3D Structure of HRDC domain of RecQ Helicase
CPK Color Scheme
RecQ Helicases are a family of 3'-5' exonucleases that maintain genomic stability. Mutations in RecQ Helicases can cause Bloom's, Werner's, or Rothmund-Thomson Syndrome. RecQ Helicases share highly conserved domains, including the Helicase RNaseD C-terminus domain, or the HRDC domain.
Click here to learn more about the RecQL3 Helicase involved in Bloom's syndome
BLM gene encodes RecQ Helicase
This tutorial describes the structure of the HRDC domain. The HRDC domain is thought to contribute to the auxiliary molecular interactions of RecQ Helicases by binding with DNA in a non-specific manner.