LOCUS 129373 396 aa 01-NOV-1997
DEFINITION CELLULAR TUMOR ANTIGEN P53 (TUMOR SUPPRESSING PROTEIN).
ACCESSION 129373
PID g129373
DBSOURCE SWISS-PROT: locus P53_SALIR, accession P25035
class: standard.
created: May 1, 1992.
sequence updated: May 1, 1992.
annotation updated: Nov 1, 1997.
xrefs: gi: 213828, gi: 213829, gi: 85560
xrefs (non-sequence databases): HSSP P04637, PROSITE PS00348
KEYWORDS ANTI-ONCOGENE; DNA-BINDING; TRANSCRIPTION REGULATION; ACTIVATOR;
NUCLEAR PROTEIN; PHOSPHORYLATION; APOPTOSIS.
SOURCE rainbow trout.
ORGANISM Oncorhynchus mykiss
Eukaryotae; Metazoa; Chordata; Vertebrata; Actinopterygii;
Neopterygii; Teleostei; Euteleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Oncorhynchus.
REFERENCE 1 (residues 1 to 396)
AUTHORS Caron de Fromentel,C., Pakdel,F., Chapus,A., Baney,C., May,P. and
Soussi,T.
TITLE Rainbow trout p53: cDNA cloning and biochemical characterization
JOURNAL Gene 112 (2), 241-245 (1992)
MEDLINE 92210006
REMARK SEQUENCE FROM N.A.
COMMENT [FUNCTION] ACT AS A TUMOR SUPPRESSOR IN MANY TUMOR TYPES. INDUCES
GROWTH ARREST OR APOPTOSIS DEPENDING ON THE PHYSIOLOGICAL
CIRCUMSTANCES OR CELL TYPE, BUT BOTH ACTIVITIES ARE INVOLVED IN
TUMOR SUPPRESSION. IT ACTS IN CELL CYCLE REGULATION, IT IS A
TRANS-ACTIVATOR THAT ACTS TO NEGATIVELY REGULATE CELLULAR DIVISION
BY CONTROLLING A SET OF GENES REQUIRED FOR THIS PROCESS. ONE OF THE
GENES ACTIVATED IS AN INHIBITOR OF CYCLIN-DEPENDENT KINASES.
APOPTOSIS INDUCTION SEEMS TO BE MEDIATED EITHER BY STIMULATION OF
BAX AND FAS ANTIGEN EXPRESSION, OR BY REPRESSION OF BCL-2
EXPRESSION (BY SIMILARITY).
[SUBCELLULAR LOCATION] NUCLEAR.
[SIMILARITY] STRONG, TO P53 IN OTHER HIGHER EUKARYOTES.
FEATURES Location/Qualifiers
source 1..396
/organism="Oncorhynchus mykiss"
/db_xref="taxon:8022"
1..396
Protein 1..396
/product="CELLULAR TUMOR ANTIGEN P53"
Region 302..318
/note="NUCLEAR LOCALIZATION SIGNAL."
/region_name="Domain"
Site 395
/site_type="phosphorylation"
ORIGIN
1 madlaenvsl plsqesfedl wkmnlnlvav qppeteswvg ydnfmmeapl qvefdpslfe
61 vsatepapqp sistldtgsp ptstvpttsd ypgalgfqlr flqsstaksv tctyspdlnk
121 lfcqlaktcp vqivvdhppp pgavvralai ykklsdvadv vrrcphhqst sennegpapr
181 ghlvrvegnq rseymedgnt lrhsvlvpye ppqvgsectt vlynfmcnss cmggmnrrpi
241 ltiitletqe gqllgrrsfe vrvcacpgrd rkteeinlkk qqettletkt kpaqgikram
301 keaslpapqp gaskktkssp avsddeiytl qirgkekyem lkkfndslel selvpvadad
361 kyrqkcltkr vakrdfgvgp kkrkkllvke eksdsd
//