Gene Networks Database
Strongylocentrotus purpuratus Genes in Development: Transcription Factors
SpZ12-1 is a zinc-finger transcription factor,
which binds the P6 target site in the middle module
of the CyIIIa actin gene.
SpZ12-1 is a negative regulator required for spatial
control of the CyIIIa gene expression (Wang D.G. et.al.,1995).
SpZ12-1 is a protein with twelve tandem Zn fingers of
TFIIIA type near the carboxyl terminus.
This type of Zn finger is one of the most common DNA binding
motifs among eucaryotic transcription factors, and can recognize
a diverse set of DNA sequences. The similarities between the
finger motif of SpZ12-1 and Drosophila segmentation gene kruppel
SpZ12-1 contains many potential sites for phosphorilation,
but the significance of this is hard to evaluate due to the
preponderance of serine, theonine and proline residues in the
sequence. Resent studies have revealed that a number of SpZ12-1
variants are present in the early embryo, they appear to be
the consequence of posttranslational modification (Wang D.G. et.al.,1995).
Egg cytoplasm, embryonic nuclei and cytoplasm (Wang D.G. et.al.,1995).
This factor is present in significant quantities even
in unfertilized egg cytoplasm, and in similar quantities
in mesenchyme blastula-stage embryo cytoplasm.
SpZ12-1 enters the embryonic nuclei between late cleavage
and mesenchyme blastula stages (Wang D.G. et al.,1995).
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