LOCUS       HUMTPI       1835 bp    mRNA            PRI       07-AUG-1995
DEFINITION  Human triosephosphate isomerase mRNA, complete cds.
ACCESSION   M10036 M10037NID         g339840
KEYWORDS    triose-phosphate isomerase.
SOURCE      Human adult liver, cDNA to mRNA, clone pHTPI-5a [3],[2]; DNA, clone
            lambda-hTPI-8B [3].  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases )  AUTHORS   Maquat,L.  JOURNAL   Unpublished (1985)
REFERENCE   2  (bases 369 to 1562)
  AUTHORS   Maquat,L.E., Chilcote,R. and Ryan,P.M.
  TITLE     Human triosephosphate isomerase cDNA and protein structure. Studies
            of triosephosphate isomerase deficiency in man
  JOURNAL   J. Biol. Chem. 260 (6), 3748-3753 (1985)  MEDLINE   85131186
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Brown,J.R., Daar,I.O., Krug,J.R. and Maquat,L.E.
  TITLE     Characterization of the functional gene and several processed
            pseudogenes in the human triosephosphate isomerase gene family
  JOURNAL   Mol. Cell. Biol. 5 (7), 1694-1706 (1985)  MEDLINE   85267686
COMMENT     Draft entry and sequence in computer-readable form [3],[2] kindly
            provided by L.Maquat, 30-JUL-1985.
            The variations annotated in the FEATURES table are silent and
            probably occurred because the DNA for sequencing was obtained from
            different individuals.            [1]  revision.
FEATURES             Location/Qualifiers     source          1..1835
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"                     /map="12p13"
     mRNA            334..1562                     /note="TPI mRNA"
     gene            368..1117                     /gene="TPI1"
     CDS             368..1117                     /gene="TPI1"
                     /note="triosephosphate isomerase (EC 5.3.1.1)"
                     /codon_start=1
                     /db_xref="GDB:G00-119-617"
                     /db_xref="PID:g339841"
                     /translation="MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAP
                     PTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHV
                     FGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSK
                     VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATC
                     KELASQPDVDGFLVGGASLKPEFVDIINAKQ"     variation       652
                     /gene="TPI1"                     /note="a in [2]; g in [3]"
                     /replace="g"     old_sequence    856
                     /gene="TPI1"                     /citation=[2]
BASE COUNT      399 a    495 c    541 g    400 t
ORIGIN      261 bp upstream of NcoI site; chromosome 12.
        1 accagctagt tccgcttgaa aaccacttct ggccccgtgg gggactcaag tcgccaagcg
       61 agggttcccc tgagcgccgg agctcacagg tctcgccttg tcccgaaagc cccgcaatcg
      121 aggcggaggc gaccgagccc ccgactctcc tagaacgttg ccacaagaag ggggaacgtc
      181 ggaacagtgc atcatcgggc ggcggccggg gcggcggcag gagggcgggc ggggggcagg
      241 gctccggggg actgggcggg ccatggcgga ggacggcgag gaggcggagt tccacttcgc
      301 ggcgctctat ataagtgggc agtggccgac tgcgcgcgac actgaccttc agcgcctcgg
      361 ctcggccatg gcgccctcca ggaagttctt cgttggggga aactggaaga tgaacgggcg
      421 gaagcagagt ctgggggagc tcatcggcac tctgaacgcg gccaaggtgc cggccgacac
      481 cgaggtggtt tgtgctcccc ctactgccta tatcgacttc gcccggcaga agctagatcc
      541 caagattgct gtggctgcgc agaactgcta caaagtgact aatggggctt ttactgggga
      601 gatcagccct ggcatgatca aagactgcgg agccacgtgg gtggtcctgg gacactcaga
      661 gagaaggcat gtctttgggg agtcagatga gctgattggg cagaaagtgg cccatgctct
      721 ggcagaggga ctcggagtaa tcgcctgcat tggggagaag ctagatgaaa gggaagctgg
      781 catcactgag aaggttgttt tcgagcagac aaaggtcatc gcagataacg tgaaggactg
      841 gagcaaggtc gtcctcgcct atgagcctgt gtgggccatt ggtactggca agactgcaac
      901 accccaacag gcccaggaag tacacgagaa gctccgagga tggctgaagt ccaacgtctc
      961 tgatgcggtg gctcagagca cccgtatcat ttatggaggc tctgtgactg gggcaacctg
     1021 caaggagctg gccagccagc ctgatgtgga tggcttcctt gtgggtggtg cttccctcaa
     1081 gcccgaattc gtggacatca tcaatgccaa acaatgagcc ccatccatct tccctaccct
     1141 tcctgccaag ccagggacta agcagcccag aagcccagta actgcccttt ccctgcatat
     1201 gcttctgatg gtgtcatctg ctccttcctg tggcctcatc caaactgtat cttcctttac
     1261 tgtttatatc ttcaccctgt aatggttggg accaggccaa tcccttctcc acttactata
     1321 atggttggaa ctaaacgtca ccaaggtggc ttctccttgg ctgagagatg gaaggcgtgg
     1381 tgggatttgc tcctgggttc cctaggccct agtgagggca gaagagaaac catcctctcc
     1441 cttcttacac cgtgaggcca agatcccctc agaaggcagg agtgctgccc tctcccatgg
     1501 tgcccgtgcc tctgtgctgt gtatgtgaac cacccatgtg agggaataaa cctagcacta
     1561 ggtcttgtgg tttgtctgcc ttcactggac ttgcccagat aatcttcctt tttgaggcag
     1621 ctatataaat gatcatttgt gcaagaaaaa aaaaaaaaca agaacaggtt tctataacaa
     1681 catctcttac tatttttact tgaaaaaatg ttttgcgtag cagactgtca tagccttgaa
     1741 cgccggctcc ctttcttcct ccctccaagt ggctctgggg ctgttgattt ccgcagagct
     1801 gggttggggt aggggctcag cccaccagct ttcag//