Human factor VIII is a glycoprotein found in blood plasma that plays a crucial role in blood clotting. Shown here is the C2 domain of the human factor VIII at 1.5 Å resolution. This particular protein is found circulating throughout the body in the blood, which enables it to provide clotting anywhere needed.
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First, lets look at how exactly factor VIII binds. The factor VIII structure consists of 19 ß-strands. (upward running strands are red, downward running strands are orange)
Two out of the three ß-hairpins along with another loop extend outside the main structure and are the primary regions used in membrane binding.