LOCUS 1730574 1234 aa 01-NOV-1997

DEFINITION 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA 3 (PLC-BETA-3) (PHOSPHOLIPASE C-BETA-3).

ACCESSION 1730574

PID g1730574 DBSOURCE SWISS-PROT: locus PIP3_MOUSE, accession P51432 class: standard. created: Oct 1, 1996. sequence updated: Oct 1, 1996. annotation updated: Nov 1, 1997. xrefs: gi: 1150879, gi: 1150880 xrefs (non-sequence databases): MGD MGI:104778, PROSITE PS50004, PROSITE PS50007, PROSITE PS50008

KEYWORDS HYDROLASE; LIPID DEGRADATION; TRANSDUCER; CALCIUM; MEMBRANE.

SOURCE house mouse.

ORGANISM Mus musculus Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.

REFERENCE 1 (residues 1 to 1234)

AUTHORS WANG,S., ZHOU,Y., SKOGSEID,B., OBERG,K. and GOBL,A.E.

TITLE Direct Submission

JOURNAL Submitted (??-DEC-1995) TO EMBL/GENBANK/DDBJ DATA BANKS REMARK SEQUENCE FROM N.A. STRAIN=BALB/C; TISSUE=KIDNEY COMMENT [FUNCTION] THE PRODUCTION OF THE SECOND MESSENGER MOLECULES DIACYLGLYCEROL (DAG) AND INOSITOL 1,4,5-TRISPHOSPHATE (IP3) IS MEDIATED BY ACTIVATED PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C ENZYMES. [CATALYTIC ACTIVITY] 1-PHOSPHATIDYL-D-MYO-INOSITOL 4,5-BISPHOSPHATE + H(2)O = D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE + DIACYGLYCEROL. [COFACTOR] REQUIRES CALCIUM (BY SIMILARITY). [SUBCELLULAR LOCATION] MEMBRANE-BOUND (BY SIMILARITY). THERE ARE AT LEAST SIX FORMS OF PLC ENZYMES. [SIMILARITY] DOMAINS X AND Y ARE CONSERVED IN DIFFERENT FORMS OF PLC AND ARE ESSENTIAL FOR CATALYTIC ACTIVITY. [SIMILARITY] CONTAINS A COPY OF THE C2 DOMAIN. FEATURES Location/Qualifiers source 1..1234 /organism="Mus musculus" /db_xref="taxon:10090" 1..1234 Protein 1..1234 /product="1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA 3" /EC_number="3.1.4.11" Region 318..468 /note="DOMAIN X." /region_name="Domain" Site 322 /site_type="active" Site 379 /site_type="active" Region 591..707 /note="DOMAIN Y." /region_name="Domain" Region 714..811 /note="C2 DOMAIN." /region_name="Domain"

ORIGIN 1 magarpgvha lqlepstvvk tlrrgskfik wdeeassrnl vtlrvdpngf flywtgpnme 61 vdtldissir dtrtgryarl pkdpkirevl gfggpdtrle eklmtvvagp dpvnttflnf 121 mavqddtvkv wseelfklam nilaqnasrn tflrkaytkl klqvnqdgri pvknilkmfs 181 adkkrvetal escglnfnrs esirpdefpl eiferflnkl clrpdidkil leigakgkpy 241 ltleqlmdfi nqkqrdprln evlypplrss qarlliekye tnkqflerdq msmegfsryl 301 ggeengilpl ealdlsmdmt qplsayfins shntyltagq lagpssvemy rqallwgcrc 361 veldvwkgrp peeepfithg ftmttevplr dvleaiaeaa fktspypvil sfenhvdsak 421 qqakmaeycr sifgdallid pldkyplsag iplpspqdlm grilvknkkr hrpstgvpds 481 svrkrpleqs nsalsessaa tepsspqlgs pssdscpgls ngeevglekt slepqkslge 541 eslsrepnvp mpdrdredee edeeeeettd pkkpttdegt assevnatee mstlvnyvep 601 vkfksfeasr krnkcfemss fvetkameql tkspmefvey nkqqlsriyp kgtrvdssny 661 mpqlfwnvgc qlvalnfqtl dlpmqlnagv feyngrsgyl lkpefmrrpd ksfdpftevi 721 vdgivanalr vkvisgqfls dkkvgiyvev dmfglpvdtr rkyrtrtsqg nsfnpvwdee 781 pfdfpkvvlp tlaslriaaf eeggkfvghr ilpvsairsg yhyvclrnea nqplclpall 841 iyteasdyip ddhqdyaeal inpikhvslm dqrakqlaal igeseaqast etyqetpcqq 901 pgsqlpsnpt pnpldasprw ppgpttssts sslsspgqrd dliasilsev tptpleelrs 961 hkamvklrsr qdrdlrelhk khqrkavalt rrlldglaqa raegkcrpsp salgkatnse 1021 dvkeeeeakq yrefqnrqvq sllelreaqa dvetkrkleh lrqahqrlke vvldthttqf 1081 krlkelnere kkelqkildr krnnsiseak trekhkkeve lteinrrhit esvnsirrle 1141 eaqkqrherl vagqqqvlqq leeeepklla qltqecqeqr erlpqeirrc llgetaeglg 1201 dgplvacasn ghapgsgghl ssadsesqee ntql //

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