GENBANK SEARCH RESULTS FOR
Also known as AANAT, arylalkylamine-N-acetyltransferase is a catalyst
that "plays a major role in the regulation of the melatonin circadian rhythm
in vertebrates" (Ferry, et al., abstract). The reaction which AANAT
catalyzes is that which occurs between acetyl-CoA and serotonin resulting
in N-acetylserotonin (Ferry, et al., abstract).
N-acetylserotonin is the precurser to melatonin.
For a realated review click here.
The actual structure of this enzyme can be seen in the Rasmol
image of sheep (Ovis aries)Serotonin N-Acetyltransferase
Id: 12412 PDB Id: 1B6B ).
For more information on this image click here.
Unfourtunatly, Genbank only provides sequence information for three
of the five genome organims (Homo sapiens, Drosophila melanogaster,
Mus musculus , C. elegans, and S. cervisiae). The Genbank results
for the amino acid and cDNA sequences of these three organisms plus
eight others are available through the links below.
For a list of AANAT and serotonin related abstracts click
For MacDNAsis results click here. (For only the largest ORF for the Human cDNA, click here.)
Ferry, G, et al. 2000. Substrate Specificity and Inhibition Studies
of Human Serotonin N-Acetyltransferace. JBC Online.
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