MAP kinase (Human)

LOCUS      NM_002745            1611 bp                  mRNA            PRI                 09-SEP-1999
    DEFINITION Homo sapiens mitogen-activated protein kinase 1 (MAPK1), mRNA.
    ACCESSION NM_002745
    VERSION NM_002745.1 GI:4506086
    KEYWORDS .
    SOURCE human.
    ORGANISM    Homo sapiens
                             Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
                             Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1611)
    AUTHORS Chan J and Watt VM.
    TITLE eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases
    JOURNAL Oncogene 6 (6), 1057-1061 (1991)
    MEDLINE 91296384
    PUBMED 1648701
REFERENCE 2 (bases 1 to 1611)
    AUTHORS Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
    TITLE Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs
    JOURNAL Biochem. Biophys. Res. Commun. 182 (3), 1416-1422 (1992)
    MEDLINE 92171961
REFERENCE 3 (bases 1 to 1611)
    AUTHORS Gonzalez FA, Raden DL, Rigby MR and Davis RJ.
    TITLE Heterogeneous expression of four MAP kinase isoforms in human tissues
    JOURNAL FEBS Lett. 304 (2-3), 170-178 (1992)
    MEDLINE 92316223
    PUBMED 1319925
REFERENCE 4 (bases 1 to 1611)
    AUTHORS Li L, Wysk M, Gonzalez FA and Davis RJ.
    TITLE Genomic loci of human mitogen-activated protein kinases
    JOURNAL Oncogene 9 (2), 647-649 (1994)
    MEDLINE 94119607
    PUBMED 8290275

COMMENT REFSEQ: This reference sequence was derived from M84489.1.
PROVISIONAL RefSeq: This is a provisional reference sequence record that has not yet been subject to human review.
The final curated reference sequence record may be somewhat different from this one.
FEATURES                Location/Qualifiers
      source             1..1611
                         /organism="Homo sapiens"
                         /db_xref="taxon:9606"
                         /chromosome="22"
                         /map="22q11.2"
                         /cell_line="JURKAT"
                         /cell_type="T CELL"
      gene                1..1611
                         /gene="MAPK1"
                         /note="PRKM1; P41MAPK; P42MAPK; ERK2; MAPK2; PRKM2"
                         /db_xref="LocusID:5594"
                         /db_xref="MIM:176948"
      CDS               328..1410
                         /gene="MAPK1"
                         /EC_number="2.7.1.-"
                         /codon_start=1
                         /db_xref="LocusID:5594"
                         /db_xref="MIM:176948"
                         /product="mitogen-activated protein kinase 1"
                         /protein_id="NP_002736.1"
                         /db_xref="GI:4506087"

/translation="MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYD

NVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVY

IVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT

CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWN

RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDME

LDDLPKEKLKELIFEETARFQPGYRS"

BASE COUNT 403 a 421 c 407 g 380 t

ORIGIN
1 acataatttc tggagccctg taccaacgtg tggccacata ttctgtcagg aaccctgtgt
61 gatcatggtc tggatctgca acacgggcca ggccaaagtc acagatcttg agatcacagg
121 tggtgttgag cagcaggcag gcaggcaatc ggtccgagtg gctgtcggct cttcagctct
181 ccgctcggcg tcttccttcc tctcccggtc agcgtcggcg gctgcaccgg cggcgggcag
241 tcctgcggga ggggcgacaa gagctgaggc gcggccgccg agcgtcgagc tcagcgcggc
301 ggaggcggcg gcggcccggc agccaacatg gcggcggcgg cggcggcggg cgcgggcccg
361 gagatggtcc gcgggcaggt gttcgacgtg gggccgcgct acaccaacct ctcgtacatc
421 ggcgagggcg cctacggcat ggtgtgctct gcttatgata atgtcaacaa agttcgagta
481 gctatcaaga aaatcagccc ctttgagcac cagacctact gccagagaac cctgagggag
541 ataaaaatct tactgcgctt cagacatgag aacatcattg gaatcaatga cattattcga
601 gcaccaacca tcgagcaaat gaaagatgta tatatagtac aggacctcat ggaaacagat
661 ctttacaagc tcttgaagac acaacacctc agcaatgacc atatctgcta ttttctctac
721 cagatcctca gagggttaaa atatatccat tcagctaacg ttctgcaccg tgacctcaag
781 ccttccaacc tgctgctcaa caccacctgt gatctcaaga tctgtgactt tggcctggcc
841 cgtgttgcag atccagacca tgatcacaca gggttcctga cagaatatgt ggccacacgt
901 tggtacaggg ctccagaaat tatgttgaat tccaagggct acaccaagtc cattgatatt
961 tggtctgtag gctgcattct ggcagaaatg ctttccaaca ggcccatctt tccagggaag
1021 cattatcttg accagctgaa tcacattttg ggtattcttg gatccccatc acaagaagac
1081 ctgaattgta taataaattt aaaagctagg aactatttgc tttctcttcc acacaaaaat
1141 aaggtgccat ggaacaggct gttcccaaat gctgactcca aagctctgga cttattggac
1201 aaaatgttga cattcaaccc acacaagagg attgaagtag aacaggctct ggcccaccca
1261 tatctggagc agtattacga cccgagtgac gagcccatcg ccgaagcacc attcaagttc
1321 gacatggaat tggatgactt gcctaaggaa aagctaaaag aactaatttt tgaagagact
1381 gctagattcc agccaggata cagatcttaa atttgtcagg acaagggctc agaggactgg
1441 acgtgctcag acatcggtgt tcttcttccc agttcttgac ccctggtcct gtctccagcc
1501 cgtcttggct tatccacttt gactcctttg agccgtttgg aggggcggtt tctggtagtt
1561 gtggctttta tgctttcaaa gaatttcttc agtccagaga attcactggc c //