Score E
Sequences producing significant alignments: (bits) Value
sp|P08200|IDH_ECOLI ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 819 0.0
pdb|6ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutan... 817 0.0
pdb|7ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutan... 817 0.0
pdb|1IDD| Isocitrate Dehydrogenase Y160f Mutant Apo Enzy... 817 0.0
pdb|1IDC| Isocitrate Dehydrogenase From E.Coli (Mutant K... 816 0.0
pdb|1CW7|A Chain A, Low Temperature Structure Of Wild-Type ... 816 0.0
pdb|1BL5| Isocitrate Dehydrogenase From E. Coli Single T... 815 0.0
pdb|1GRP| Oxidoreductase, Nadp, Phosphorylation, Glyoxyl... 814 0.0
pdb|4ICD| Phosphorylated Isocitrate Dehydrogenase (E.C.1... 814 0.0
pdb|1GRO| Oxidoreductase, Nadp, Phosphorylation, Glyoxyl... 813 0.0
pdb|1ISO| Isocitrate Dehydrogenase: Structure Of An Engi... 798 0.0
gb|AAC45887.1| (AF017587) isocitrate dehydrogenase [Escheri... 796 0.0
gb|AAC45891.1| (AF017591) isocitrate dehydrogenase [Escheri... 793 0.0
gb|AAC45888.1| (AF017588) isocitrate dehydrogenase [Escheri... 793 0.0
gb|AAC45898.1| (AF017598) isocitrate dehydrogenase [Escheri... 792 0.0
gb|AAC45897.1| (AF017597) isocitrate dehydrogenase [Escheri... 790 0.0
gb|AAC45904.1| (AF017604) isocitrate dehydrogenase [Salmone... 749 0.0
gb|AAC45918.1| (AF017618) isocitrate dehydrogenase [Salmone... 748 0.0
gb|AAC45905.1| (AF017605) isocitrate dehydrogenase [Salmone... 747 0.0
gb|AAC45920.1| (AF017620) isocitrate dehydrogenase [Citroba... 747 0.0
gb|AAC45916.1| (AF017616) isocitrate dehydrogenase [Salmone... 746 0.0
gb|AAC45910.1| (AF017610) isocitrate dehydrogenase [Salmone... 746 0.0
gb|AAC45912.1| (AF017612) isocitrate dehydrogenase [Salmone... 745 0.0
gb|AAC45908.1| (AF017608) isocitrate dehydrogenase [Salmone... 744 0.0
gb|AAF16735.1|AF146294_1 (AF146294) isocitrate dehydrogenas... 618 e-176
gb|AAF16734.1|AF146293_1 (AF146293) isocitrate dehydrogenas... 618 e-176
sp|P41560|IDH1_VIBA1 ISOCITRATE DEHYDROGENASE [NADP] 1 (OXA... 617 e-176
gb|AAF16733.1|AF146292_1 (AF146292) isocitrate dehydrogenas... 616 e-175
gb|AAC68600.1| (AF069035) isocitrate dehydrogenase [Coxiell... 616 e-175
gb|AAF16726.1|AF146285_1 (AF146285) isocitrate dehydrogenas... 615 e-175
gb|AAF16738.1|AF146297_1 (AF146297) isocitrate dehydrogenas... 615 e-175
gb|AAF16731.1|AF146290_1 (AF146290) isocitrate dehydrogenas... 615 e-175
gb|AAF16736.1|AF146295_1 (AF146295) isocitrate dehydrogenas... 613 e-175
gb|AAF16730.1|AF146289_1 (AF146289) isocitrate dehydrogenas... 613 e-175
gb|AAF16737.1|AF146296_1 (AF146296) isocitrate dehydrogenas... 613 e-175
gb|AAF16727.1|AF146286_1 (AF146286) isocitrate dehydrogenas... 610 e-174
gb|AAF16732.1|AF146291_1 (AF146291) isocitrate dehydrogenas... 609 e-173
pir||E71982 isocitrate dehydrogenase - Helicobacter pylori ... 578 e-164
sp|P56063|IDH_HELPY ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 577 e-164
gb|AAB39334.1| (U55996) isocitrate dehydrogenase [Thermus a... 557 e-158
pir||D75382 isocitrate dehydrogenase - Deinococcus radiodur... 552 e-156
sp|P39126|IDH_BACSU ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 538 e-152
emb|CAA73794.1| (Y13358) isocitrate dehyrogenase [Bacillus ... 534 e-151
sp|P50214|IDH_ANASP ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 451 e-126
pir||G69330 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) ... 434 e-120
sp|Q59940|IDH_STRMU ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 431 e-120
pir||S74684 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) ... 427 e-118
sp|Q59985|IDH_STRSL ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 421 e-117
sp|P80046|IDH_SYNY3 ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 416 e-115
pir||A72658 probable isocitrate dehydrogenase APE0689 - Aer... 358 6e-98
dbj|BAA13177.2| (D86855) isocitrate dehydrogenase [Caldococ... 344 7e-94
sp|O67480|IDH_AQUAE ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 339 3e-92
gb|AAC44503.1| (U48886) isocitrate dehydrogenase [Streptoco... 226 4e-58
sp|P33197|IDH_THETH ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 179 4e-44
pir||A43934 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) ... 179 4e-44
gb|AAF48965.1| (AE003512) CG12233 gene product [Drosophila ... 162 7e-39
sp|Q9ZDR0|IDH_RICPR ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 158 1e-37
