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This page was reviewed in Science, 7 March, 2003.
Vol. 299. pg. 1493.
Movies of Cells
Movies of Cellular Calcium
Movies of Molecular Methods
Movies - by A. Malcolm Campbell
These animations are made with the Macromedia program called Flash, and require
the appropriate browser plug-in. These are standard features for 4.5 or newer
browsers. These animations are being produced beginning in the summer of 1999
and are funded by a Mellon Technology Fellowship through the Associated
Colleges of the South, and Davidson College's Summer Faculty Funding program.
- QT movies of mitosis, meiosis, calcium pumping into SER, calcium regulating
muscles, the yeast two-hybrid system, and PCR developed by A. Malcolm Campbell
at Davidson College. RT-PCR Flash animation was developed by A. Malcolm Campbell
using Macromedia's Flash software.
- Movies of muscle contracting "Muscles Alive" were obtained from
theMedical College of Ohio.
- Movies of Dynein and microtubeles were produced at the ''Biophysics
Group at King's College'' and is maintained by G. Foster.
- Movies of the
White Blood Cells Eating Yeast, Cytotoxic T-cell Killing Its Target, and
T4 phage killing E. coli are ©James A. Sullivan, Quill Graphics.
- Movie of Sea Urchin Fertilization by Mark Terasaki, Department of Physiology,
University of Connecticut Health Center.
Go to Terasaki's home
Simultaneous imaging of an egg at fertilization by phase contrast (left)
and Ca Green fluorescence (right). The fertilizing sperm can be seen at
upper right contacting the egg. There is a Ca action potential around the
entire egg surface (5 th frame), then several seconds later, the Ca wave
starts at the site of sperm entry. The Ca wave triggers cortical granule
exocytosis, leading to the formation of the fertilization envelope. The
fertilization cone (primarily actin filaments) develops later at the sperm
entry point. The first six frames of this sequence are at 0.5 sec intervals,
while the remainder are at 1 sec intervals. movie
The competition of sperm to fertilize and pronuclei fusing were also from
Mark Terasaki. A recent Video Essay was published in Molecular
Biology of the Cell.
- Movie of mouse embryo from gestational day 9.5 through birth by THE
CENTER FOR IN VIVO MICROSCOPY at Duke Univ.
- Movies of calcium waves in retinal glial cells were collected by Eric A.
Newman and Kathleen R. Zahs, Department of Physiology, Univ. Minn. and the
related reference is: Newman, E.A. and Zahs, K.R. (1997) Calcium waves in
retinal glial cells. Science, 275: 844-847. Go
to Eric Newman's home page
Raw Data: Freshly isolated retinae were incubated in the Ca2+
indicator dye Calcium Green-1, labeling astrocytes and Müller cell endfeet
at the vitrealsurface of the retina. Images were acquired with a video-rate
confocal microscope at 0.93 sec intervals.
Enhanced Image: Leading edge of the Ca2+
wave shown in Clip 1. A fluorescence image of the retina is shown in black
and white. The superimposed yellow regions mark the leading edge of the Ca2+
wave (where the change in fluorescence between successive images exceeded
a threshold value). The Ca2+ wave is shown
at normal speed.
- Movie of microtubule treading by Vladimir I. Rodionov and Gary G. Borisy,
University of Wisconsin. Science Vol. 275. pp 215-218. 1997. Go
to Borisy's home page
- Movie of Drosophila gastrulation (EM version) was provided by Dr. Rudi Turner,
Univ. Indiana; Jeff Giacoletti and Thom Kaufman, Univ. Indiana.
- Movie of Drosophila gastrulation (Line Drawing version) was provided by
Jeff Giacoletti and Chris Macri.
More animations and images
can be found on the FlyBase page.
- Movies of fish epidermal cells all taken from "Fish
Epidermal Cell Movies" which is a part of a larger site called "FishScope"
at the Department of Zoology at the University of Washington, Seattle.
- C. elegans microinjection QT Movie generated
by Paul Muhlarad in the lab of Samuel
Ward, Dept. Molecular and Cellular Biology, Univ. Arizona. There are lots
of good pages there if you want more worms.
- C. elegans pronuclei coming together QT movie was produced by the
lab of Dr.
Susan Strome, Indiana University.
The maternal pronucleus migrates from the anterior to the posterior, through
the pseudocleavage furrow. It meets the paternal pronucleus in the posterior
and they migrate anteriorly before fusing and entering mitosis. During these
events, P granules are organized from a dispersed state to the posterior
- Movies of newt and lily mitosis were produced by Shinya Inoue and Rudolf
Oldenbourg at Woods Hole. These were a part of a Video Essay published in
of the Cell.
- Movies of fish epidermal melanophores were produced by Vladimir Rodionov
and Gary Borisy at UW-Madison. These were a part of a Video Essay published
Biology of the Cell.
- The movie of Yeast Mitosis was produced by the lab of Kerry Bloom at UNC-Chapel
Hill. These were a part of a Video Essay published in Molecular
Biology of the Cell.
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