LOCUS       HUMADA       1478 bp    mRNA            PRI       30-OCT-1994
DEFINITION  Human adenosine deaminase mRNA, complete cds.
ACCESSION   K02567
NID         g178074
KEYWORDS    adenosine deaminase.
SOURCE      Human T-cell (cell line HPB ALL), cDNA to mRNA, clones E3, A3 and
            C10.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Daddona,P.E., Shewach,D.S., Kelley,W.N., Argos,P., Markham,A.F. and
            Orkin,S.H.
  TITLE     Human adenosine deaminase. cDNA and complete primary amino acid
            sequence
  JOURNAL   J. Biol. Chem. 259 (19), 12101-12106 (1984)
  MEDLINE   85006946
COMMENT     A potential polyadenylation signal is present at position
            1450-1455.  The sequence below begins 10-15 bp downstream of the
            mRNA cap site.
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     mRNA            <1..1478
                     /note="ADA mRNA"
     gene            77..1168
                     /gene="ADA"
     CDS             77..1168
                     /gene="ADA"
                     /note="adenosine deaminase"
                     /codon_start=1
                     /db_xref="GDB:G00-119-649"
                     /db_xref="PID:g178075"
                     /translation="MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAE
                     GLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRY
                     SPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPN
                     WSPKVVELCKNYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEV
                     GSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDT
                     EHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSF
                     LPEDEKRELLDLLYKAYGMPPSASAGQNL"
BASE COUNT      358 a    431 c    412 g    277 t
ORIGIN      18 bp upstream of HpaII site.
        1 gccgagcggc caccgagccg gcagagaccc accgagcggc ggcggaggga gcagcgccgg
       61 ggcgcacgag ggcaccatgg cccagacgcc cgccttcgac aagcccaaag tagaactgca
      121 tgtccaccta gacggatcca tcaagcctga aaccatctta tactatggca ggaggagagg
      181 gatcgccctc ccagctaaca cagcagaggg gctgctgaac gtcattggca tggacaagcc
      241 gctcaccctt ccagacttcc tggccaaatt tgactactac atgcctgcta tcgcgggctg
      301 ccgggaggct atcaaaagga tcgcctatga gtttgtagag atgaaggcca aagagggcgt
      361 ggtgtatgtg gaggtgcggt acagtccgca cctgctggcc aactccaaag tggagccaat
      421 cccctggaac caggctgaag gggacctcac cccagacgag gtggtggccc tagtgggcca
      481 gggcctgcag gagggggagc gagacttcgg ggtcaaggcc cggtccatcc tgtgctgcat
      541 gcgccaccag cccaactggt cccccaaggt ggtggagctg tgtaagaact accagcagca
      601 gaccgtggta gccattgacc tggctggaga tgagaccatc ccaggaagca gcctcttgcc
      661 tggacatgtc caggcctacc aggaggctgt gaagagcggc attcaccgta ctgtccacgc
      721 cggggaggtg ggctcggccg aagtagtaaa agaggctgtg gacatactca agacagagcg
      781 gctgggacac ggctaccaca ccctggaaga ccaggccctt tataacaggc tgcggcagga
      841 aaacatgcac ttcgagatct gcccctggtc cagctacctc actggtgcct ggaagccgga
      901 cacggagcat gcagtcattc ggctcaaaaa tgaccaggct aactactcgc tcaacacaga
      961 tgacccgctc atcttcaagt ccaccctgga cactgattac cagatgacca aacgggacat
     1021 gggctttact gaagaggagt ttaaaaggct gaacatcaat gcggccaaat ctagtttcct
     1081 cccagaagat gaaaagaggg agcttctcga cctgctctat aaagcctatg ggatgccacc
     1141 ttcagcctct gcagggcaga acctctgaag acgccactcc tccaagcctt caccctgtgg
     1201 agtcacccca actctgtggg gctgagcaac atttttacat ttattccttc caagaagacc
     1261 atgatctcaa tagtcagtta ctgatgctcc tgaaccctat gtgtccattt ctgcacacac
     1321 gtatacctcg gcatggccgc gtcacttctc tgattatgtg ccctggcagg gaccagcgcc
     1381 cttgcacatg ggcatggttg aatctgaaac cctccttctg tggcaacttg tactgaaaat
     1441 ctggtgctca ataaagaagc ccatggctgg tggcatgc
//