This web page was produced as an assignment for an undergraduate course at Davidson College.
This web page assignment is a more specific version of the last assignment. My "favorite" protein is isocitrate dehydrogenase 1 (IDH-1). I will try to find othologs for IDH-1 from 5 other species. Isocitrate dehydrogenase is an enzyme that is involved in the citric acid cycle of some organisms. In the citric acid cycle, it functions by catalyzing the oxidative decarboxylation of isocitrate to a-ketoglutarate and carbon dioxide. Some forms of IDH use NAD+ as a coenzyme, while others use NADP+. The product of this step in the citric acid cycle, a-ketoglutarate, is also the precursor for certain amino acids. So, even in organisms that do not use the citric acid cycle, isocitrate dehydrogenase is important. (Source: <http://www.csb.ki.se/xray/idh.html>
If you have any questions or comments about this web page, please e-mail me, Chris Norbet