LOCUS DROCHD1A 6242 bp mRNA INV 13-AUG-1996

DEFINITION Drosophila melanogaster chromodomain-helicase-DNA-binding (CHD-1) mRNA, complete cds.

ACCESSION L77907 NID g1448982

KEYWORDS ATPase/helicase domain; DNA-binding domain; chromatin; chromodomain; chromodomain-helicase-DNA-binding protein.

SOURCE Drosophila melanogaster (clone library: Brown and Kafatos 1988) embryonic cDNA to mRNA.

ORGANISM Drosophila melanogaster

Eukaryotae; mitochondrial eukaryotes; Metazoa; Arthropoda; Tracheata; Insecta; Pterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.

REFERENCE 1 (bases 1 to 6242)

AUTHORS Stokes,D.G., Tartof,K.D. and Perry,R.P.

TITLE CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes

JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (14), 7137-7142 (1996)

MEDLINE 96293489

COMMENT Molecule sequenced changed to 'ss-mRNA' after discussion with Gustavo Seluca; he found a reference to the cDNA library used (J Mol Biol 203: 425-37 (1988)).

FEATURES Location/Qualifiers source 1..6242 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /clone_lib="Brown and Kafatos 1988" /dev_stage="embryonic" mRNA 1..6242 /gene="Chd1" /db_xref="FlyBase:FBgn0016132" 5'UTR <1..109 /gene="Chd1" /db_xref="FlyBase:FBgn0016132" gene 1..6242 /note="Chromodomain-helicase-DNA-binding protein" /gene="Chd1" /allele="" /db_xref="FlyBase:FBgn0016132" CDS 110..5761 /gene="Chd1" /codon_start=1 /product="chromodomain-helicase-DNA-binding protein" /db_xref="PID:g1448983" /

translation="MSQALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSD SDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGS DSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDS SANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDE SEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGA AVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCT GNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMK AKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSK PDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKY RPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICF LYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQ FESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDT NHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGHTRLHQQLEPY ILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNI VIELKKCCNHAALIRPSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVL IFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRA GGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVE RAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDE QEHDDDLVCDIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQN AAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGG KGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKF PAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGA KQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVF DVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEY LLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTV AESSNSQVDPSNASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNKPMHFTANN EPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGK QIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKD KGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYA DPPLKRKRDENDADASSGLAGAPGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYG GSGPPMGSGSYEGGSNSRSQGPTSPSTPRTGRGGYDPPPAPSGYTPEMERWQSRDRYS QDYKRDRYDGYGRSGGGQGIYHRERDRRPEKRRYPSGLPPHPYSSHYLPPNYYGLPNG AVPGLPPPSSVYRSDPRGYPVMPRDYPADYRRSDYERRTQT"

misc_feature 1130..1310 /gene="Chd1" /standard_name="chromo domain" /db_xref="FlyBase:FBgn0016132" misc_feature 1682..3067 /gene="Chd1" /standard_name="ATPase/helicase domain" /db_xref="FlyBase:FBgn0016132" misc_feature 3566..4282 /gene="Chd1" /standard_name="DNA-binding domain" /db_xref="FlyBase:FBgn0016132" 3'UTR 5762..>6242 /gene="Chd1" /db_xref="FlyBase:FBgn0016132"

