This web page was produced by Zack Perfect as an assignment for an undergraduate course at Davidson College

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Below are cDNA and amino acid sequences for IDH gene orthologs in different species, which when compared may give insight into the evolutionary history via the changes or conservation of aspects of the gene of interest surviving speciation events. Feel free to compare and contrast the sequences and explain what evolutionary significance you've found. Yes, I could have summarized the entire IDH sequence lineage and role over millennia in a few short sentences, but at some point you have start thinking for yourself.


Sinorhizobium meliloti


Thale Cress (Arabidopsis thaliana)


Norway Rat (Rattus norvegicus)


Cow (Bos taurus)


Human (Homo sapiens)



If you have the option to play basketball or look up orthologs on a warm, spring afternoon I suggest the former, but if you're looking for something to do, searching for orthologs of your favorite protein can be a BLAST.