Gene Networks Database
erythrogramma Genes in Development: Wnt genes
HeWnt-4 is a member of the Wnt gene family, one of the principal families of secreted
signaling molecules that orchestrate the development of both
invertebrate and vertebrete embryos.
Southern blot analysis demonstrated that HeWnt-4 is a single copy gene (Ferkowicz et al., 1998).
HeWnt-4 is a cell signaling protein.
All idetified sea urchin Wnt sequences contain nine absolutely
conserved cysteine residues and a potential N-linked glycosylation sequence (Ferkowicz et al., 1998).
Wnt proteins are secreted and do not diffuse more than a few cell diametres from Wnt-expressing cells (Nusse and Varmus, 1992, Siegfried and Perrimon, 1994).
The pattern of HeWnt-4 transcript accumulation is similar to that
of HeWnt-5, albeit at a slightly lower level.
HeWnt-4 expression is first detectable at the mesenchyme blastula stage
and continues to be expressed at a similar level throughout
gastrulation. The abundance of HeWnt-4 transcripts declines by the early
larval stage, similar to that of the HeWnt-5
transcripts. Also like HeWnt-5, there is
a second phase of higher expression by the midlarval stage
through metamorphosis in H. erythrogramma.
These stages are dominated by the precocious development
of the adult rudiment in this species (Ferkowicz et al., 1998).
Method 1: RNase protection assay
Reference: Ferkowicz et al., 1998
||36-h early larva
||70-h late larva
||94-h metamorphosing juvenile
- HeWnt-5 H. erythrogramma
- SpWnt-1 S. purpuratus
- SpWnt-4 S. purpuratus
- SpWnt-5 S. purpuratus
- HtWnt-5 H. tuberculata
- Wnt genes Mus musculus
- Wnt genes Xenopus laevis
- Wnt genes Evasterias troschelii
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Comments are welcome to Sveta Surkova
Copyright © 1997 GeNet Team