LOCUS       NM_002654    2287 bp    mRNA            PRI       19-MAR-1999
DEFINITION  Homo sapiens pyruvate kinase, muscle (PKM2) mRNA.
ACCESSION   NM_002654
VERSION     NM_002654.1  GI:4505838
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
            Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Tani,K., Yoshida,M.C., Satoh,H., Mitamura,K., Noguchi,T.,
            Tanaka,T., Fujii,H. and Miwa,S.
  TITLE     Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment
            and expression in hepatoma
  JOURNAL   Gene 73, 509-516 (1988)
  MEDLINE   89211988
COMMENT     REFSEQ: This reference sequence was derived from M23725.
            Draft entry and computer-readable sequence for [1] kindly provided
            by K.Tani, 04-APR-1989.
            PROVISIONAL RefSeq: This is a provisional reference sequence record
            that has not yet been subject to human review. The final curated
            reference sequence record may be somewhat different from this one.
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /tissue_type="liver"
     gene            1..2287
                     /gene="PKM2"
                     /note="PK3"
                     /db_xref="LocusID:5315"
                     /db_xref="MIM:179050"
     CDS             110..1705
                     /gene="PKM2"
                     /EC_number="2.7.1.40"
                     /codon_start=1
                     /db_xref="LocusID:5315"
                     /db_xref="MIM:179050"
                     /product="pyruvate kinase, muscle"
                     /protein_id="NP_002645.1"
                     /db_xref="GI:4505839"
                     /translation="MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARN
                     TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDP
                     ILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLD
                     YKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDL
                     PAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG
                     VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESM
                     IKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAREAEAAIYHL
                     QLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
                     IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDV
                     VIVLTGWRPGSGFTNTMRVVPVP"
BASE COUNT      501 a    648 c    654 g    484 t
ORIGIN      
        1 ggctgaggca gtggctcctt gcacagcagc tgcacgcgcc gtggctccgg atcttcttcg
       61 tctttgcagc gtagcccgag tcggtcagcg ccagaggacc tcagcagcca tgtcgaagcc
      121 ccatagtgaa gccgggactg ccttcattca gacccagcag ctgcacgcag ccatggctga
      181 cacattcctg gagcacatgt gccgcctgga cattgattca ccacccatca cagcccggaa
      241 cactggcatc atctgtacca ttggcccagc ttcccgatca gtggagacgt tgaaggagat
      301 gattaagtct ggaatgaatg tggctcgtct gaacttctct catggaactc atgagtacca
      361 tgcggagacc atcaagaatg tgcgcacagc cacggaaagc tttgcttctg accccatcct
      421 ctaccggccc gttgctgtgg ctctagacac taaaggacct gagatccgaa ctgggctcat
      481 caagggcagc ggcactgcag aggtggagct gaagaaggga gccactctca aaatcacgct
      541 ggataacgcc tacatggaaa agtgtgacga gaacatcctg tggctggact acaagaacat
      601 ctgcaaggtg gtggaagtgg gcagcaagat ctacgtggat gatgggctta tttctctcca
      661 ggtgaagcag aaaggtgccg acttcctggt gacggaggtg gaaaatggtg gctccttggg
      721 cagcaagaag ggtgtgaacc ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa
      781 ggacatccag gatctgaagt ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt
      841 catccgcaag gcatctgatg tccatgaagt taggaaggtc ctgggagaga agggaaagaa
      901 catcaagatt atcagcaaaa tcgagaatca tgagggggtt cggaggtttg atgaaatcct
      961 ggaggccagt gatgggatca tggtggctcg tggtgatcta ggcattgaga ttcctgcaga
     1021 gaaggtcttc cttgctcaga agatgatgat tggacggtgc aaccgagctg ggaagcctgt
     1081 catctgtgct actcagatgc tggagagcat gatcaagaag ccccgcccca ctcgggctga
     1141 aggcagtgat gtggccaatg cagtcctgga tggagccgac tgcatcatgc tgtctggaga
     1201 aacagccaaa ggggactatc ctctggaggc tgtgcgcatg cagaacctga ttgcccgtga
     1261 ggcagaggct gccatctacc acttgcaatt atttgaggaa ctccgccgcc tggcgcccat
     1321 taccagcgac cccacagaag ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg
     1381 cagtggggcc ataatcgtcc tcaccaagtc tggcaggtct gctcaccagg tggccagata
     1441 ccgcccacgt gcccccatca ttgctgtgac ccggaatccc cagacagctc gtcaggccca
     1501 cctgtaccgt ggcatcttcc ctgtgctgtg caaggaccca gtccaggagg cctgggctga
     1561 ggacgtggac ctccgggtga actttgccat gaatgttggc aaggcccgag gcttcttcaa
     1621 gaagggagat gtggtcattg tgctgaccgg atggcgccct ggctccggct tcaccaacac
     1681 catgcgtgtt gttcctgtgc cgtgatggac cccagagccc ctcctccagc ccctgtccca
     1741 cccccttccc ccagcccatc cattaggcca gcaacgcttg tagaactcac tctgggctgt
     1801 aacgtggcac tggtaggttg ggacaccagg gaagaagatc aacgcctcac tgaaacatgg
     1861 ctgtgtttgc agcctgctct agtgggacag cccagagcct ggctgcccca tcatgtggcc
     1921 ccacccaatc aagggaagaa ggaggaatgc tggactggag gcccctggag ccagatggca
     1981 agagggtgac agcttccttt cctgtgtgta ctctgtccag ttcctttaga aaaaatggat
     2041 gcccagagga ctcccaaccc tggcttgggg tcaagaaaca gccagcaaga gttaggggcc
     2101 ttagggcact gggctgttgt tccattgaag ccgactctgg ccctggccct tacttgcttc
     2161 tctagctctc taggcctctc cagtttgcac ctgtccccac cctccactca gctgtcctgc
     2221 agcaaacact ccaccctcca ccttccattt tcccccacta ctgcagcacc tccaggcctg
     2281 ttgccgc
//