Genbank Information for the TATA Box Binding Protein of Humans (Homo sapiens)

HomoSapiens

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LOCUS 1827869 185 aa 13-FEB-1996

DEFINITION Chain A, Human Tbp Complex With Tata Element Dna Transcription Factor, Dna Binding Protein, Dna Mol_id: 1; Molecule: Human Tata Binding Protein; Chain: A; Synonym: Htbp; Engineered: Yes; Mol_id: 2; Molecule: Dna (5'-D(CpGpTpApTpApTpApTpApCpG)-3'; Chain: B, C;

Engineered: Yes. ACCESSION 1827869 PID g1827869 DBSOURCE PDB: molecule 1TGH, chain 65, release Aug 1996 deposition: Feb 13, 1996. class: Complex (Dna-Binding ProteinDNA). source: Mol_id: 1; Synthetic: Yes; Organism_scientific: Homo Sapiens; Organism_common: Human; Expression_system: T7 Rna Polymerase; Expression_system_plasmid: Pet21d; Expression_system_gene: Human Tbp; Mol_id: 2; Synthetic: Adapted From The Adenovirus E4 Promoter. Non X-ray method: X-Ray Diffraction.

KEYWORDS .

SOURCE human.

ORGANISM Homo sapiens Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.

REFERENCE 1 (residues 1 to 185)

AUTHORS Kim,J.L., Nikolov,D.B. and Burley,S.K.

TITLE Co-crystal structure of TBP recognizing the minor groove of a TATA element

JOURNAL Nature 365 (6446), 520-527 (1993)

MEDLINE 94019790

REFERENCE 2 (residues 1 to 185)

AUTHORS Kim,J.L. and Burley,S.K.

TITLE 1.9 A resolution refined structure of TBP recognizing the minor groove of TATAAAAG

JOURNAL Nat. Struct. Biol. 1 (9), 638-653 (1994)

MEDLINE 95360747

REFERENCE 3 (residues 1 to 185)

AUTHORS Z.S.Juo, T.K.Chiu, P.M.Leiberman, I.Baikalov, A.J.Berk and R.E.Dickerson.

TITLE The Structure Of The Human Tbp DNA COMPLEX, AND A Model For Tata-Box Bending And Recognition

JOURNAL Unpublished

REFERENCE 4 (residues 1 to 185)

AUTHORS Z.S.Juo and R.E.Dickerson.

TITLE Direct Submission

JOURNAL Submitted (13-FEB-1996)

COMMENT Revision History: AUG 1 96 Initial Entry.

FEATURES Location/Qualifiers source 1..185 /organism="Homo sapiens" /db_xref="taxon:9606" SecStr 9..20 /note="strand 1" /sec_str_type="sheet" SecStr 25..33 /note="helix 1" /sec_str_type="helix" SecStr 35..38 /note="strand 2" /sec_str_type="sheet" SecStr 45..51 /note="strand 3" /sec_str_type="sheet" SecStr 54..61 /note="strand 4" /sec_str_type="sheet" SecStr 63..71 /note="strand 5" /sec_str_type="sheet" SecStr 73..90 /note="helix 2" /sec_str_type="helix" SecStr 97..110 /note="strand 6" /sec_str_type="sheet" SecStr 116..124 /note="helix 3" /sec_str_type="helix" SecStr 126..129 /note="strand 7" /sec_str_type="sheet" SecStr 136..142 /note="strand 8" /sec_str_type="sheet" SecStr 145..152 /note="strand 9" /sec_str_type="sheet" SecStr 154..162 /note="strand 10" /sec_str_type="sheet" SecStr 165..181 /note="helix 4" /sec_str_type="helix"

TRANSLATION 1 gsrgsgivpq lqnivstvnl gckldlktia lrarnaeynp krfaavimri reprttalif 61 ssgkmvctga kseeqsrlaa rkyarvvqkl gfpakfldfk iqnmvgscdv kfpirleglv 121 lthqqfssye pelfpgliyr mikprivlli fvsgkvvltg akvraeiyea feniypilkg 181 frktt //