gb|AAC69609.1| (AF045154) NAD-dependent isocitrate dehydrog... 148 9e-35
pir||A69113 isocitrate dehydrogenase - Methanobacterium the... 145 6e-34
sp|Q93714|IDHA_CAEEL PROBABLE ISOCITRATE DEHYDROGENASE [NAD... 145 6e-34
ref|NP_014779.1|IDH2| NAD+-dependent isocitrate dehydrogena... 143 2e-33
emb|CAA74776.1| (Y14431) NAD-dependent isocitrate dehydroge... 142 5e-33
emb|CAB83285.1| (AL162751) 3-isopropylmalate dehydrogenase-... 141 1e-32
sp|Q58991|IDH_METJA ISOCITRATE DEHYDROGENASE [NADP] (OXALOS... 141 1e-32
pir||C64499 isocitrate dehydrogenase (EC 1.1.1.-) - Methano... 140 3e-32
dbj|BAA88179.1| (AP000836) ESTs C19133(E10008),AU058199(E50... 139 4e-32
pir||T03406 probable isocitrate dehydrogenase (NAD+) (EC 1.... 139 4e-32
pir||T06131 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) c... 138 1e-31
gb|AAC49964.1| (U81993) NAD+ dependent isocitrate dehydroge... 138 1e-31
sp|O27441|LEU3_METTH 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 137 2e-31
sp|Q58130|LEU3_METJA 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 136 4e-31
pir||H64389 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) ... 136 4e-31
pir||S30897 3-isopropylmalate dehydrogenase (EC 1.1.1.85) p... 136 5e-31
emb|CAB62099.1| (AL133306) probable isocitrate dehydrogenas... 135 9e-31
sp|P29696|LEU3_SOLTU 3-ISOPROPYLMALATE DEHYDROGENASE PRECUR... 134 1e-30
gb|AAB81675.1| (AC002354) putative NAD+ dependent isocitrat... 134 2e-30
gb|AAC49965.1| (U81994) NAD+ dependent isocitrate dehydroge... 134 2e-30
pir||T04670 isocitrate dehydrogenase (NAD+) homolog F8D20.1... 133 3e-30
gb|AAF23254.1|AC015985_12 (AC015985) putative isocitrate de... 132 8e-30
emb|CAA74777.1| (Y14432) NAD-dependent isocitrate dehydroge... 131 1e-29
emb|CAB57580.1| (Y18930) 3-isopropylmalate dehydrogenase [S... 126 3e-28
pir||T37546 probable isocitrate dehydrogenase (NAD+) (EC 1.... 124 1e-27
sp|O29627|LEU3_ARCFU 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 123 3e-27
gb|AAB63461.1| (AF009036) NAD(+)-isocitrate dehydrogenase s... 123 4e-27
gb|AAC69608.1| (AF045153) NAD-dependent isocitrate dehydrog... 118 1e-25
ref|NP_012172.1|LYS12| Homo-isocitrate dehydrogenase; Lys12... 117 2e-25
sp|P50455|LEU3_SULS7 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 115 8e-25
pir||E75368 probable isocitrate dehydrogenase - Deinococcus... 114 1e-24
pir||D75045 3-isopropylmalate dehydrogenase (leub) PAB2424 ... 111 9e-24
dbj|BAA35996.1| (D90750) Isocitrate dehydrogenase (NADP+) (... 110 3e-23
gb|AAC48877.1| (AF017621) isocitrate dehydrogenase [Bacteri... 110 3e-23
sp|P95313|LEU3_MYCTU 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 109 4e-23
sp|P94631|LEU3_CORGL 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 108 8e-23
sp|O66607|LEU3_AQUAE 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 108 1e-22
sp|P94929|LEU3_MYCBO 3-ISOPROPYLMALATE DEHYDROGENASE (BETA-... 107 2e-22
gb|AAD55084.1| (AF176568) isocitrate dehydrogenase gamma su... 107 2e-22
pir||T29052 3-isopropylmalate dehydrogenase (EC 1.1.1.85) -... 105 9e-22
ref|NP_014361.1|IDH1| alpha-4-beta-4 subunit of mitochondri... 104 2e-21
gb|AAD03852.1| (AF079317) 3-isopropylmalate dehydrogenase [... 102 5e-21
gb|AAF41430.1| (AE002453) 3-isopropylmalate dehydrogenase [... 101 1e-20
sp|P08200|IDH_ECOLI ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP) >gi|65942|pir||DCECIS
isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) -
Escherichia coli >gi|230885|pdb|3ICD| Isocitrate
Dehydrogenase (E.C.1.1.1.42) >gi|231153|pdb|5ICD|
Isocitrate Dehydrogenase (E.C.1.1.1.42) Complex With
Mg2+ And Isocitrate >gi|231328|pdb|9ICD| Isocitrate
Dehydrogenase (E.C.1.1.1.42) Complex With NADP+
>gi|576181|pdb|1IKA| Isocitrate Dehydrogenase
(E.C.1.1.1.42) Complexed With Alpha-Ketoglutarate
>gi|2624555|pdb|1AI3| Orbital Steering In The Catalytic
Power Of Enzymes: Small Structural Changes With Large
Catalytic Consequences >gi|2624869|pdb|1AI2| Isocitrate
Dehydrogenase Complexed With Isocitrate, Nadp+, And
Calcium (Flash-Cooled) >gi|2781105|pdb|1SJS| Access To
Phosphorylation In Isocitrate Dehydrogenase May Occur By
Domain Shifting >gi|146432|gb|AAA24006.1| (J02799)
isocitrate dehydrogenase (icd; EC 1.1.1.42) [Escherichia
coli] >gi|1651560|dbj|BAA35958.1| (D90748) Isocitrate
dehydrogenase (NADP) (EC 1.1.1.42) (oxalosuccinate
decarboxylase) (idh) (NADP+-specific icdh) (idp).
