (1996)

REFERENCE 4 (bases 1 to 4565)

AUTHORS Kohno,T.

TITLE Direct Submission

JOURNAL Submitted (14-NOV-1994) to the DDBJ/EMBL/GenBank databases. Takashi Kohno, National Cancer Center Research Institute, Biology Division; 5-1-1, Tsukiji, Chuo-ku, Tokyo 104, Japan (E-mail:tkohno@gan.ncc.go.jp, Tel:03-3542-2511(ex.4651), Fax:03-3542-0807)

FEATURES Location/Qualifiers source 1..4565 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /clone="HOP" /clone_lib="adult brain, Hela, fetal heart" 5'UTR 1..203 gene 204..3197 /gene="PLC-L (PLC-epsilon)" CDS 204..3197 /gene="PLC-L (PLC-epsilon)" /codon_start=1 /product="Phospholipase C" /db_xref="PID:d1008271" /db_xref="PID:g780122" /translation="MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQ ALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYES LDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGI MLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEV YFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAI DGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYI RALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILC LGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDP DVLEGEVTDEDEEAQMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKS QNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGC QIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLA LHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDE TFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEH VTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLRE AIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYL EPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAK EGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSS SAEAKSKRSLEAIEEKESSEENGKL" 3'UTR 3198..4565 BASE COUNT 1439 a 815 c 992 g 1319 t

