LH4

Function

The late H4 (LH4) gene is a member of the late histone genes subtype.
There are 5-10 copies of the late histone genes per genome and their organization is very different from the early genes.
The number of late H4 genes may vary from individual to individual (Kaumeyer at al., 1986).

Protein

Histone protein
SWISS_PROT: P02306

Subcellular location

Unlike the bulk maternal mRNA pool, histone mRNA is located almost exclusively within the egg nucleus, suggesting that the egg selectively retains the stored pool of histone mRNPs within the nuclear membrane while allowing newly synthesized mRNAs, including histone transcripts, to pass into the egg cytoplasm (DeLeon et al., 1983; Showman et al., 1982; Venezky et al., 1981). The stored histone mRNPs remain within the egg nucleus until fertilization initiates egg cleavage (Maxson et al., 1983).