[Escherichia coli] >gi|1651566|dbj|BAA35967.1| (D90749)
Isocitrate dehydrogenase (NADP) (EC 1.1.1.42)
(oxalosuccinate decarboxylase) (idh) (NADP+-specific
icdh) (idp). [Escherichia coli]
>gi|1787381|gb|AAC74220.1| (AE000213) isocitrate
dehydrogenase, specific for NADP+ [Escherichia coli]
Length = 416
Score = 819 bits (2092), Expect = 0.0
Identities = 404/416 (97%), Positives = 404/416 (97%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|6ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser 113
Replaced By Asp) (S113D)
Length = 416
Score = 817 bits (2088), Expect = 0.0
Identities = 403/416 (96%), Positives = 403/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR LNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRDLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|7ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser 113
Replaced By Glu) (S113E) >gi|231302|pdb|8ICD|
Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser
113 Replaced By Glu) (S113E) Complex With Mg2+ And
Isocitrate
Length = 416
Score = 817 bits (2088), Expect = 0.0
Identities = 403/416 (96%), Positives = 403/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR LNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|1IDD| Isocitrate Dehydrogenase Y160f Mutant Apo Enzyme
>gi|1421633|pdb|1IDE| Isocitrate Dehydrogenase Y160f
Mutant Steady-State Intermediate Complex (Laue
Determination)
Length = 416
Score = 817 bits (2088), Expect = 0.0
Identities = 403/416 (96%), Positives = 404/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDI+AGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIFAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|1IDC| Isocitrate Dehydrogenase From E.Coli (Mutant K230m), Steady-State
Intermediate Complex Determined By Laue Crystallography
>gi|1421639|pdb|1IDF| Isocitrate Dehydrogenase K230m
Mutant Apo Enzyme >gi|5822037|pdb|1CW1|A Chain A,
Crystal Structure Of Isocitrate Dehydrogenase Mutant
K230m Bound To Isocitrate And Mn2+
>gi|5822038|pdb|1CW4|A Chain A, Crystal Structure Of
K230m Isocitrate Dehydrogenase In Complex With Alpha-
Ketoglutarate
Length = 416
Score = 816 bits (2086), Expect = 0.0
Identities = 403/416 (96%), Positives = 403/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVH GNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|1CW7|A Chain A, Low Temperature Structure Of Wild-Type Idh Complexed With
Mg-Isocitrate
Length = 416
Score = 816 bits (2086), Expect = 0.0
Identities = 403/416 (96%), Positives = 403/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAP YAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPAYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|1BL5| Isocitrate Dehydrogenase From E. Coli Single Turnover Laue
Structure Of Rate-Limited Product Complex, 10 Msec Time
Resolution
Length = 414
Score = 815 bits (2082), Expect = 0.0
Identities = 402/414 (97%), Positives = 402/414 (97%)
Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK
Sbjct: 1 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 60
Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122
ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL
Sbjct: 61 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 120
Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182
DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE
Sbjct: 121 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 180
Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242
MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK
Sbjct: 181 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 240
Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302
DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM
Sbjct: 241 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 300
Query: 303 NLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362
NLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEM
Sbjct: 301 NLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 360
Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 414
pdb|1GRP| Oxidoreductase, Nadp, Phosphorylation, Glyoxylate Bypass Mol_id:
1; Molecule: Isocitrate Dehydrogenase; Chain: Null; Ec:
1.1.1.42; Mutation: N115l
Length = 416
Score = 814 bits (2080), Expect = 0.0
Identities = 402/416 (96%), Positives = 403/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSL VALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLLVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFP+HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPDHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|4ICD| Phosphorylated Isocitrate Dehydrogenase (E.C.1.1.1.42)
Length = 414
Score = 814 bits (2079), Expect = 0.0
Identities = 401/414 (96%), Positives = 402/414 (96%)
Query: 3 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 62
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK
Sbjct: 1 SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERK 60
Query: 63 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 122
ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL
Sbjct: 61 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 120
Query: 123 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 182
DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE
Sbjct: 121 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 180
Query: 183 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 242
MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK
Sbjct: 181 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 240
Query: 243 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302
DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM
Sbjct: 241 DWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 300
Query: 303 NLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362
NLNGDYISDALAAQV D+CALFEATHGTAPKYAGQDKVNPGSIILSAEM
Sbjct: 301 NLNGDYISDALAAQVGGIGIAPGANIGDQCALFEATHGTAPKYAGQDKVNPGSIILSAEM 360
Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 414
pdb|1GRO| Oxidoreductase, Nadp, Phosphorylation, Glyoxylate Bypass Mol_id:
