LOCUS 129368 367 aa 01-NOV-1997
DEFINITION CELLULAR TUMOR ANTIGEN P53.
ACCESSION 129368
PID g129368
DBSOURCE SWISS-PROT: locus P53_CHICK, accession P10360
class: standard.
created: Mar 1, 1989.
sequence updated: Mar 1, 1989.
annotation updated: Nov 1, 1997.
xrefs: gi: 63740, gi: 63741, gi: 86220
xrefs (non-sequence databases): HSSP P04637, PROSITE PS00348
KEYWORDS ANTI-ONCOGENE; DNA-BINDING; TRANSCRIPTION REGULATION; ACTIVATOR;
NUCLEAR PROTEIN; PHOSPHORYLATION; APOPTOSIS.
SOURCE chicken.
ORGANISM Gallus gallus
Eukaryotae; Metazoa; Chordata; Vertebrata; Archosauria; Aves;
Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (residues 1 to 367)
AUTHORS Soussi,T., Begue,A., Kress,M., Stehelin,D. and May,P.
TITLE Nucleotide sequence of a cDNA encoding the chicken p53 nuclear
oncoprotein
JOURNAL Nucleic Acids Res. 16 (23), 11383 (1988)
MEDLINE 89083584
REMARK SEQUENCE FROM N.A.
STRAIN=SPAFA
COMMENT [FUNCTION] ACT AS A TUMOR SUPPRESSOR IN MANY TUMOR TYPES. INDUCES
GROWTH ARREST OR APOPTOSIS DEPENDING ON THE PHYSIOLOGICAL
CIRCUMSTANCES OR CELL TYPE, BUT BOTH ACTIVITIES ARE INVOLVED IN
TUMOR SUPPRESSION. IT ACTS IN CELL CYCLE REGULATION, IT IS A
TRANS-ACTIVATOR THAT ACTS TO NEGATIVELY REGULATE CELLULAR DIVISION
BY CONTROLLING A SET OF GENES REQUIRED FOR THIS PROCESS. ONE OF THE
GENES ACTIVATED IS AN INHIBITOR OF CYCLIN-DEPENDENT KINASES.
APOPTOSIS INDUCTION SEEMS TO BE MEDIATED EITHER BY STIMULATION OF
BAX AND FAS ANTIGEN EXPRESSION, OR BY REPRESSION OF BCL-2
EXPRESSION (BY SIMILARITY).
[SUBCELLULAR LOCATION] NUCLEAR.
[SIMILARITY] STRONG, TO P53 IN OTHER HIGHER EUKARYOTES.
FEATURES Location/Qualifiers
source 1..367
/organism="Gallus gallus"
/db_xref="taxon:9031"
1..367
Protein 1..367
/product="CELLULAR TUMOR ANTIGEN P53"
Region 289..302
/note="NUCLEAR LOCALIZATION SIGNAL."
/region_name="Domain"
Site 366
/site_type="phosphorylation"
ORIGIN
1 maeemeplle ptevfmdlws mlpysmqqlp lpedhsnwqe lsplepsdpp ppppppplpl
61 aaaappplnp ptppraapsp vvpstedygg dfdfrvgfve agtaksvtct yspvlnkvyc
121 rlakpcpvqv rvgvapppgs slravavykk sehvaevvrr cphhercggg tdglapaqhl
181 irvegnpqar yhddettkrh svvvpyeppe vgsdcttvly nfmcnsscmg gmnrrpilti
241 ltlegpggql lgrrcfevrv cacpgrdrki eeenfrkrgg aggvakrams ppteapeppk
301 krvlnpdnei fylqvrgrrr yemlkeinea lqlaeggsap rpskgrrvkv egpqpscgkk
361 llqkgsd
//

the above report in format