Gene Networks Database

SpSHR2 - CyIIIb interaction

• REGULATOR: SpSHR2
• TARGET: CyIIIb
• INTERACTION TYPE: protein-DNA
• INTERACTION RESULT: repression
• TISSUE: secondary mesenchyme, endoderm
• STAGE: blastula, pluteus
• TARGET SITE: TGACCCGCTGACCT
• PROOFS: in vitro translation, DNA binding assay, EMSA, whole-mount in situ hybridization of the fusion constructs
• REFERENCES: Xu et al., 1996; Kontrogianni-Konstantopoulos et. al., 1996
• COMMENTS: SpSHR2 binds to the C1R element of CyIIIb promoter, which is suffisient for repression of CyIIIb expression in meso/endodermal cells.