Pyruvate Carboxylase in Five Organisms




Click here to see cDNA and protein sequence for Apergillus terreus

Click here to see the cDNA and protein sequence for Rattus norvegicus

Click here to see the whole gene and protein sequence for Saccharomyces cerevisiae

Click here to see cDNA and protein sequence for Homo Sapiens

Click here to see the whole gene and protein sequence for Lactococtis lactis
 

         O   O                                                       O                                O
          | |  | |              pyruvate                             | |            H2O             | |
   -O--C--C--CH -------------->  O==C==O  +  -:C--CH3 ----------->  H3C--C + NADH + H+
     (Pyruvate)          carboxylase                                        NAD+            |
                                                                                                            O-
 

    This reaction allows the electron transport chain to function in the mitochondria.  The mechanism converts glucose derivatives (pyruvate) into energy in the bonds of ATP.

    Click here to see the rasmol image of pyruvate carboxylase complexed with pyruvamide: Rasmol

Click here to see the largest the largest open reading frame in pyruvate carboxylase: ORF

Click here to see the molecular weight of pyruvate carboxylase: Molecular Weight

Click here to see the hydropathy plot for pyruvate carboxylase: Kyte Doolittle

Click here to see the most hydrophilic region of this protein: Antigenicity

Click here to see the secondary structure of pyruvate carboxylase: Secondary Structure

Click here to see multiple sequence alignments of this protein in these five organisms: Seq. alignment

Click here to see the percentage of conservation of amino acids in pyruvate carboxlase
between these five organisms: Conservation

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