DEFINITION D.melanogaster alcohol dehydrogenase gene, complete cds.
ACCESSION J01066 M11290
NID g156787
KEYWORDS alcohol dehydrogenase.
SOURCE D.melanogaster, cDNA to mRNA, and DNA (see comment).
ORGANISM Drosophila melanogaster
Eukaryotae; mitochondrial eukaryotes; Metazoa; Arthropoda;
Tracheata; Insecta; Pterygota; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila.
REFERENCE 1 (bases 1683 to 2126; 1528 to 1612)
AUTHORS Benyajati,C., Wang,N., Reddy,A., Weinberg,E. and Sofer,W.
TITLE Alcohol dehydrogenase in Drosophila: Isolation and characterization
of messenger RNA and cDNA clone
JOURNAL Nucleic Acids Res. 8, 5649-5667 (1980)
MEDLINE 81124290
REFERENCE 2 (bases 1433 to 1577)
AUTHORS Goldberg,D.A.
TITLE Isolation and partial characterization of the Drosophila alcohol
dehydrogenase gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 77, 5794-5798 (1980)
MEDLINE 81077261
REFERENCE 3 (bases 1044 to 1158; 1192 to 1949)
AUTHORS Benyajati,C., Place,A.R., Powers,D.A. and Sofer,W.
TITLE Alcohol dehydrogenase gene of Drosophila melanogaster: Relationship
of intervening sequences to functional domains in the protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 2717-2721 (1981)
MEDLINE 81247357
REFERENCE 4 (bases 1137 to 1213)
AUTHORS Benyajati,C., Place,A.R., Wang,N., Pentz,E. and Sofer,W.
TITLE Deletions at intervening sequence splice sites in the alcohol
dehydrogenase gene of Drosophila
JOURNAL Nucleic Acids Res. 10, 7261-7272 (1982)
MEDLINE 83116953
REFERENCE 5 (bases 1 to 1100)
AUTHORS Benyajati,C., Spoerel,N., Haymerle,H. and Ashburner,M.
TITLE The messenger RNA for alcohol dehydrogenase in Drosophila
melanogaster differs in its 5' end in different developmental
stages
JOURNAL Cell 33, 125-133 (1983)
MEDLINE 84282660
REFERENCE 6 (bases 1122 to 1216; 1291 to 1321; 1890 to 1949)
AUTHORS Benyajati,C., Place,A.R. and Sofer,W.
TITLE Formaldehyde mutagenesis in Drosophila: Molecular analysis of
Adh-negative mutants
JOURNAL Mutat. Res. 111, 1-7 (1983)
MEDLINE 84013866
FEATURES Location/Qualifiers
source 1..2126
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
gene 1..2126
/note="Alcohol dehydrogenase"
/gene="Adh"
/allele=""
/db_xref="FlyBase:FBgn0000055;"
prim_transcript 267..2126
/gene="Adh"
/note="Adh adult mRNA [1],[5]"
intron 354..1007
/gene="Adh"
/note="Adh adult 5' intron"
/db_xref="FlyBase:FBgn0000055;"
prim_transcript 974..2126
/gene="Adh"
/note="Adh larval mRNA [5]"
CDS join(1044..1142,1208..1612,1683..1949)
/gene="Adh"
/note="alcohol dehydrogenase"
/codon_start=1
/db_xref="FlyBase:FBgn0000055;"
/db_xref="PID:g156788"
/translation="MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIE
NPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLIN
GAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVT
GFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLV
HKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKL
DLGTLEAIQWTKHWDSGI"
BASE COUNT 623 a 526 c 448 g 529 t
ORIGIN HinfI site [Cell 33, 125-133 (1983)].
1 gactcttttt tgattttgga atattttcgt tcgttttatg tttttacgtt ttcgcatatt
61 tgtttcacag tgcactttct ggtgttccat tttctattgg gctcttaacc ccgcatttgt
121 ttgcagatca cttgcttgcg catttttatt gcattttaca tattacacat tatttgaacg
181 ccgctgctgc tgcatccgtc gacgtcgact gcactcgccc ccacgagaga acagtattta
241 aggagctgcg aaggtccaag tcaccgatta ttgtctcagt gcagttgtca gttgcagttc
301 agcagacggg ctaacgagta cttgcatctc ttcaaattta cttaattgat caagtaagta
361 gcaaaagggc acccaattaa aggaaattct tgtttaattg aatttattat gcaagtgcgg
421 aaataaaatg acagtattaa ttagtaaata ttttgtaaaa tcatatataa tcaaatttat
481 tcaatcagaa ctaattcaag ctgtcacaag tagtgcgaac tcaattaatt ggcatcgaat
541 taaaatttgg aggcctgtgc cgcatattcg tcttggaaaa tcacctgtta gttaacttct
601 aaaaatagga attttaacat aactcgtccc tgttaatcgg cgccgtgcct tcgttagcta
661 tctcaaaagc gagcgcgtgc agacgagcag taattttcca agcatcaggc atagttgggc
721 ataaattata aacatacaaa ccgaatacta atatagaaaa agctttgccg gtacaaaatc
781 ccaaacaaaa acaaaccgtg tgtgccgaaa aataaaaata aaccataaac taggcagcgc
841 tgccgtcgcc ggctgagcag cctgcgtaca tagccgagat cgcgtaacgg tagataatga
901 aaagctctac gtaaccgaag cttctgctgt acggatcttc ctataaatac ggggccgaca
961 cgaactggaa accaacaact aacggagccc tcttccaatt gaaacagatc gaaagagcct
1021 gctaaagcaa aaaagaagtc accatgtcgt ttactttgac caacaagaac gtgattttcg
1081 ttgccggtct gggaggcatt ggtctggaca ccagcaagga gctgctcaag cgcgatctga
1141 aggtaactat gcgatgccca caggctccat gcagcgatgg aggttaatct cgtgtattca
1201 atcctagaac ctggtgatcc tcgaccgcat tgagaacccg gctgccattg ccgagctgaa
1261 ggcaatcaat ccaaaggtga ccgtcacctt ctacccctat gatgtgaccg tgcccattgc
1321 cgagaccacc aagctgctga agaccatctt cgcccagctg aagaccgtcg atgtcctgat
1381 caacggagct ggtatcctgg acgatcacca gatcgagcgc accattgccg tcaactacac
1441 tggcctggtc aacaccacga cggccattct ggacttctgg gacaagcgca agggcggtcc
1501 cggtggtatc atctgcaaca ttggatccgt cactggattc aatgccatct accaggtgcc
1561 cgtctactcc ggcaccaagg ccgccgtggt caacttcacc agctccctgg cggtaagttg
1621 atcaaaggaa acgcaaagtt ttcaagaaaa aacaaaacta atttgattta taacaccttt
1681 agaaactggc ccccattacc ggcgtgaccg cttacaccgt gaaccccggc atcacccgca
1741 ccaccctggt gcacaagttc aactcctggt tggatgttga gccccaggtt gctgagaagc
1801 tcctggctca tcccacccag ccatcgttgg cctgcgccga gaacttcgtc aaggctatcg
1861 aactgaacca gaacggagcc atctggaaac tggacctggg caccctggag gccatccagt
1921 ggaccaagca ctgggactcc ggcatctaag aagtgatact cccaaaaaaa aaaaaaaaca
1981 taacattagt tcatagggtt ctgcgaacca gaagatattc acgcaaggca ataaggctga
2041 ttcgatgcac actcacattc ttctcctaat acgataataa aactttccat gaaaaatatg
2101 gaaaatatat gaaaattgag aaatcc