SOURCE      human
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.

LOCUS       2873350       916 aa                              04-MAY-1998
DEFINITION  hexokinase I.
ACCESSION   2873350
PID         g2873350
DBSOURCE    GENBANK: locus SEG_HSHEXKIN01, accession AF016349
            GENBANK: locus SEG_HSHEXKIN03, accession AF016351
            GENBANK: locus SEG_HSHEXKIN04, accession AF016352
            GENBANK: locus SEG_HSHEXKIN05, accession AF016353
            GENBANK: locus SEG_HSHEXKIN06, accession AF016354
            GENBANK: locus SEG_HSHEXKIN07, accession AF016355
            GENBANK: locus SEG_HSHEXKIN08, accession AF016356
            GENBANK: locus SEG_HSHEXKIN09, accession AF016357
            GENBANK: locus SEG_HSHEXKIN10, accession AF016358
            GENBANK: locus SEG_HSHEXKIN11, accession AF016359
            GENBANK: locus SEG_HSHEXKIN12, accession AF016360
            GENBANK: locus SEG_HSHEXKIN13, accession AF016361
            GENBANK: locus SEG_HSHEXKIN14, accession AF016362
            GENBANK: locus SEG_HSHEXKIN15, accession AF016363
            GENBANK: locus SEG_HSHEXKIN16, accession AF016364
            GENBANK: locus SEG_HSHEXKIN17, accession AF016365
KEYWORDS

REFERENCE   1  (residues 1 to 916)
  AUTHORS   Ruzzo,A., Andreoni,F. and Magnani,M.
  TITLE     Structure of the human hexokinase type I gene and nucleotide
            sequence of the 5'-flanking region
  JOURNAL   Biochem. J. 331, 607-613 (1998)
REFERENCE   2  (residues 1 to 916)
  AUTHORS   Ruzzo,A., Andreoni,F. and Magnani,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-1997) Institute of Biochemistry 'G. Fornaini',
            University of Urbino, Via Saffi 2, Urbino, Pesaro-Urbino 61029,
            Italy
REFERENCE   3  (residues 1 to 916)
  AUTHORS   Ruzzo,A., Andreoni,F. and Magnani,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-FEB-1998) Institute of Biochemistry 'G. Fornaini',
            University of Urbino, Via Saffi 2, Urbino, Pesaro-Urbino 61029,
            Italy
  REMARK    Sequence update by submitter
COMMENT     Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /clone="YAC 908_E_9"
                     /chromosome="10"
     Protein         1..916
                     /product="hexokinase I"
                     /EC_number="2.7.7.1"
     CDS             1..916
                     /gene="HK1"
                     /note="alternatively spliced form expressed in red blood
                     cells"
                     /coded_by="join(AF016349:120..179,AF016351:207..369,
                     AF016352:54..202,AF016353:68..187,AF016354:198..293,
                     AF016355:162..261,AF016355:366..549,AF016356:90..245,
                     AF016357:104..337,AF016358:152..456,AF016359:198..346,
                     AF016359:661..780,AF016360:72..167,AF016361:201..300,
                     AF016362:74..257,AF016363:182..337,AF016364:166..399,
                     AF016365:176..320)"
ORIGIN
        1 mdcehslslp crgaeaweig idkylyamrl sdetlidimt rfrkemkngl srdfnptatv
       61 kmlptfvrsi pdgsekgdfi aldlggssfr ilrvqvnhek nqnvhmesev ydtpenivhg
      121 sgsqlfdhva eclgdfmekr kikdkklpvg ftfsfpcqqs kideailitw tkrfkasgve
      181 gadvvkllnk aikkrgdyda nivavvndtv gtmmtcgydd qhcevgliig tgtnacymee
      241 lrhidlvegd egrmcintew gafgddgsle dirtefdrei drgslnpgkq lfekmvsgmy
      301 lgelvrlilv kmakegllfe gritpelltr gkfntsdvsa ieknkeglhn akeiltrlgv
      361 epsdddcvsv qhvctivsfr sanlvaatlg ailnrlrdnk gtprlrttvg vdgslykthp
      421 qysrrfhktl rrlvpdsdvr fllsesgsgk gaamvtavay rlaeqhrqie etlahfhltk
      481 dmllevkkrm raemelglrk qthnnavvkm lpsfvrrtpd gtengdflal dlggtnfrvl
      541 lvkirsgkkr tvemhnkiya ipieimqgtg eelfdhivsc isdfldymgi kgprmplgft
      601 fsfpcqqtsl dagilitwtk gfkatdcvgh dvvtllrdai krreefdldv vavvndtvgt
      661 mmtcayeept cevglivgtg snacymeemk nvemvegdqg qmcinmewga fgdngclddi
      721 rthydrlvde yslnagkqry ekmisgmylg eivrnilidf tkkgflfrgq isetlktrgi
      781 fetkflsqie sdrlallqvr ailqqlglns tcddsilvkt vcgvvsrraa qlcgagmaav
      841 vdkirenrgl drlnvtvgvd gtlyklhphf srimhqtvke lspkcnvsfl lsedgsgkga
      901 alitavgvrl rteass


