Protein-Protein Interactions

Discovery Question

If you want to find out which proteins interact with your favorite protein, then DIP (Database of Interacting Proteins) is your place. Go to and enter your favorite protein into the "node" field (you can try Sup35 which is the prion-like protein in yeast).

You will get a short table that looks like this:

Notice where the cursor is (bottom left). Click on the code under the DIP Node heading.

In a new browser window, you will get another page that looks like this:

You want to click on the link that says "graph" as shown in the top right corner.

Now you should see a linkage map that illustrates your favorite protein (red node, or dot) connected to many other nodes. Each node is a protein and you can click on each node to find out more about each protein in the network.

Hands-on Page

Genomics Course Page

Biology Department Main Page

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