LOCUS HUMHEXKIN
3580 bp mRNA
PRI 08-NOV-1994
DEFINITION Human hexokinase 1 (HK1) mRNA, complete cds.
ACCESSION M75126 X61091
NID g184020
KEYWORDS hexokinase 1.
SOURCE Homo sapiens adult kidney cDNA
to mRNA.
ORGANISM Homo sapiens
Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3580)
AUTHORS Nishi,S., Seino,S. and Bell,G.I.
TITLE Human hexokinase: sequences of
amino- and carboxyl-terminal halves
are homologous
JOURNAL Biochem. Biophys. Res. Commun. 157 (3),
937-943 (1988)
MEDLINE 89087485
FEATURES
Location/Qualifiers
source
1..3580
/organism="Homo sapiens"
/db_xref="taxon:9606"
/dev_stage="adult"
/tissue_type="kidney"
5'UTR
1..81
gene
82..2835
/gene="HK1"
CDS
82..2835
/gene="HK1"
/codon_start=1
/db_xref="GDB:G00-120-044"
/product="hexokinase 1"
/db_xref="PID:g184021"
/translation="MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFR
KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKN
QNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQ
SKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG
YDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTE
FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKF
NTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGA
ILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSG
KGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAV
VKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEI
MQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFK
ATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGS
NACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVNEYSLNAGKQR
YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKTRGIFETKFLSQIESDRLALL
QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNV
TVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTE
ASS"
3'UTR
2836..3580
BASE COUNT 867 a 905
c 1030 g 778 t
ORIGIN chromosome 10q.
1 ccgccggagg accacggctc
gccagggctg cggaggaccg accgtcccca cgcctgccgc
61 cccgcgaccc cgaccgccag catgatcgcc
gcgcagctcc tggcctatta cttcacggag
121 ctgaaggatg accaggtcaa aaagattgac
aagtatctgt atgccatgcg gctctccgat
181 gaaactctca tagatatcat gactcgcttc
aggaaggaga tgaagaatgg cctctcccgg
241 gattttaatc caacagccac agtcaagatg
ttgccaacat tcgtaaggtc cattcctgat
301 ggctctgaaa agggagattt cattgccctg
gatcttggtg ggtcttcctt tcgaattctg
361 cgggtgcaag tgaatcatga gaaaaaccag
aatgttcaca tggagtccga ggtttatgac
421 accccagaga acatcgtgca cggcagtgga
agccagcttt ttgatcatgt tgctgagtgc
481 ctgggagatt tcatggagaa aaggaagatc
aaggacaaga agttacctgt gggattcacg
541 ttttcttttc cttgccaaca atccaaaata
gatgaggcca tcctgatcac ctggacaaag
601 cgatttaaag cgagcggagt ggaaggagca
gatgtggtca aactgcttaa caaagccatc
661 aaaaagcgag gggactatga tgccaacatc
gtagctgtgg tgaatgacac agtgggcacc
721 atgatgacct gtggctatga cgaccagcac
tgtgaagtcg gcctgatcat cggcactggc
781 accaatgctt gctacatgga ggaactgagg
cacattgatc tggtggaagg agacgagggg
841 aggatgtgta tcaatacaga atggggagcc
tttggagacg atggatcatt agaagacatc
901 cggacagagt ttgacaggga gatagaccgg
ggatccctca accctggaaa acagctgttt
961 gagaagatgg tcagtggcat gtacttggga
gagctggttc gactgatcct agtcaagatg