LOCUS       HSHKRI1      1061 bp    DNA             PRI       03-FEB-1998
DEFINITION  Homo sapiens hexokinase (HK) gene, isozyme R, partial cds.
ACCESSION   AF029306
NID         g2827144
KEYWORDS    .
SEGMENT     1 of 2
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Murakami,K. and Piomelli,S.
  TITLE     The erythrocyte-specific hexokinase isozyme (HKR) and the common
            hexokinase isozyme (HKI) are produced from a single gene by
            alternate promoters
  JOURNAL   Blood 90 (10), 272a (1998)
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Murakami,K. and Piomelli,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-1997) Pediatrics, Columbia University, 630 West
            168th Street, New York, NY 10032, USA
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22"
     mRNA            697..>876
                     /gene="HK"
                     /note="isozyme R"
                     /product="hexokinase"
     CDS             817..>876
                     /gene="HK"
                     /note="isozyme R"
                     /codon_start=1
                     /product="hexokinase"
                     /db_xref="PID:g2827147"
                     /translation="MDCEHSLSLPCRGAEAWEIG"
BASE COUNT      277 a    213 c    347 g    224 t

ORIGIN  
        1 cccttctaac ctcaccaggc tgttatcagg agaaatgaag caataaatga gaaattgctg
       61 tgcaaactgt caacgttatg taaacattgc tattcagagt gtgctcccag gtgcgggagg
      121 tacagctgtt atctgttgga gatcactcct gaagtaacat tcctagtgcc atgggtcaga
      181 tgggaattgg tacagacatt ccaacttaga aggcagcctt tattgtctta taagcaggtg
      241 cgtttcctgg ggtggcagcc tggcactggt cactccaacc ccaacttgtg taggaggtac
      301 cacagtaaat gagtagagag agttcagggg acttgaaggg aagtggaggg ccatctggag
      361 agggagggaa ctaaggactc cctgtgggtt gggtcttcct gaggatccag ggagtaactg
      421 tcaaggagcc ttagcaggga tctaagagct atgcaagagc aaaaagaggc aaattattaa
      481 ggaaattagt gaagtcagca ctggaacaac agagagggga cacagcagtg cagcatgggc
      541 cctggcctca ggaagctgtc tgattggggc agataggacc agccccctag aagacagtca
      601 cccatatcag ttaggcagtc atgactcagt gttacttatc tgaggcccag gttgcatgag
      661 gggttggggg tgggatggac agagcactgg ctgggcatca ggactaggct ggagtcctgg
      721 ctcaaaactc taccacaacc tgacactggg caagatggcc cacctgtggc atcccaggtt
      781 cctgccctgt aaagaggagt ctgggtgtat atccagatgg actgtgagca cagcctgagt
      841 ttgccctgtc gaggtgctga ggcctgggag attggggtga gtagctgtgg tccagggaag
      901 gttggcaagc tgggccttag atgagagggg atgcttggtc acgcagaggt gagtggagaa
      961 cgcagggcaa ggaacggaat atgagcggcg aacaaatgga gtggacatgg tgggggcaca
     1021 agatggtggg aagtggcctt gttgcggcca cagtggaaga a

LOCUS       HSHKRI2       515 bp    DNA             PRI       03-FEB-1998
DEFINITION  Homo sapiens hexokinase (HK) gene, isozyme I, partial cds.
ACCESSION   AF029305
NID         g2827145
KEYWORDS    .
SEGMENT     2 of 2
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Murakami,K. and Piomelli,S.
  TITLE     The erythrocyte-specific hexokinase isozyme (HKR) and the common
            hexokinase isozyme (HKI) are produced from a single gene by
            alternate promoters
  JOURNAL   Blood 90 (10), 272a (1998)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Murakami,K. and Piomelli,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-1997) Pediatrics, Columbia University, 630 West
            168th Street, New York, NY 10032, USA
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22"
     gene            order(AF029306:1..1061,1..>515)
                     /gene="HK"
     mRNA            248..>391
                     /gene="HK"
                     /note="isozyme I"
                     /product="hexokinase"
     CDS             329..>391
                     /gene="HK"
                     /note="isozyme I"
                     /codon_start=1
                     /product="hexokinase"
                     /db_xref="PID:g2827148"
                     /translation="MIAAQLLAYYFTELKDDQVKK"
BASE COUNT       68 a    197 c    193 g     57 t

ORIGIN
        1 tgcgtcgccg ccccctttcc ggcgcaggag ggagcggccg ccgcgtcccc gctccccggc
       61 cgggacgcca ccgccgggcg ttgcagaggc gcgccgcaac caatgggcgt ggaggaggtg
      121 ggtcggctgg cggctgtcac cctccagggg acgggagcgc ggagaccggg agcgcgcgag
      181 ctgtcgccgc gccccgggcc gagggggagg agccggggga ggaggaggag gaggagccgc
      241 cgagcagccg ccggaggacc acggctcgcc agggctgcgg aggaccgacc gtccccacgc
      301 ctgccgcccc gcgaccccga ccgccagcat gatcgccgcg cagctcctgg cctattactt
      361 cacggagctg aaggatgacc aggtcaaaaa ggtgagcccc cgcccgcgcc gccgctggtc
      421 ctggccgcag ccttgcgttc cggcatccgc tcgccgcctc cgctgcgtcc atcctccggc
      481 gcccggcctt ctccgggcca gcatcgagtt ggact