ORIGIN Chromosome 2. 1 gaattccggg cagcatcatc aaggcacata gattctctct ttgaacaatg cagctgctgc 61 aggggatggg gaagggatgg cactggcaat tcaagactgc ctttcctact tcttcagtgc 121 ctctttcacc aatatgaagt taaaaccagg atccttcaaa ccaaaaatgt ggtggaagaa 181 agaaaaccgt gtctttcagc agcatgccat cggaaaagaa aattagcagt gcaaatgact 241 gcatcagctt catgcaagct ggctgtgagt tgaagaaagt ccggccaaat tctcgcattt 301 acaaccgttt tttcactctg gacacagacc ttcaagctct tcgctgggaa ccttcaaaga 361 aagacctcga gaaagccaag cttgatattt ctgccataaa agagatcaga ctggggaaaa 421 acacggaaac atttacaaac aatggccttg ctgaccagat ctgtgaggac tgtgcctttt 481 ccatactcca cggggaaaac tatgagtctc tggacctagt tgccaattca gcagatgtgg 541 caaacatctg ggtgtctggg ttacggtacc tggtttctcg aagtaagcag cctcttgatt 601 ttatggaggg caaccagaac acaccacggt tcatgtggtt gaaaacagtg tttgaagcag 661 cagatgttga tgggaatggg attatgttgg aagacacctc tgtagagtta ataaaacaac 721 tcaaccctac tctgaaggaa gccaagatca ggttaaagtt taaagaaatc cagaagagca 781 aggaaaaact aaccacccgc gtgaccgaag aggaattttg tgaagctttt tgtgaacttt 841 gcaccaggcc agaagtgtat ttcttacttg tacagatatc taaaaacaaa gaatatttgg 901 atgccaatga tctcatgctc tttttagaag ctgagcaagg agtcacccat atcaccgagg 961 atatatgctt agacatcata aggagatacg aactttctga agagggacgt caaaaagggt 1021 ttcttgcaat tgatggcttt acccagtatt tattgtcatc agaatgtgac atttttgatc 1081 ctgagcaaaa gaaggttgcc caagatatga cccagccatt atctcactac tatatcaatg 1141 cctctcataa cacctatcta atagaagacc agttcagggg gccagctgac atcaatgggt 1201 acattagagc tttgaaaatg ggctgtcgaa gcgttgaact cgatgtaagt gatggttcag 1261 ataatgaacc aatcctttgt aatcgaaata acatgacaac ccatgtttcc tttcgaagtg 1321 tcatagaggt aataaataaa tttgcctttg ttgcttctga atacccactc attctttgct 1381 tgggaaatca ctgctccttg ccgcagcaga aggtaatggc tcaacagatg aaaaaggtct 1441 ttggcaataa actctatact gaagcacctt tgccctcaga atcctacctc ccatcaccag 1501 aaaaattaaa aagaatgatc attgtgaaag gaaagaagtt gccttctgat ccagatgtgt 1561 tagaaggaga agtaacagat gaagatgaag aagctcaaat gtctcgaagg atgtcggtag 1621 attacaatgg tgagcagaag caaatccgac tctgtaggga gctctctgat ttggtgtcta 1681 tttgtaaatc tgttcaatac agggattttg aactatctat gaaaagccaa aactattggg 1741 aaatgtgttc atttagtgaa acagaggcca gccgcattgc aaatgagtac ccagaggatt 1801 ttgttaatta taataagaag ttcttatcaa gaatctatcc aagtgccatg aggatcgatt 1861 ccagtaactt gaatccacag gacttttgga attgtggctg tcagattgta gcaatgaatt 1921 ttcagactcc gggtccaatg atggaccttc acacgggctg gtttcttcaa aacgggggat 1981 gtggttatgt tctaaggccg tctataatgc gagatgaagt ttcttacttc agcgcaaata 2041 caaagggcat tctacctggg gtgtctcctc tagctcttca tatcaagatc atcagtggtc 2101 agaatttccc aaagcccaag ggagcttgtg ccaaagggga tgtcatagat ccctatgttt 2161 gtatagagat acacggaatt ccagcggatt gttcggaaca aagaactaaa actgtacagc 2221 aaaacagtga taatcctatt tttgatgaaa cttttgagtt ccaagtaaac ctacctgagc 2281 tggccatgat ccgttttgtt gttctggatg atgactacat tggggatgag tttatagggc 2341 aatatacgat accatttgaa tgtttgcagc ctggatatcg gcatgttccc ctgcgttctt 2401 ttgtgggtga catcatggag cacgtaaccc tttttgtcca catagcaata actaatcgaa 2461 gtggaggagg aaaggcacag aagcgcagtc tttcagtgag aatggggaag aaagttcggg 2521 aatataccat gctcaggaat atcggtctta aaaccattga tgacatcttt aaaatagcgg 2581 ttcatccatt acgagaagcc atagatatga gagaaaatat gcagaatgca atcgtgtcta 2641 ttaaggaact atgtggactc cctccaattg ccagtctgaa gcagtgcctg ttaactctgt 2701 catctcggct catcaccagt gacaatactc cttcagtctc acttgtgatg aaagacagct 2761 ttccttacct ggagcctctg ggtgcaattc cagatgtgca gaaaaagatg ctgactgctt 2821 atgatctgat gattcaagag agccggtttc tcatagaaat ggcggacaca gtccaggaaa 2881 agattgtaca gtgtcagaaa gcagggatgg agttccatga agaacttcat aatttggggg 2941 caaaagaagg cttgaaggga agaaaactca acaaagcaac tgagagcttt gcttggaaca 3001 ttacagtatt gaagggccaa ggagatctgt tgaagaatgc caagaatgaa gctatagaaa 3061 acatgaagca gatccagctg gcatgcctgt cctgtggact gagtaaagcc cccagcagca 3121 gtgctgaggc caagagcaag cgcagcctgg aagccataga ggagaaggaa agtagtgagg 3181 agaatgggaa gctgtgactc tgggcattat cgacacgttc acccatctta tcaaggactc 3241 tggtttctca ttcttgtttt ctttctttaa atgttttata agttcacaaa atggtgccct 3301 atatggggta ttggacatag atattttcac aatgtcagta tttcagtgta gttaatttat 3361 ctaaattaaa gcctttagta tcagtgtttt aaattctgag acatgtgtca acacccctgt 3421 gtggatgcct gtggaagagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtggca 3481 gagagagaga aagagagaga gagaaattct gttaaaatct attctgtgtt gcattattca 3541 tttagtgagt tattccttga tcattttggg acaattgttt taatctgaaa ttctaaagag 3601 cacttactgt aacctgttgc tgtgtttaat ttgacttctc tgcctttgac atttaattta 3661 gtgatcttag catagcttat tattgaagga agccaaattt atcaaagcat acatgttttg 3721 gtagattaaa tatagattag aaaaattcct aagaatcaga gtagaaataa aagtgaatga 3781 aagattaaac agatgatgag aatttctaaa aagattagca aggtcatttc ttcagtcaga 3841 aaactttaaa aaatatttat taaataaaat caatttttag gaagttttct gtagtcattt 3901 actaaacata tgatttcact agaaaagctg atcataagtg aatttatacc tacctgtgtg 3961 gctactctga aacacactga aagctctgtt gcaattagga tttgatgtga cataatattg 4021 ttgtataatt tcgagatttg taggaaggtc tcattcttcc aagctgagag tctagcactc 4081 attttctata acagatatgg cagcttagag gtgttggctt tgtttggatg taattttagg 4141 ggtactaaaa tttaaaattt aaagataatt gttcaacaat atcatatcat cacattgagc 4201 tgatataaat tctgtgggtc cgataatatc tttgtgataa tttaagagct aaccagttac 4261 cacacatcta tgatataacc ctaacacaca cagaaagcat acatgcaaaa agaaatgact 4321 aattagggta catttataat tgcatctagg taatttttac cctaatgtct tcataaagta 4381 cttgagtgta atgtttgtta cctccaacag aactaaatgt tctatggtta tgaaagaata 4441 tatttattta aagcattgct tttattttga aaagcttctt aattaatttg attaacaaat 4501 atgctaattt ggggaaacct agagaagata attgttgaaa ttttgcaaat ataaacatct 4561 cctat //

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