LOCUS SPU17164 3617 bp mRNA INV 15-AUG-1996
DEFINITION Strongylocentrotus purpuratus fibroblast growth factor receptor (SpFGFR)
mRNA, complete cds.
ACCESSION U17164
NID g596008
KEYWORDS .
SOURCE purple urchin.
ORGANISM Strongylocentrotus purpuratus
Eukaryotae; mitochondrial eukaryotes; Metazoa; Echinodermata;
Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida;
Strongylocentrotidae; Strongylocentrotus.
REFERENCE 1 (bases 1 to 3617)
AUTHORS McCoon,P.E., Angerer,R.C. and Angerer,L.M.
TITLE SpFGFR, a new member of the fibroblast growth factor receptor
family, is developmentally regulated during early sea urchin
development
JOURNAL J. Biol. Chem. 271 (33), 20119-20125 (1996)
MEDLINE 96355324
REFERENCE 2 (bases 1 to 3617)
AUTHORS Angerer,R.C.
TITLE Direct Submission
JOURNAL Submitted (15-NOV-1994) Robert C. Angerer, Biology, University of
Rochester, 315 Hutchison Hall, River Campus, Rochester, NY 14627,
USA
FEATURES Location/Qualifiers
source 1..3617
/organism="Strongylocentrotus purpuratus"
/db_xref="taxon:7668"
/clone="SpFGFR"
/dev_stage="blastula through pluteus stages"
5'UTR <1..426
CDS 427..3345
/note="FGF receptor"
/codon_start=1
/product="fibroblast growth factor receptor precursor"
/db_xref="PID:g596009"
/translation="MSLPRCPRTRTVMFSRTLTRCYPQRTLWIAILCVICSWTLSTAG
ATTIRDKEVKPDAPQDLTAIPVKAEAIVLTWKKPLKGQTDGYIVVYCLKRNKGNGCER
QKIEGGNVTEVEVTNLYANHTYQFQVQSWYSDHPKGASTGYIEASGTPPIPPTLRRNF
KGLVEKSLGFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTKTSIVFKRLRF
SDAGLYTCVASNFFGQPIHVNFTLIVVDTHSESYAESSVLESFSSLELETGPYNETEE
EETHFPRFTDTERMEPEKPLPSNTKVRLECGARGTPTPNITWIKDGVQKWKINVIRPT
RVEEKGFVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKIRERLPVKPIMSPMKNVT
ATVGSNTSFVCRVVNDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTC
DEFLDVFYQNQSKRMLECLHLIQLETQGGMEEANQLKLYNVQYEDEGPYLCVAGNFYG
MSWEGAYLDVVEPTTQAPVRTNPPAVYIPNNMQPTSKTQLIIFSVVGFVVVLILVTCI
AILCKQTQVRHRRPSDKPDISGPKHLYRQTSVDSTQSIAPLFGGRNRLTSSLTVISEY
DIPLDPEWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDR
EFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPEE
YEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKIC
DFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGG
TPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDR
IISVSSNQDYLDLEAVGDAPVKTFQESERMAFMGFRAPLSPQVYYKVPQTRDCCPYAN
"
sig_peptide 427..546
mat_peptide 547..3342
/product="fibroblast growth factor receptor"
misc_feature 952..1104
/note="encodes Ig1 region"
misc_feature 1249..1260
/note="encodes acid box"
misc_feature 1342..1500
/note="encodes Ig2 region"
misc_feature 1633..1929
/note="encodes Ig3 region"
misc_feature 2068..2133
/note="encodes transmembrane region"
misc_feature 2134..2337
/note="encodes juxtamembrane region"
misc_feature 2338..3168
/note="encodes tyrosine kinase (TK) domain"
misc_feature 2362..2379
/note="encodes ATP binding site"
misc_feature 2644..2682
/note="encodes kinase insert region"
misc_feature 2860..2862
/note="encodes tyrosine which is phosphorylated upon
receptor activation"
misc_feature 3196..3198
/note="encodes tyrosine which is phosphorylated upon
receptor activation"
3'UTR 3346..>3616
BASE COUNT 1038 a 792 c 841 g 946 t
ORIGIN
1 ctacatttga cttctttgct ctgtttggat tcatggattt ttataaagtg tggatgtgat
61 caagctttct aggattgttt caattcattg actgcatctg gatgatgtac ttcatgatat
121 aaagcttcga atccatggta aagaaaagga catcagtgaa caccatgttc ataatgttgc
181 tggaatgatg acattgactg ttaaaaagat gtttgctgat attaaactct ggctgtagca
241 actttggagt tgacgtggaa taaatttgta gacaacttga ctggattctc gtgaaattga
301 accaaaatca acgacacccg gagtgaggaa tacactgttg gcagagagtc cgtgagggct
361 tatcaagtac tgcattttct tctgtcacag ttttgtgaaa actatgcttc ggtcagccac
421 ggcatcatga gtctgccgcg ttgtccgagg acacgtaccg tcatgttttc tagaactttg