BASE COUNT 1677 a 1678 c 1761 g 1126 t

ORIGIN

1 aagtgggcag cgggaaaaac ataaacattc gccagcgacc gcatgcaagt gagccccctg 61 tatttaatga gcgctacaag gcaactgtgt gtgctaccac gacaatataa tgagccaggc 121 actcaatgaa tcggcgaata gtattggctc agacgaacaa gatgacactc gggaagaggc 181 caatggcacc gaccatagtg gcagtggcag cggtagtggc tcctccggct cagactcaga 241 ttcagacagc tcctcgggca actctagcga tggacggagc tccccagaac ccgaggacaa 301 atcgttatcg gtggcagggt ttccaccgac agccgctgct gcccaggcgg acagtaagac 361 gaacgggttc acggatgacc aggaggacag ctccagtgac gggtctagtg gcagtgattc 421 cgattcagac gccgagggcc catcggatca aaggaaccag agcatcaaca atgccaacac 481 aagcagcagt ttgcctaagc cggagcagaa tgaggaggag gacaatgaga ctgaggctgg 541 tcagcagcag ccagccagcg atgcctctgc cgatgaatca agtgatagtt ctgccaatgt 601 gtcacccaca tcctccagca gcagcagtga ggaggaagag gaggactata gacccaagcg 661 gacgcgccag gcgcgcaaac caccgactgc tgctgagaag tccaaaaaag ctccagcacc 721 caagaacaag aagaaaacct gggactcgga tgaaagcgat gaaagcgagg acagtgatga 781 cgaggtgtcc accgcccaaa agcgcaaacc ggcagcaact acctctcgca gcaaactcgc 841 acagcaacag cagcggcgca gggtgaaacc ctttagttcc gaggacagtg atgatgacga 901 cgctagcaaa cgctgcgcta ctcgtcgcaa gggtgctgcc gttagctaca aggaggcttc 961 ggaggacgaa gccaccgact ccgaggatct gctggagttt gagtacgatg aaagccaggc 1021 agccaccact gccgctacgg ctgaggagga ggaaaagtgc gaaaccatag agcgtatcct 1081 ggcgcagcgt gctgggaaga ggggatgcac gggcaatcag acaacgatct atgcaataga 1141 ggaaaacggc tttgatccac atgctggatt tgatgaaaag caaactccag acgcggagac 1201 cgaggcacag ttcctgatca agtggaaggg ctggtcgtac atccacaaca cctgggaatc 1261 tgaggctacc ctgcgtgata tgaaggccaa gggaatgaag aagctggata acttcatcaa 1321 aaaggagaag gaacaggcct actggcgccg atacgctggc cccgaggaca tcgactactt 1381 cgagtgtcag ctggaactgc agcatgagct actgaaatcg tacaacaacg tggaccgaat 1441 cattgccaag ggctctaagc cagacgacgg caccgaggag tacctgtgca aatggcagtc 1501 gctaccgtac gccgagtcca catgggagga tgccgccctg gttcttcgca agtggcaacg 1561 ctgcgcagag caattcaatg accgcgagtc ctccaaatgc actccctccc gccactgcag 1621 agtgatcaag tatcgcccca agttctctcg aataaagaat cagccggaat ttctttcgtc 1681 gggcctaact ctaagggatt accaaatgga cggcctgaat tggctgctgc actcatggtg 1741 caaggagaac tcggtgatcc tggccgacga gatgggcctc ggcaagacca tccaaactat 1801 ttgcttcctg tactcgctgt tcaagatcca tcacctgtac ggcccgttcc tgtgcgtggt 1861 gccacttagc acaatgacgg cctggcagcg ggagttcgac ctgtgggcgc cggacatgaa 1921 tgtagtcacg tacctcggag acattaaatc ccgcgagctc attcaacagt acgaatggca 1981 gtttgagagc tccaagcggc ttaaattcaa ttgcattctc acaacgtacg agattgtgct 2041 caaggataaa caatttctgg gcacgcttca gtgggctgcg ctcctggtgg acgaagcgca 2101 tcgtcttaag aacgacgact cactgctcta caagtcgctg aaggagtttg acactaacca 2161 tcgactgctc ataacaggta ccccgctgca gaattcgctg aaggagctct gggctttgct 2221 gcacttcatc atgccggata agtttgacac gtgggagaat ttcgaggtgc agcatggcaa 2281 tgcggaggac aagggccaca ctcggttgca tcaacagctg gagccgtata ttctgcggag 2341 agtgaagaag gatgtggaga aatcgctgcc ggctaaagtg gagcagatcc tgcgggtcga 2401 gatgacctct ctgcagaaac agtactacaa gtggatccta accaaaaact ttgatgcact 2461 gcgcaaggga aagcggggca gtacctccac tttcctcaac atagtcatcg agctaaagaa 2521 gtgttgcaac cacgcggctc tcatccggcc atccgagttt gagcttatgg gtctgcagca 2581 ggatgaggca ttgcaaactc ttcttaaggg atccggaaag cttgtgctgc tcgataagct 2641 actctgccga ctgaaagaga cgggccaccg cgtgctgatt ttttcccaaa tggtgcgcat 2701 gctggacgtt ctggctgact atctgcagaa gcgtcacttc cctttccagc gcctcgacgg 2761 cagcataaag ggagagatga ggcgccaggc tctggatcac ttcaatgcag agggtagcca 2821 ggacttttgc ttcctgctct cgacaagggc tggtggattg ggcattaact tggccacagc 2881 cgatactgtt attatctttg actccgactg gaacccccaa aacgatttac aggcgcaggc 2941 gagagcgcat cgaatcggtc agaaaaacca ggttaacatt tatcgcctgg tcactgcccg 3001 gtcggtggag gaacagatcg tggagcgagc caaacagaaa atggtgctgg accacctggt 3061 cattcagcgg atggacacta caggacgcac tgttctggat aagagcggca