SpHbox7

Function

SpHbox7 is one of at least two Abd-B-like genes in the S. purpuratus genome. SpHbox7 patricipates in the patterning of the gut, the mesoderm, and the oral surface (Dobias et al., 1996).

Protein

Homeodomain protein
GenBank: 2809211

Subcellular location

Cytoplasmic

Expression Pattern

SpHbox7 transcripts are first detectable in midblastula stage embryos, increase in amount during gastrulation, decline slightly by the pluteus stage, and are not detectable in any tissue of the adult. Whole mount in situ hybridization and antibody staining with an SpHbox7-specific antibody reveal that both SpHbox7 mRNA and protein are present throughout the embryo in the blastula. Subsequently, they are localized in the invaginating archenteron, secondary mesenchyme, and oral ectoderm. By the pluteus larva stage, SpHbox7 protein and mRNA are present in the gut, larval arms, and portions of the oral ectoderm (Dobias et al., 1996).

mRNA level

Temporal accumulation
Method: Whole mount in situ hybridization and antibody staining with an SpHbox7-specific antibody
Reference: Dobias et al., 1996

Stage Midblastula Gastrula Pluteus

Level + + +

Spatial localization
Method: Whole mount in situ hybridization and antibody staining with an SpHbox7-specific antibody
Reference: Dobias et al., 1996

Stage Gastrula Pluteus

Tissue Invaginating archenteron, secondary mesenchyme, and oral ectoderm gut, larval arms, and portions of the oral ectoderm

Sequences

GenBank:

mRNA, complete cds

Regulatory Regions

Regions

Regulatory Connections

Upstream Genes

SpHbox7

Downstream Genes

Evolutionary Homologies

Links

Urchin Web

Bibliography

UrchiNet

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Stage	Gastrula	Pluteus
Tissue	Invaginating archenteron, secondary mesenchyme, and oral ectoderm	gut, larval arms, and portions of the oral ectoderm