Genbank Search Results

Phospholipase C
Click on picture for a clearer image of phospholipase C

Phospholipase C is a membrane associated enzyme often used to study lipid-protein interactions.  When stimulated by various hormones, phospholipase C hydrolyzes polyphosphoinositides to give second messengers such as diacyglycerol and inositol 1,4,5-triphosphate.  All isoforms of phospholipase C require the binding of a specific lipid to be able to function, regulating cellular responses.

Before viewing the nucleotide and amino acid sequences of phospholipase C from 5 eukaryotes, it would be helpful to view the structure of the molecule.  After all, the function of a molecule is often indicated by its structure.  To view a RasMol image of phospholipase C, click here.

Organism Nucleotide Sequence Amino Acid Sequence
Homo sapiens complete cDNA YES
Bos taurus complete cDNA YES
Drosophila melanogaster complete cDNA YES
Saccharomyces cerevisae complete cDNA YES
Rattus norvegicus complete cDNA YES