LOCUS 584899 861 aa 01-NOV-1997

DEFINITION ACTIVATOR 1 95 KD SUBUNIT (REPLICATION FACTOR C 95 KD SUBUNIT) (CELL DIVISION CONTROL PROTEIN 44).

ACCESSION 584899 PID g584899 DB

SOURCE SWISS-PROT: locus RFC1_YEAST, accession P38630 class: standard. created: Oct 1, 1994. sequence updated: Oct 1, 1994. annotation updated: Nov 1, 1997. xrefs: gi: 437273, gi: 437274, gi: 841461, gi: 841462, gi: 1050762, gi: 1050769, gi: 1420504, gi: 626116 xrefs (non-sequence databases): SGD L0000278

KEYWORDS DNA REPLICATION; ATP-BINDING; NUCLEAR PROTEIN; DNA-BINDING; CELL DIVISION; CELL CYCLE.

SOURCE baker's yeast.

ORGANISM Saccharomyces cerevisiae Eukaryotae; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

REFERENCE 1 (residues 1 to 861) AUTHORS Howell,E.A., McAlear,M.A., Rose,D. and Holm,C.

TITLE CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C

JOURNAL Mol. Cell. Biol. 14 (1), 255-267 (1994) MEDLINE 94088522

REMARK SEQUENCE FROM N.A. STRAIN=S288C REFERENCE 2 (residues 1 to 861)

AUTHORS Cullmann,G., Fien,K., Kobayashi,R. and Stillman,B.

TITLE Characterization of the five replication factor C genes of Saccharomyces cerevisiae

JOURNAL Mol. Cell. Biol. 15 (9), 4661-4671 (1995) MEDLINE 95379808 REMARK SEQUENCE FROM N.A. STRAIN=S288C

REFERENCE 3 (residues 1 to 861) AUTHORS Galisson,F. and Dujon,B.

TITLE Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae

JOURNAL Yeast 12 (9), 877-885 (1996) MEDLINE 96437977

REMARK SEQUENCE FROM N.A. STRAIN=S288C / FY1679 COMMENT [FUNCTION] THE ELONGATION OF PRIMED DNA TEMPLATES BY DNA POLYMERASE DELTA AND EPSILON REQUIRES THE ACTION OF THE ACCESSORY PROTEINS PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND ACTIVATOR 1. THE 95 KD SUBUNIT IS ESSENTIAL FOR CELL CYCLE PROGRESSION. IT MAY ASSOCIATE WITH COMPONENTS OF THE DNA REPLICATION MACHINERY AND SERVE TO ENHANCE THE EFFICENCY OF DNA REPLICATION. [SUBUNIT] HETEROPENTAMER OF SUBUNITS OF 95, 41, 40, AND 37 KD THAT FORMS A COMPLEX WITH PCNA IN THE PRESENCE OF ATP. [SUBCELLULAR LOCATION] NUCLEAR (PROBABLE). [SIMILARITY] TO MAMMALIAN AC1 140 KD SUBUNIT.

FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae" /db_xref="taxon:4932" 1..861 Protein 1..861 /product="ACTIVATOR 1 95 KD SUBUNIT" Region 152..224 /note="TO NAD-DEPENDENT DNA LIGASES." /region_name="Similarity" Site 353..360 /note="ATP." /site_type="np-binding" Site 427 /note="D->H: IN CS MUTANT CDC44-2;

CAUSES CELL CYCLE ARREST." /site_type="mutagenized" Site 436 /note="G->R: IN CS MUTANT CDC44-3/4; CAUSES CELL CYCLE ARREST." /site_type="mutagenized" Site 512 /note="G->A: IN CS MUTANT CDC44-9; NO EFFECT." /site_type="mutagenized" Site 513 /note="D->N: IN CS MUTANTS CDC44-1/5/8 AND CDC44-9

CAUSES CELL CYCLE ARREST." /site_type="mutagenized" Region 830..834 /note="NUCLEAR LOCALIZATION SIGNAL." /region_name="Domain" Region 855..860 /note="NUCLEAR LOCALIZATION SIGNAL." /region_name="Domain"

ORIGIN 1 mvnisdffgk nkksvrssts rptrqvgssk pevidldtes dqestnktpk kmpvsnvidv

61 setpegekkl plpakrkass ptvkpasskk tkpsskssds asnitaqdvl dkipsldlsn

121 vhvkenakfd fksansnadp deivseigsf pegkpncllg ltivftgvlp tlergaseal

181 akrygarvtk sissktsvvv lgdeagpkkl ekikqlkika ideegfkqli agmpaeggdg

241 eaaekarrkl eeqhniatke aellvkkeee rskklaatrv sgghlerdnv vreedklwtv

301 kyaptnlqqv cgnkgsvmkl knwlanwens kknsfkhagk dgsgvfraam lygppgigkt

361 taahlvaqel gydileqnas dvrsktllna gvknaldnms vvgyfkhnee aqnlngkhfv

421 iimdevdgms ggdrggvgql aqfcrktstp lilicnernl pkmrpfdrvc ldiqfrrpda

481 nsiksrlmti airekfkldp nvidrliqtt rgdirqvinl lstistttkt inhenineis

541 kaweknialk pfdiahkmld gqiysdigsr nftlndkial yfddfdftpl miqenylstr

601 psvlkpgqsh leavaeaanc islgdivekk irsseqlwsl lplhavlssv ypaskvaghm

661 agrinftawl gqnsksakyy rllqeihyht rlgtstdkig lrldylptfr krlldpflkq

721 gadaissvie vmddyyltke dwdsimeffv gpdvttaiik kipatvksgf trkynsmthp

781 vaiyrtgsti ggggvgtsts tpdfedvvda ddnpvpadde etqdsstdlk kdklikqkak

841 ptkrktatsk pggskkrktk a //

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