1; Molecule: Isocitrate Dehydrogenase; Chain: Null; Ec:
1.1.1.42; Engineered: Yes; Mutation: S113e, N115l
Length = 416
Score = 813 bits (2076), Expect = 0.0
Identities = 401/416 (96%), Positives = 402/416 (96%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR L VALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELLVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFP+HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPDHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
pdb|1ISO| Isocitrate Dehydrogenase: Structure Of An Engineered Nadp+ -->
Nad+ Specificity-Reversal Mutant
Length = 416
Score = 798 bits (2038), Expect = 0.0
Identities = 397/416 (95%), Positives = 397/416 (95%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE
Sbjct: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMGVKKIRFPEHCGIGIKP SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPMSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
CMNLNGDYISDALAAQV DE ALFEATHGTAP AGQDK NPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEYALFEATHGTAPDIAGQDKANPGSIILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGWTEAADLIVKGMEGAINAKTVT DFE LMDGAKLLKCSEFGDAIIENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTKDFESLMDGAKLLKCSEFGDAIIENM 416
gb|AAC45887.1| (AF017587) isocitrate dehydrogenase [Escherichia coli]
Length = 404
Score = 796 bits (2034), Expect = 0.0
Identities = 392/404 (97%), Positives = 392/404 (97%)
Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70
GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT
Sbjct: 1 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 60
Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130
GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP
Sbjct: 61 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 120
Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190
VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF
Sbjct: 121 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 180
Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250
PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR
Sbjct: 181 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 240
Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS
Sbjct: 241 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 300
Query: 311 DALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370
DALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT
Sbjct: 301 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 360
Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414
EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE
Sbjct: 361 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 404
gb|AAC45891.1| (AF017591) isocitrate dehydrogenase [Escherichia coli]
>gi|2618888|gb|AAC45893.1| (AF017593) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618890|gb|AAC45894.1| (AF017594) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618892|gb|AAC45895.1| (AF017595) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618894|gb|AAC45896.1| (AF017596) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618904|gb|AAC45901.1| (AF017601) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618906|gb|AAC45902.1| (AF017602) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618908|gb|AAC45903.1| (AF017603) isocitrate
dehydrogenase [Escherichia coli]
Length = 404
Score = 793 bits (2026), Expect = 0.0
Identities = 390/404 (96%), Positives = 392/404 (96%)
Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70
GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT
Sbjct: 1 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 60
Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130
GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP
Sbjct: 61 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 120
Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190
VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF
Sbjct: 121 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 180
Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250
PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR
Sbjct: 181 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 240
Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS
Sbjct: 241 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 300
Query: 311 DALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370
DALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT
Sbjct: 301 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 360
Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414
EAADLIVKGMEGAINAKTVTYDFERLM+GAKLLKCSEFGDAII+
Sbjct: 361 EAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEFGDAIIK 404
gb|AAC45888.1| (AF017588) isocitrate dehydrogenase [Escherichia coli]
>gi|2618880|gb|AAC45889.1| (AF017589) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618882|gb|AAC45890.1| (AF017590) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618886|gb|AAC45892.1| (AF017592) isocitrate
dehydrogenase [Escherichia coli]
Length = 404
Score = 793 bits (2026), Expect = 0.0
Identities = 390/404 (96%), Positives = 392/404 (96%)
Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70
GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT
Sbjct: 1 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 60
Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130
GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP
Sbjct: 61 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 120
Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190
VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF
Sbjct: 121 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 180
Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250
PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR
Sbjct: 181 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 240
Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS
Sbjct: 241 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 300
Query: 311 DALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370
DALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT
Sbjct: 301 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 360
Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414
EAADLIVKGMEGAINAKTVTYDFERLM+GAKLLKCSEFG+AIIE
Sbjct: 361 EAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEFGEAIIE 404
gb|AAC45898.1| (AF017598) isocitrate dehydrogenase [Escherichia coli]
>gi|2618900|gb|AAC45899.1| (AF017599) isocitrate
dehydrogenase [Escherichia coli]
>gi|2618902|gb|AAC45900.1| (AF017600) isocitrate
dehydrogenase [Escherichia coli]
Length = 404
Score = 792 bits (2023), Expect = 0.0
Identities = 389/404 (96%), Positives = 392/404 (96%)
Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70
GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT
Sbjct: 1 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 60
Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130
GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP
Sbjct: 61 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 120
Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190
VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF
Sbjct: 121 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 180
Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250
PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY+LAR
Sbjct: 181 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYELAR 240
Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS
Sbjct: 241 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 300
Query: 311 DALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370
DALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT
Sbjct: 301 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 360
Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414
EAADLIVKGMEGAINAKTVTYDFERLM+GAKLLKCSEFGDAII+
Sbjct: 361 EAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEFGDAIIK 404
gb|AAC45897.1| (AF017597) isocitrate dehydrogenase [Escherichia coli]
Length = 404
Score = 790 bits (2019), Expect = 0.0
Identities = 389/404 (96%), Positives = 391/404 (96%)
Query: 11 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 70
GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT
Sbjct: 1 GKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT 60
Query: 71 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 130
GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP
Sbjct: 61 GEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP 120
Query: 131 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF 190
VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADA KVIKFLREEMGVKKIRF
Sbjct: 121 VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAGKVIKFLREEMGVKKIRF 180
Query: 191 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 250
PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR
Sbjct: 181 PEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 240
Query: 251 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 310
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS
Sbjct: 241 EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYIS 300
Query: 311 DALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 370
DALAAQV DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT
Sbjct: 301 DALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWT 360
Query: 371 EAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIE 414
EAADLIVKGMEGAINAKTVTYDFERLM+GAKLLKCSEFGDAII+
Sbjct: 361 EAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEFGDAIIK 404
gb|AAC45904.1| (AF017604) isocitrate dehydrogenase [Salmonella enterica I]
>gi|2618914|gb|AAC45906.1| (AF017606) isocitrate
dehydrogenase [Salmonella enterica VI]
>gi|2618932|gb|AAC45915.1| (AF017615) isocitrate
dehydrogenase [Salmonella enterica IIIb]
Length = 388
Score = 749 bits (1912), Expect = 0.0
Identities = 366/388 (94%), Positives = 372/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLMDGAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMDGAKLLK 388
gb|AAC45918.1| (AF017618) isocitrate dehydrogenase [Salmonella enterica V]
>gi|2618940|gb|AAC45919.1| (AF017619) isocitrate
dehydrogenase [Salmonella enterica V]
Length = 388
Score = 748 bits (1909), Expect = 0.0
Identities = 365/388 (94%), Positives = 372/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPW+K+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWMKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAC45905.1| (AF017605) isocitrate dehydrogenase [Salmonella enterica I]
>gi|2618916|gb|AAC45907.1| (AF017607) isocitrate
dehydrogenase [Salmonella enterica VI]
>gi|2618920|gb|AAC45909.1| (AF017609) isocitrate
dehydrogenase [Salmonella enterica II]
>gi|2618930|gb|AAC45914.1| (AF017614) isocitrate
dehydrogenase [Salmonella enterica IIIb]
Length = 388
Score = 747 bits (1908), Expect = 0.0
Identities = 365/388 (94%), Positives = 372/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAC45920.1| (AF017620) isocitrate dehydrogenase [Citrobacter koseri]
Length = 388
Score = 747 bits (1907), Expect = 0.0
Identities = 365/388 (94%), Positives = 373/388 (96%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFREN+EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENAEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPW+K+KNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWVKIKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAC45916.1| (AF017616) isocitrate dehydrogenase [Salmonella enterica IIIa]
>gi|2618936|gb|AAC45917.1| (AF017617) isocitrate
dehydrogenase [Salmonella enterica IIIa]
Length = 388
Score = 746 bits (1906), Expect = 0.0
Identities = 365/388 (94%), Positives = 371/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EF GE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFSGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLMDGAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMDGAKLLK 388
gb|AAC45910.1| (AF017610) isocitrate dehydrogenase [Salmonella enterica VII]
>gi|2618924|gb|AAC45911.1| (AF017611) isocitrate
dehydrogenase [Salmonella enterica VII]
Length = 388
Score = 746 bits (1905), Expect = 0.0
