LOCUS HUMCYCLOX 3387 bp mRNA PRI 31-DEC-1994
DEFINITION Homo sapiens cyclooxygenase-2 (Cox-2) mRNA, complete cds.
ACCESSION M90100
VERSION M90100.1 GI:181253
KEYWORDS cyclooxygenase-2; prostaglandin synthase.
SOURCE Homo sapiens umbilical vein cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3387)
AUTHORS Hla,T. and Neilson,K.
TITLE Human cyclooxygenase-2 cDNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7384-7388 (1992)
MEDLINE 92366465
FEATURES Location/Qualifiers
source 1..3387
/organism="Homo sapiens"
/db_xref="taxon:9606"
/cell_type="endothelial"
/tissue_type="umbilical vein"
5'UTR 1..97
/gene="Cox-2"
gene 1..3387
/gene="Cox-2"
CDS 98..1912
/gene="Cox-2"
/EC_number="1.14.99.1"
/codon_start=1
/product="cyclooxygenase-2"
/protein_id="AAA58433.1"
/db_xref="GI:181254"
/translation="MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDC
TRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYV
LTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDS
NEIVGKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNH
IYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE
VFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDY
VQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQ
FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFN
EYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETM
VEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSF
SVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL"
sig_peptide 98..148
/gene="Cox-2"
mat_peptide 149..1909
/gene="Cox-2"
/EC_number="1.14.99.1"
/product="cyclooxygenase-2"
3'UTR 1913..3387
/gene="Cox-2"
polyA_signal 3369..3374
/gene="Cox-2"
BASE COUNT 1010 a 712 c 633 g 1032 t
ORIGIN
1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca
61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct
121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa
181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg
241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa
301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt
361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca
421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt
481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc
541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct
601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc
661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa
721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg
781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta
841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca
901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc
961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga
1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa
1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga
1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa
1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata
1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt
1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc
1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc
1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac
1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga
1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat
1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc
1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc
1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt
1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact
1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa
1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt
1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg
2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc
2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga
2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac
2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat
2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta
2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga
2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt
2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa
2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt
2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata
2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg
2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat
2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc
2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt
2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat
2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat
3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc
3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg
3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct
3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta
3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct
3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc
3361 ttaagaagat taaaaaaaaa aaaaaag
//