DEFINITION Human mRNA for liver alcohol dehydrogenase (EC 1.1.1.1) gamma 2

subunit from ADH3 locus.

ACCESSION X04299

NID g28403

KEYWORDS alcohol dehydrogenase; dehydrogenase.

SOURCE human.

ORGANISM Homo sapiens

Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;

Primates; Catarrhini; Hominidae; Homo.

REFERENCE 1 (bases 1 to 1457)

AUTHORS Hoog,J.O., Heden,L.O., Larsson,K., Jornvall,H. and von

Bahr-Lindstrom,H.

TITLE The gamma 1 and gamma 2 subunits of human liver alcohol

dehydrogenase. cDNA structures, two amino acid replacements, and

compatibility with changes in the enzymatic properties

JOURNAL Eur. J. Biochem. 159 (2), 215-218 (1986)

MEDLINE 87004628

COMMENT See x04350 for gamma 1 subunit

Data kindly reviewed (20-OCT-1986) by J-O. Hoog.

FEATURES Location/Qualifiers

source 1..1457

/organism="Homo sapiens"

/db_xref="taxon:9606"

CDS 73..1200

/note="gamma 2 subunit (aa 1-375)"

/codon_start=1

/db_xref="PID:g28404"

/db_xref="SWISS-PROT:P00326"

/translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAA GICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQC
GKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQY
TVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLG
GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEV
LKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPM
LLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVLPFEKINEGF
DLLRSGKSIRTVLTF"

misc_feature 1309..1314

/note="pot. polyA signal"

misc_feature 1397..1403

/note="pot. polyA signal"

misc_feature 1434..1439

/note="pot. polyA signal"

polyA_site 1457

/note="polyA site"

BASE COUNT 419 a 313 c 356 g 369 t

ORIGIN

1 gatgcactca agcagagaag aaatccacaa gtactcacca gcctcctggt ctgcagagaa

61 gacagaatca atatgagcac agcaggaaaa gtaatcaaat gcaaagcagc tgtgctatgg

121 gagttaaaga aacccttttc cattgaggag gtagaggttg cacctcctaa ggctcatgaa

181 gttcgcatta agatggtggc tgcaggaatc tgtcgttcag atgagcatgt ggttagtggc

241 aacctggtga ccccccttcc tgtgatttta ggccatgagg cagccggcat cgtggaaagt

301 gttggagaag gggtgactac agtcaaacca ggtgataaag tcatcccgct ctttactcct

361 cagtgtggaa aatgcagaat ttgcaaaaac ccagaaagca actactgctt gaaaaatgat

421 ctaggcaatc ctcgggggac cctgcaggat ggcaccagga ggttcacctg cagcgggaag

481 cccatccacc acttcgtcgg cgtcagcacc ttctcccagt acacagtggt ggatgagaat

541 gcagtagcca aaattgatgc agcctcgccc ctggagaaag tctgcctcat tggctgtgga

601 ttttcgactg gttatgggtc tgcagtcaaa gttgccaagg tcaccccagg gtctacctgt

661 gctgtgtttg gcctgggagg ggtcggccta tctgttgtta tgggctgtaa agcagctgga

721 gcagccagaa tcattgctgt ggacatcaac aaggacaaat ttgcaaaggc taaagagttg

781 ggtgccactg aatgcatcaa ccctcaagac tacaagaaac ccattcagga agtgctaaag

841 gaaatgactg atggaggtgt ggatttttcg tttgaagtca tcggtcagct tgacaccatg

901 atggcttccc tgttatgttg tcatgaggca tgtggcacaa gtgtcattgt aggggtacct

961 cctgattccc agaacctctc aataaaccct atgctgctac tgactggacg cacgtggaaa

1021 ggagctattt ttggaggctt taagagtaaa gaatctgtcc ccaaacttgt ggctgacttt

1081 atggctaaga agttttcact ggatgcatta ataacaaatg ttttaccttt tgaaaaaata

1141 aatgaaggat ttgacctgct tcgctctgga aagagtatcc gtaccgtcct gacgttttga

1201 aacaatacag atgccttccc ttgtagcagt tttcagcctc ctctacccta catgatctgg

1261 agcaacagct aggaaatatc attaattctg ctcttcagag atgttaaaaa taaattacac

1321 gtgggagctt tccaaagaaa tggaaattga tgggaaatta tttgtcaagc aaatgtttaa

1381 aatccaaatg agaactaaat aaagtgttga acatcaactg gggaattgaa gccaataaac

1441 cttccttctt aaccatt