Identities = 364/388 (93%), Positives = 372/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGT+RLVRAAIEYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTRRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAC45912.1| (AF017612) isocitrate dehydrogenase [Salmonella enterica IV]
>gi|2618928|gb|AAC45913.1| (AF017613) isocitrate
dehydrogenase [Salmonella enterica IV]
Length = 388
Score = 745 bits (1903), Expect = 0.0
Identities = 363/388 (93%), Positives = 372/388 (95%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGT+RLVRAA+EYAI NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTRRLVRAALEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAC45908.1| (AF017608) isocitrate dehydrogenase [Salmonella enterica II]
Length = 388
Score = 744 bits (1900), Expect = 0.0
Identities = 364/388 (93%), Positives = 371/388 (94%)
Query: 17 QNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 76
QNGKLNVPENPIIP+IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ
Sbjct: 1 QNGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQ 60
Query: 77 VYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQG 136
VYGQDVWLPAETLDLIR+YRVAIKGPLTTPVGGGIRSLNVALRQELDLY+CLRPVRYYQG
Sbjct: 61 VYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQG 120
Query: 137 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 196
TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI
Sbjct: 121 TPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 180
Query: 197 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 256
GIKPCSEEGTKRLVRAAIEYAI N RDSVTLVHKGNIMKFTEGAFKDWGYQLAR+EFGGE
Sbjct: 181 GIKPCSEEGTKRLVRAAIEYAITNARDSVTLVHKGNIMKFTEGAFKDWGYQLARDEFGGE 240
Query: 257 LIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 316
LIDGGPWLK+KNPNTGKEIV+KDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ
Sbjct: 241 LIDGGPWLKIKNPNTGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQ 300
Query: 317 VXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLI 376
V DECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHM W EAADLI
Sbjct: 301 VGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMQWFEAADLI 360
Query: 377 VKGMEGAINAKTVTYDFERLMDGAKLLK 404
VKGMEGAI AKTVTYDFERLM+GAKLLK
Sbjct: 361 VKGMEGAIAAKTVTYDFERLMEGAKLLK 388
gb|AAF16735.1|AF146294_1 (AF146294) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 618 bits (1576), Expect = e-176
Identities = 299/412 (72%), Positives = 346/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+TP M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDITPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAMKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16734.1|AF146293_1 (AF146293) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 618 bits (1576), Expect = e-176
Identities = 299/412 (72%), Positives = 346/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+TP M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDITPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
sp|P41560|IDH1_VIBA1 ISOCITRATE DEHYDROGENASE [NADP] 1 (OXALOSUCCINATE DECARBOXYLASE 1)
(IDH-I) (NADP+-SPECIFIC ICDH 1) (IDP-1)
>gi|538834|pir||B49341 isocitrate dehydrogenase (NADP+)
(EC 1.1.1.42) I - Vibrio sp. (strain ABE-1)
>gi|217189|dbj|BAA03135.1| (D14047) IDH-I [Colwellia
maris]
Length = 415
Score = 617 bits (1575), Expect = e-176
Identities = 296/416 (71%), Positives = 348/416 (83%), Gaps = 1/416 (0%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
M +K+++P G KIT +GKL+VP NPIIPYIEGDGIGVDVTP MLKVV+AAV KAY G+
Sbjct: 1 MTNKIIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGD 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKI W+E+Y GEK+T++Y + WLP ETL++++EY+V+IKGPLTTPVGGG+ SLNVA+RQ
Sbjct: 61 RKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
LDLY+C RPV+++ G PSPVK P DMVIFREN+EDIYAGIE+KA S A+ VIKFL
Sbjct: 121 MLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLI 180
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EEMG IRF E+CGIGIKP S+EG++RLVR AI+YAI N++DSVTLVHKGNIMKFTEGA
Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
FKDWGY+LA EEFG L+ GGPW +KNPNTGKEI+IKDVIADA LQQ+LLRPAEY VIA
Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
+NLNGDY+SDALAAQV DE A+FEATHGTAPKYAG++KVNPGS+ILSA
Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSA 360
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGW E ADL++KGM GAI AKTVTYDFERLMD A L+ CS FGD II++M
Sbjct: 361 EMMLRHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415
gb|AAF16733.1|AF146292_1 (AF146292) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 616 bits (1572), Expect = e-175
Identities = 298/412 (72%), Positives = 345/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+TP M VVDAA EK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDITPVMKNVVDAAAEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAC68600.1| (AF069035) isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560695|gb|AAF16725.1|AF146284_1 (AF146284)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560701|gb|AAF16728.1|AF146287_1 (AF146287)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560703|gb|AAF16729.1|AF146288_1 (AF146288)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560723|gb|AAF16739.1|AF146298_1 (AF146298)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560725|gb|AAF16740.1|AF146299_1 (AF146299)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560727|gb|AAF16741.1|AF146300_1 (AF146300)
isocitrate dehydrogenase [Coxiella burnetii]
>gi|6560729|gb|AAF16742.1|AF146301_1 (AF146301)
isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 616 bits (1571), Expect = e-175
Identities = 298/412 (72%), Positives = 345/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16726.1|AF146285_1 (AF146285) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 615 bits (1568), Expect = e-175
Identities = 298/412 (72%), Positives = 345/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLVVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16738.1|AF146297_1 (AF146297) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 615 bits (1568), Expect = e-175
