Phospholipase C is a membrane associated enzyme often used to study lipid-protein interactions. When stimulated by various hormones, phospholipase C hydrolyzes polyphosphoinositides to give second messengers such as diacyglycerol and inositol 1,4,5-triphosphate. All isoforms of phospholipase C require the binding of a specific lipid to be able to function, regulating cellular responses.
Before viewing the nucleotide and amino acid sequences of phospholipase C from 5 eukaryotes, it would be helpful to view the structure of the molecule. After all, the function of a molecule is often indicated by its structure. To view a RasMol image of phospholipase C, click here.
|Organism||Nucleotide Sequence||Amino Acid Sequence|
|Homo sapiens||complete cDNA||YES|
|Bos taurus||complete cDNA||YES|
|Drosophila melanogaster||complete cDNA||YES|
|Saccharomyces cerevisae||complete cDNA||YES|
|Rattus norvegicus||complete cDNA||YES|