481 actcgttgtt atcctcaaag aacgctttgg attgcgatat tatgtgtaat atgcagttgg
541 acgttatcaa cggctggagc aactacaata cgagataaag aagtaaaacc agacgctcct
601 caggatctga cagccatccc agtcaaagca gaagccattg ttttaacatg gaaaaaacca
661 ttaaaaggac aaacagatgg atacattgtt gtatattgtc tcaagagaaa caaaggtaat
721 ggatgcgaaa gacagaagat tgaaggaggc aacgtgaccg aggttgaagt caccaattta
781 tatgcaaacc acacatacca attccaggtg caatcctggt actcagacca tccaaaagga
841 gcatctacag gctatataga ggcatcagga acaccaccaa taccaccgac cttgagacgt
901 aactttaaag gtttggttga gaagagcctt ggttttgagc acaagatacc atgtccagtg
961 aaagctgatc ccagacccta cacaagatgg ttgaagaatg gtactgatct cacacccaat
1021 gaccccgatg ataatgtgtc tttcaccaag acatccatag tcttcaagcg gcttaggttc
1081 tctgatgcag gcctgtatac ctgtgtggca tccaactttt ttggtcaacc cattcatgtc
1141 aacttcactc tcatagtagt tgacacacat tcagagtctt atgcggaatc cagtgtcctg
1201 gaatccttct cctcattgga gttagagact ggcccataca atgagacgga agaggaagag
1261 acgcacttcc ccaggttcac agacactgaa cgtatggagc cagagaagcc cttgcccagt
1321 aacaccaagg tcaggctgga gtgtggcgct agaggcacac ctacaccaaa cattacctgg
1381 atcaaagatg gcgttcagaa gtggaagatc aatgtcatta gacctacaag ggttgaggag
1441 aaaggttttg ttctgatcat ccgtcgagct attgttagag acactggcaa gtacacctgc
1501 attgttagca accagtatgg caccattgag catacctatg atgtcaagat cagagaacga
1561 ctgcctgtga agcctatcat gtcacctatg aagaatgtga ctgccactgt gggctccaac
1621 acctcgtttg tgtgtagggt tgtgaatgac cttacgccac actttgcctg gatgcgcttc
1681 aatggaacca acaacaccaa acaacgtctc acagacattg atgaccatat cagtattcta
1741 cagcaacgat gggtcgagga gccaatgctg acttgcgacg agttcctgga tgtcttttac
1801 caaaaccagt caaagaggat gctagaatgt cttcatctga ttcagcttga aactcaagga
1861 ggaatggagg aagctaacca actgaagctc tacaatgtcc agtatgaaga tgaaggccca
1921 tatctatgtg tcgcaggaaa cttctatggc atgagctggg aaggagcata tctagacgta
1981 gtagaaccta ctacccaagc tccagtgaga accaatcctc ctgcagtcta catcccaaac
2041 aacatgcagc caacgagcaa gactcagctt attatcttca gtgttgtagg gtttgttgtg
2101 gtgctcattc tggtcacgtg tatagctatc ttgtgtaagc agacccaggt tagacatcgt
2161 agaccttcgg acaaaccaga catcagtggg cctaaacatc tctatagaca gacgtcggtt
2221 gactccaccc agtctattgc tcccctgttt ggggggcgga atcgactaac atcatcactt
2281 acggtgatct ccgaatacga catccctctt gatcctgagt gggagttccc tcgagacaga
2341 cttaccgttg ggaaaaccat tggagaaggt gcgtttggta aggtagtgat tggagaggca
2401 gttggtatcg tctgccagga gaagactagc accgtggctg tcaagatgct caaagccaat
2461 gcgatggacc gcgagttctc tgatctgatc tcggagctgg ctatgatgaa gatgattggc
2521 aagaatccta acatcatcaa tctgcttgga tgctgtacac aagaaggtcc cccatatgtc
2581 attgttgagt ttgctcacca tggcaaccta cgagacttcc tgcgctcaag acgtccacct
2641 gaagaatatg agaagtctat cctactgacg acctctcaga cgctgaccaa taaagacttg
2701 atgtctatgg cttaccaggt ggctagaggc atggatttcc tcgcttccaa aaagtgcatt
2761 catcgagatt tagctgcaag gaatgttcta gtgaccgaag actttgagat gaagatctgt
2821 gattttggac ttgcccgtga tatccactac attgacttct acagaaagac tacagatggt
2881 cggttaccag tgaaatggat ggctcctgaa gctctgtttg atcgaatgtt caccactcag
2941 agtgatgtat ggtcatttgg tatcctcctg tgggagatca tgacgttagg aggtaccccg
3001 taccctagcg ttcccgttga acagatgttt gactacctac gctcaggcaa gagattggag
3061 aaacctcaaa acacctcact agaaatctat catatcttat gtgagtgttg gagaacatca
3121 ccgggacaga gaccaacgtt ctgtgagctg gtagaagatc tggatcgtat catctcagtc
3181 tcatcaaatc aggattatct tgatctggaa gcagtgggtg atgcaccagt caaaaccttt
3241 caagagagcg agcgaatggc ttttatggga ttcagggcgc cgctctcacc gcaggtttat
3301 tacaaagtac cacaaactcg agactgttgt ccgtatgcta actgatggca gaagtcgaat
3361 tacaatgcag gacaaagcat ctggtatgca attcattttg tgttttcatt tgccgcttca
3421 gacttattca gtttgtttcg ttcctttgtg gaaatgtttt tctttggtgc tactgaatga
3481 ccggtgaatg tgaaataatg gaactctgat tgagcaatgc ccgcccgcca acgtatactg
3541 caatagactc tcacatatag cgtatataga agatggagaa tcaaggagaa tctaacatga
3601 aagcatcgta cgagata
//