C O N P S
Coagulation Factor IX is an important protein in the blood clotting cascade. In humans, Factor IX forms a complex with Factor VIII to activate Factor X. The eventual outcome, after the action of 13 important proteins, is a hard blood clot. Mutations in or absence of Factor IX lead to Hemophilia B.
The buttons below provide an introduction to the structure and function of Factor IX isolated from the venom of a Habu snake.
RESET display to the original wire structure here
1. Kogoy, John. Chime PDF Manual.
2. Mizuno H. et. al. Crystal structure of coagulation factor IX-binding protein from habu snake venom at 2.6 A: implication of central loop swapping based on deletion in the linker region. Journal of Molecular Biology, May 28, 1999, Vol. 289, 103, 112.
3. Rollason, C. Factor IX. April 8, 2003. < http://bssv01.lancs.ac.uk/StuWork/BIOS316/Bios31699/Factor9/FactorIX.htm
4. Wilkinson, Sarah Ann. Coagulation Factor IX. April 8, 2003. < http://bssv01.lancs.ac.uk/StuWork/BIOS316/Bios31699/Coag9/newpage1a.htm >