Identities = 297/412 (72%), Positives = 345/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP++G+KIT+ L VP+ PIIP+IEGDGIG+D+TP M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSEGEKITVNKAVLEVPDRPIIPFIEGDGIGIDITPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+F AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSASQFAKAIIKHI 426
gb|AAF16731.1|AF146290_1 (AF146290) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 615 bits (1568), Expect = e-175
Identities = 298/412 (72%), Positives = 344/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLGAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16736.1|AF146295_1 (AF146295) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 613 bits (1564), Expect = e-175
Identities = 296/412 (71%), Positives = 344/412 (82%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP++G+KIT+ L P+ PIIP+IEGDGIG+D+TP M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSEGEKITVNKAVLEAPDRPIIPFIEGDGIGIDITPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+F AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSASQFAKAIIKHI 426
gb|AAF16730.1|AF146289_1 (AF146289) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 613 bits (1564), Expect = e-175
Identities = 297/412 (72%), Positives = 344/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+ Y+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKGYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16737.1|AF146296_1 (AF146296) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 613 bits (1564), Expect = e-175
Identities = 296/412 (71%), Positives = 344/412 (82%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP++G+KIT+ L VP+ PIIP+IEGDGIG+D+TP M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSEGEKITVNKAVLEVPDRPIIPFIEGDGIGIDITPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+ YG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKAYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+F AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSASQFAKAIIKHI 426
gb|AAF16727.1|AF146286_1 (AF146286) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 610 bits (1557), Expect = e-174
Identities = 297/412 (72%), Positives = 344/412 (83%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++G EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGRKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
gb|AAF16732.1|AF146291_1 (AF146291) isocitrate dehydrogenase [Coxiella burnetii]
Length = 427
Score = 609 bits (1554), Expect = e-173
Identities = 296/412 (71%), Positives = 343/412 (82%)
Query: 5 VVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKIS 64
+ VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI
Sbjct: 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74
Query: 65 WMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDL 124
WMEIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDL
Sbjct: 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134
Query: 125 YICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMG 184
Y+CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMG
Sbjct: 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194
Query: 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW 244
VKKIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDW
Sbjct: 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254
Query: 245 GYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNL 304
GY++A +EFG + +DG PW +NP TG++I IKDVIADAFLQQILLRPAE VIA +NL
Sbjct: 255 GYEVAVKEFGAKPLDGRPWHVFENPKTGQKITIKDVIADAFLQQILLRPAECSVIATLNL 314
Query: 305 NGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML 364
NGDYISDALAA+V D LFEATHGTAPKYAGQDKVNPGS+ILSAEMML
Sbjct: 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374
Query: 365 RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
R++GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++
Sbjct: 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426
pir||E71982 isocitrate dehydrogenase - Helicobacter pylori (strain J99)
>gi|4154528|gb|AAD05607.1| (AE001442) ISOCITRATE
DEHYDROGENASE [Helicobacter pylori J99]
Length = 425
Score = 578 bits (1475), Expect = e-164
Identities = 281/416 (67%), Positives = 336/416 (80%), Gaps = 8/416 (1%)
Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
P +G++IT+++GKL+VP PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 11 PKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
Query: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 71 VFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
E+ V+KIRFPE G+GIKP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 190 NELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
F WGY LA++EF ++ID GPW +KNP TGKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
MNLNGDYISDALAA V D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
sp|P56063|IDH_HELPY ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|7431237|pir||C64523 isocitrate dehydrogenase (NADP+)
(EC 1.1.1.42) - Helicobacter pylori (strain 26695)
>gi|2313104|gb|AAD07098.1| (AE000525) isocitrate
dehydrogenase (icd) [Helicobacter pylori 26695]
Length = 425
Score = 577 bits (1471), Expect = e-164
Identities = 280/416 (67%), Positives = 335/416 (80%), Gaps = 8/416 (1%)
Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
Query: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
Query: 301 CMNLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
MNLNGDYISDALAA V D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
Query: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
gb|AAB39334.1| (U55996) isocitrate dehydrogenase [Thermus aquaticus]
Length = 426
Score = 557 bits (1421), Expect = e-158
Identities = 277/421 (65%), Positives = 329/421 (77%), Gaps = 8/421 (1%)
Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63
++ +P +G+KIT+Q G L VP+ PII +IEGDG G D+ A V+DAAV KAY G+R+I
Sbjct: 5 RIQIPQEGEKITIQEGVLKVPDQPIIGFIEGDGTGPDIWRAAQPVLDAAVAKAYGGQRRI 64
Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD 123
W+E+Y GEK+ QVYG+ +WLP ETL+ IREY VAIKGPLTTPVGGGIRS+NVALRQELD
