A Brief History of the Opioids
(Part 1)
Humans have used opium for its mind altering effects longer than any drug other than alcohol.  Written records indicate that inhabitants of the Middle East used opium as early as 4000 B.C.  The ancient Greeks and Romans, fully aware of opium's dual effects of pain relief and euphoric rush, ingested the drug for medical treatment and recreational purposes. In The Odyssey, Homer describes a warm, sleepy feeling caused by a plant-derived drug that closely matches the properties of opium.  Hippocrates and Galen, two of the most prominent Greek physicians, employed opium to battle headaches, coughing, asthma and melancholy.  In the first century A.D., poppy extract inherited the name "opius," which is Greek for "little juice" (Snyder, 1989).

In 1805, German chemist Friedrich Serturner isolated the pure active ingredient in opium.  He named this chemical morphine, after Morpheus, the Greek god of dreams.  Serturner's discovery was the first isolation of an active ingredient from any drug.  He proved that pure chemicals within plants are what interact with the body to cause internal physiological changes.  The pharmaceutical industry arose from his discovery (Iversen, 1996).


Opium is a gummy substance that is
extracted from the poppy plant. Image 
from  Snyder, 1996.  Used with 
permission by W.H. Freeman and 
Company.

A hypodermic syringe with a sample of heroin, a drug 
related to opium. Image used with permission from the
Greater Manchester Police. 
During the second half of the nineteenth century, opioid abuse became prevalent.  In 1853, Dr. Alexander Wood invented the hypodermic syringe, which could be used to inject opium directly into the blood stream.  Injection causes more rapid and potent effects than ingestion, because the digestive system breaks down some morphine before it enters the blood.  Morphine was used so often to relieve pain during the American Civil War that thousands of soldiers developed addictions to the drug. Opioid addiction became known as the "soldiers disease" (Snyder 1989).
Continue: The History of Opioids (part 2)


    Main Page   History 2    Ligands & Receptors  Endorphins   Opiate Receptors    Analgesia 1  Analgesia 2   Euphoria  Tolerance & Dependency   Common Opioids   Current Research   Acknowledgments  Literature Cited

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  This site was created during the fall semester of 1999 by Wes Self, a student at 
  Davidson College, as part of an assignment in Biology 312 (Animal Physiology). 

  Questions, comments and suggestions are appreciated at weself@davidson.edu