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        Ras proteins are monomeric GTPases responsible for transmitting cell proliferation or differentiation messages relayed from receptor tyrosine kinases.  Ras  activity may be controlled by either GTPase-activating proteins (GAPs) or guanine nucleotide releasing proteins (GNRPs) but due to Ras's moderate ability to hydrolse GTP and the relatively  high intracellular concentration of GTP vs. GDP, GNRPs serve as the principle regulators of this G protein's activity.  Ras proteins are particuarly notable in their strong association with many forms of cancer.  It has been estimated that at least 30% of all forms of human cancer are responsible, at least in part, by an oncogenic form of Ras.1

A RasMol representation of the Ras homolog from E. coli, Era, may be found here: Image

                          Organism          Nucleotide Sequence?   Protein Sequence?

S. cerevisiae                    Yes                   
Homo sapiens Yes Yes
 Escherichia coli  Yes Yes
Mus musculus Yes Yes, mRNA
Drosophila melanogaster Yes Yes
Caenorhabditis elegans Yes Yes


1  Alberts, Bruce, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, James D. Watson.  Molecular Biology of the Cell.  Garland Publishing, Inc.  1994.  pp. 763-764.

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