flexibility of the PrP(C) accounts for the fact that TSE's can have
spontaneous origins. As the regular cellular protein varies
between all the possible structures, there is the possiblity that one,
along with certain cellular conditions, could result in the necessary
conformational change from PrP(C) to PrP(Sc).
R, Liu A, Luhrs T, Riek R, von Schroetter C, Garcia F, Billeter M,
Calzolai L, Wider G, Wuthrich K. NMR solution structure of the
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