acgggcactc 3121 gtctaactcg aatccgttca acaaggacga tctttctgct atcctgaagt ttggtgcaga 3181 ggagctgttc aaggacgaac aggagcatga cgatgacttg gtttgtgaca ttgatgaaat 3241 tctgcgcagg gcggagaccc gcaacgaaga tccggaaatg ccagcagacg acttgttgtc 3301 cgccttcaaa gtggccagca tagctgcttt cgaagaggaa ccgagcgatt cggttagcaa 3361 gcaggaccaa aatgccgccg gcgaggagga tgacagtaag gactgggacg acatcattcc 3421 ggaaggcttc cgtaaagcaa tcgacgatca ggagcgagcc aaagagatgg aagatctcta 3481 cttgccacct cggaggaaaa ctgccgctaa ccaaaacgaa gggaagcgtg gagctggcaa 3541 ggggggcaag gggaaacagc aggcagacga ctccggtggc gactcggatt acgagctggg 3601 ctccgacggc agtggtgacg atggacgacc tcgcaagcgc gggcggccga ccatgaagga 3661 gaagatcacc ggattcacgg atgcggagtt gcgtcgcttc attcgcagtt acaaaaagtt 3721 tcccgctcct ctccaccgca tggaggccat cgcatgtgat gctgagctgc aggaaaagcc 3781 actggcggaa ctgaagcgcc tcggagagat gctgcatgac cgctgcgttc agttcctgca 3841 cgagcacaag gaggaagaga gtaagactgc ggcgacggat gagacgccgg gcgccaagca 3901 gcgccgcgca cgcgccacct tctccgttaa gctgggtggt gtctccttta atgccaaaaa 3961 gctgctggcc tgcgaacagg agcttcagcc gctcaacgag atcatgccca gcatgcccga 4021 agagcgccag caatggagct tcaatatcaa gacacgcgcc ccggtcttcg acgtggattg 4081 gggcatcgag gaggacacga agctactgtg cggcatttac cagtacggca ttggatcctg 4141 ggagcaaatg aagctagacc ccacgctcaa actgaccgac aagattttgc ttaacgatac 4201 gcgcaagccc caggccaagc agctgcagac gcgtgccgag tacctgctca agatcatcaa 4261 gaagaacgtg gagctgacca agggaggaca acgccgacaa cggcgcccca gagcatcgcg 4321 agctaacgat gccaaggcgg caagccagtc tgctagttcg accatcgatg ctaagccgca 4381 cgatggcgag gacgctgctg gcgacgcacg caccgtcgcc gaaagcagta acagtcaagt 4441 agatccatct aacgcgtcgc cgcacaatgc tccagctacg gaacagcacg gtgaccctgc 4501 gaagaaagcc aaaaaatcca aggctcgttc gaagaaaacc agcgcctcgg acaacaacgg 4561 caacaagccg atgcacttta cggcgaacaa tgaacctagg gctttggagg tcctgggtga 4621 cctagatccc agcattttta acgagtgcaa agaaaaaatg cggccggtga agaaggccct 4681 caaggcgctg gaccagccgg atgtcagtct ttccgaccag gatcagctgc agcacacgag 4741 ggattgcctg cttcaaattg gcaagcagat cgatgtttgc ctcaatccct acgccgagac 4801 agagaaaaag gaatggcgca gtaacctttg gtactttgtg tcgaaattca ctgagctgga 4861 tgccaagcgc ctattcaaga tttacaaaca cgcactcaag cagaaagcgg gcggcgatgg 4921 cgaggcgaag ggaaaagaca agggctcgtc aggaagtccg gccaagtcta aacccaacgg 4981 tgtgactact gaagaaaaag aaaaggagcg cgacaggagt gggggcaaaa agaagaaaaa 5041 ggacaaggac aaggaacgca gtggacaggc gcggtatccg gaaacgggta tacccacctc 5101 cggtcgttac gctgaccctc ccctaaagcg taagcgggat gagaacgacg ctgatgcaag 5161 cagcggacta gcaggtgccc ccggcggagg catcggcgac aacctcaagt ccatgtcctt 5221 caaacggctg aacatggacc gtcacgagga ccgtaagaag caccatcgcg gtcccgacta 5281 ctacggtggc agtggcccac ccatgggaag tggtagctac gaaggcggca gcaattcccg 5341 gagccagggc cccacctccc catctacacc ccgtactggc cggggcggct atgatccacc 5401 gcccgcgcca tccggctaca cgccggaaat ggagcgatgg caatcccgcg atagatacag 5461 ccaggattac aaacgggatc gctacgatgg atatgggcgc agtgggggag gtcaaggcat 5521 ctatcatcgc gaacgcgacc gtcgtcccga gaagcgcaga tatccgtctg gcttgccacc 5581 gcatccttac tcaagccact acctgccgcc caattactat ggattgccta atggagccgt 5641 tccgggccta ccgccaccgt cgtctgtcta ccgcagtgac ccacgcggat atccggtcat 5701 gccgcgagac tatcctgccg actacagacg cagcgactac gagcggcgca cgcagacctg 5761 aggagtcagc tctgggggcc gactgtcgat tgtacataaa acacttagac ttaagcccgg 5821 ctggcgggcc atcgtgtcct ggccagccac tcgacacagt aaaaccaacc cgcatacagt 5881 acgttaagcg tagctccata cacctgtaca agtaattcct agcagctaac tatacttcta 5941 taaatgacta tacatccgat cgcacagagg gccggcattg catcatccag ggtttagtgg 6001 caatacctgc aacctaatct tagactttcc gtgtataaat cgtagcgtaa ggctttaact 6061 cgtccttcat cattgcggaa catcgttttt atactggcca actgcacgga agatgcggct 6121 ggctgcgaat gcatgctgtg tggtttatta ggtggcccac ggtgcgaacc agtcgttcaa 6181 aagcttttaa accaacaaca aattctcact atatttaaac actatcatca tatgattgta 6241 aa //