Gene Networks Database
Strongylocentrotus purpuratus Genes in Development:
The early H4 (EH4) gene is a member of the early histone genes subtype.
Early histone genes are reiterated several hundred-fold per haploid genome
in a tandem array (Lee et al., 1991).
Unlike the bulk maternal mRNA pool, histone mRNA is located
almost exclusively within the egg nucleus, suggesting that the
egg selectively retains the stored pool of histone mRNPs within the
nuclear membrane while allowing newly synthesized mRNAs, including
histone transcripts, to pass into the
egg cytoplasm (DeLeon et al., 1983; Showman et al., 1982; Venezky et al., 1981).
The stored histone mRNPs remain within the egg nucleus until
fertilization initiates egg cleavage (Maxson et al., 1983).
The amount of EH4 mRNA increases approximately 10-fold from the
16-cell stage to early blastula and then decreases rapidly
so that little EH4 mRNA remains by the gastrula stage.
The levels of mRNA do not appear to be identical for
each batch of embryos studied, making a generalization
about exact level of increase impossible (Weinberg et al., 1983).
Method 1: RNA blot hybridization
Reference: Weinberg et al., 1983
- LH4 Strongylocentrotus purpuratus
- EH4 Paracentrotus lividus
- EH4 Psammechinus miliaris
- H4 Xenopus
- H4 Chicken
- H4 Human
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