1021 gccaaggagg gcctcttatt tgaagggcgg atcaccccgg
agctgctcac ccgagggaag
1081 tttaacacca gtgatgtgtc agccatcgaa aagaataagg
aaggcctcca caatgccaaa
1141 gaaatcctga cccgcctggg agtggagccg tccgatgatg
actgtgtctc agtccagcac
1201 gtttgcacca ttgtctcatt tcgctcagcc aacttggtgg
ctgccacact gggcgccatc
1261 ttgaaccgcc tgcgtgataa caagggcaca cccaggctgc
ggaccacggt tggtgtcgac
1321 ggatctcttt acaagacgca cccacagtat tcccggcgtt
tccacaagac tctaaggcgc
1381 ttggtgccag actccgatgt gcgcttcctc ctctcggaga
gtggcagcgg caagggggct
1441 gccatggtga cggcggtggc ctaccgcttg gccgagcagc
accggcagat agaggagacc
1501 ctggctcatt tccacctcac caaagacatg ctgctggagg
tgaagaagag gatgcgggcc
1561 gagatggagc tggggctgag gaagcagacg cacaacaatg
ccgtggttaa gatgctgccc
1621 tccttcgtcc ggagaactcc cgacgggacc gagaatggtg
acttcttggc cctggatctt
1681 ggaggaacca atttccgtgt gctgctggtg aaaatccgta
gtgggaaaaa gagaacggtg
1741 gaaatgcaca acaagatcta cgccattcct attgaaatca
tgcagggcac tggggaagag
1801 ctgtttgatc acattgtctc ctgcatctct gacttcttgg
actacatggg gatcaaaggc
1861 cccaggatgc ctctgggctt cacgttctca tttccctgcc
agcagacgag tctggacgcg
1921 ggaatcttga tcacgtggac aaagggtttt aaggcaacag
actgcgtggg ccacgatgta
1981 gtcaccttac taagggatgc gataaaaagg agagaggaat
ttgacctgga cgtggtggct
2041 gtggtcaacg acacagtggg caccatgatg acctgtgctt
atgaggagcc cacctgtgag
2101 gttggactca ttgttgggac cggcagcaat gcctgctaca
tggaggagat gaagaacgtg
2161 gagatggtgg agggggacca ggggcagatg tgcatcaaca
tggagtgggg ggcctttggg
2221 gacaacgggt gtctggatga tatcaggaca cactacgaca
gactggtgaa cgaatattcc
2281 ctaaatgctg ggaaacaaag gtatgagaag atgatcagtg
gtatgtacct gggtgaaatc
2341 gtccgcaaca tcttaatcga cttcaccaag aagggattcc
tcttccgagg gcagatctct
2401 gagacgatga agacccgggg catctttgag accaagtttc
tctctcagat cgagagtgac
2461 cgattagcac tgctccaggt ccgggctatc ctccagcagc
taggtctgaa tagcacctgc
2521 gatgacagta tcctcgtcaa gacagtgtgc ggggtggtgt
ccaggagggc cgcacagctg
2581 tgtggcgcag gcatggctgc ggttgtggat aagatccgcg
agaacagagg actggaccgt
2641 ctgaatgtga ctgtgggagt ggacgggaca ctctacaagc
ttcatccaca cttctccaga
2701 atcatgcacc agacggtgaa ggaactgtca ccaaaatgta
acgtgtcctt cctcctgtct
2761 gaggatggca gcggcaaggg ggccgccctc atcacggccg
tgggcgtgcg gttacgcaca
2821 gaggcaagca gctaagagtc cgggatcccc agcctactgc
ctctccagca cttctctctt
2881 caagcggcga ccccctaccc tcccagcgag ttgcgctggg
agacgctggc gccagggcct
2941 gccggcgcgg ggaggaaagc aaaatccaac taatggtata
tattgtaggg tacagaatag
3001 agcgtgtgct gttgataata tctctcaccc ggatccctcc
tcacttgccc tgccactttg
3061 catggtttga ttttgacctg gtcccccacg tgtgaagtgt
agtggcatcc atttctaatg
3121 tatgcattca tccaacagag ttatttattg gctggagatg
gaaaatcaca ccacctgaca
3181 ggccttctgg gcctccaaag cccatccttg gggttccccc
tccctgtgtg aaatgtatta
3241 tcaccagcag acactgccgg gcctccctcc cgggggcact
gcctgaaggc gagtgtgggc
3301 atagcattag ctgcttcctc ccctcctggc acccactgtg
gcctggcatc gcatcgtggt
3361 gtgtcaatgc cacaaaatcg tgtgtccgtg gaaccagtcc
tagccgcgtg tgacagtctt
3421 gcattctgtt tgtctcgtgg ggggaggtgg acagtcctgc
ggaaatgtgt cttgtcttcc
3481 atttggataa aaggaaccaa ccaacaaaca atgccatcac
tggaatttcc caccgctttg
3541 tgagccgtgt cgtatgacct agtaaacttt gtaccaattc