Sbjct: 65 VWVELYAGEKANQVYGEPIWLPEETLEFIREYLVAIKGPLTTPVGGGIRSINVALRQELD 124
Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183
LY C+RPVR++QG PSPVKHPEL +MVIFREN+EDIYAGIEW A S + +KV+ FL+ E
Sbjct: 125 LYACVRPVRWFQGVPSPVKHPELVNMVIFRENTEDIYAGIEWPAGSEEVKKVLDFLKREF 184
Query: 184 --GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 241
KIRFPE G+G+KP S+EGT+RLV AAIEYAI D SVTLVHKGNIMKFTEGAF
Sbjct: 185 PKAYAKIRFPETSGLGLKPISKEGTERLVEAAIEYAIKEDLPSVTLVHKGNIMKFTEGAF 244
Query: 242 KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIAC 301
++WGY LARE++G +DGGPW +KNP TG+EIVIKD+IAD FLQQILLRP EY VIA
Sbjct: 245 REWGYALAREKYGATPLDGGPWHVLKNPRTGREIVIKDMIADNFLQQILLRPDEYSVIAT 304
Query: 302 MNLNGDYISDALAAQVXXXXXXXXXXXXDEC--ALFEATHGTAPKYAGQDKVNPGSIILS 359
MNLNGDYISDALAAQV + A+FEATHGTAPKYAGQDKVNP S+ILS
Sbjct: 305 MNLNGDYISDALAAQVGGIGIAPGANINYKTGHAVFEATHGTAPKYAGQDKVNPSSVILS 364
Query: 360 AEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLM----DGAKLLKCSEFGDAIIEN 415
EMMLR++GW EAADLI++ ME I+ VTYDF RL+ A LLK SEFG A+I++
Sbjct: 365 GEMMLRYLGWNEAADLIIRAMERTISKGLVTYDFHRLLVAEGKPATLLKTSEFGQALIQH 424
Query: 416 M 416
M
Sbjct: 425 M 425
pir||D75382 isocitrate dehydrogenase - Deinococcus radiodurans (strain R1)
>gi|6459303|gb|AAF11104.1|AE001998_1 (AE001998)
isocitrate dehydrogenase [Deinococcus radiodurans]
Length = 430
Score = 552 bits (1408), Expect = e-156
Identities = 276/418 (66%), Positives = 318/418 (76%), Gaps = 7/418 (1%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
M + VP QG+KIT+QNGKL VP PIIP++EGDG G D+ A ++V DAAVEKAY E
Sbjct: 15 MSKHIKVPEQGEKITMQNGKLTVPNRPIIPFVEGDGTGPDIWAASVRVFDAAVEKAYGSE 74
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RK+ WME+Y GEKS +VYG + WLP ETL R+Y IKGPLTTPVG GIRS+NVALRQ
Sbjct: 75 RKLEWMEVYAGEKSLEVYGANEWLPQETLTAFRDYLFGIKGPLTTPVGTGIRSINVALRQ 134
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
ELDLY C+RPV+Y+ G PSPVK PE DMVIFREN+EDIYAGIEWKA + +AEKV FL
Sbjct: 135 ELDLYACVRPVQYFNGVPSPVKRPEDIDMVIFRENTEDIYAGIEWKAGTDEAEKVRGFLM 194
Query: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
EM V KIRFP+ G+KP S+EGT+RLVRAAIEYAI N R SV+LVHKGNIMKFTEG
Sbjct: 195 REMNVTKIRFPDTSSFGVKPVSKEGTERLVRAAIEYAIENGRKSVSLVHKGNIMKFTEGG 254
Query: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
F+DWGY+LA+ EFG IDGGPW ++ N IVIKDVIAD FLQQILLRP EYDVIA
Sbjct: 255 FRDWGYELAKREFGAVEIDGGPWCQLPN-----GIVIKDVIADNFLQQILLRPTEYDVIA 309
Query: 301 CMNLNGDYISDALAAQVXXXXXX--XXXXXXDECALFEATHGTAPKYAGQDKVNPGSIIL 358
+NLNGDYISDALAAQV A+FEATHGTAPKYAG++ +NP S+IL
Sbjct: 310 TLNLNGDYISDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGKNVINPSSVIL 369
Query: 359 SAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
S EMMLR+MGWTEAADLI+KG++ I + VTYDF R MD A +K SEF D IIENM
Sbjct: 370 SGEMMLRYMGWTEAADLILKGLDATIQQRVVTYDFARGMDDATEVKTSEFADKIIENM 427
sp|P39126|IDH_BACSU ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|2117469|pir||I40382 isocitrate dehydrogenase (NADP+)
(EC 1.1.1.42) - Bacillus subtilis
>gi|487434|gb|AAA96342.1| (U05257) isocitrate
dehydrogenase [Bacillus subtilis]
>gi|2293268|gb|AAC00346.1| (AF008220) isocitrate
dehydrogenase [Bacillus subtilis]
>gi|2635378|emb|CAB14873.1| (Z99118) isocitrate
dehydrogenase [Bacillus subtilis]
Length = 423
Score = 538 bits (1370), Expect = e-152
Identities = 271/423 (64%), Positives = 321/423 (75%), Gaps = 17/423 (4%)
Query: 9 AQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEI 68
AQG+KIT+ NG LNVP NPIIP+IEGDG G D+ A KV++AAVEKAYKGE+KI+W E+
Sbjct: 2 AQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEV 61
Query: 69 YTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICL 128
Y GEK+ G+ WLPAETLD+IREY +AIKGPLTTPVGGGIRSLNVALRQELDL++CL
Sbjct: 62 YAGEKAYNKTGE--WLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCL 119
Query: 129 RPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKI 188
RPVRY+ G PSPVK PE TDMVIFREN+EDIYAGIE+ S + +K+I FL+ E+ V KI
Sbjct: 120 RPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKI 179
Query: 189 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 248
RFPE GIGIKP SEEGT RLVRAAI+YAI + R SVTLVHKGNIMKFTEGAFK+WGY+L
Sbjct: 180 RFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYEL 239
Query: 249 AREEFGGELIDGGPWLKV-------------KNPNTGKEIVIKDVIADAFLQQILLRPAE 295
A +E+G ++ + ++ +I+IKD IAD FLQQIL RP E
Sbjct: 240 AEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNE 299
Query: 296 YDVIACMNLNGDYISDALAAQVXXXXXXXXXXXXDEC--ALFEATHGTAPKYAGQDKVNP 353
+DV+A MNLNGDYISDALAAQV E A+FEATHGTAPKYAG DKVNP
Sbjct: 300 FDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNP 359
Query: 354 GSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413
S+ILS ++L H+GW EAADL++K ME I +K VTYDF RLMDGA +KCSEFG+ +I
Sbjct: 360 SSVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGEELI 419
Query: 414 ENM 416
+NM
Sbjct: 420 KNM 422
emb|CAA73794.1| (Y13358) isocitrate dehyrogenase [Bacillus israeli]
Length = 425
Score = 534 bits (1362), Expect = e-151
Identities = 272/427 (63%), Positives = 325/427 (75%), Gaps = 19/427 (4%)
Query: 6 VVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISW 65
++ A+G+KIT+ NG LNVP +PIIP+IEGDG G D+ A KV++AAVEKAY GE+KI W
Sbjct: 1 MIVAEGQKITMTNGTLNVPNDPIIPFIEGDGTGPDIWRAASKVLEAAVEKAYNGEKKIVW 60
Query: 66 MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLY 125
E+ GEK+ + G+ WLP ETLD+IREY +AIKGPLTTPVGGGIRSLNVALRQELDL+
Sbjct: 61 KEVLAGEKAFKETGE--WLPQETLDVIREYMIAIKGPLTTPVGGGIRSLNVALRQELDLF 118
Query: 126 ICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGV 185
+CLRPVRY+ G PSPVK P+ TDMVIFREN+EDIYAGIE+ + + +KVI+FL++E+GV
Sbjct: 119 VCLRPVRYFNGVPSPVKRPQDTDMVIFRENTEDIYAGIEYAKGTEEVKKVIEFLQKELGV 178
Query: 186 KKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWG 245
KIRFPE GIGIKP SEEGTKRLVRAAI YAI + R SVTLVHKGNIMKFTEGAFK+WG
Sbjct: 179 NKIRFPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWG 238
Query: 246 YQLAREEFGGELIDGGPWLKVKNPNTGKE--------------IVIKDVIADAFLQQILL 291
Y+LA +EFG ++ + ++ GKE I+IKD IAD FLQQIL
Sbjct: 239 YELAEQEFGDKVFTWAEYDRIVE-KEGKEAANKAQEEAEKAGKIIIKDAIADIFLQQILT 297
Query: 292 RPAEYDVIACMNLNGDYISDALAAQVXXXXXXXXXXXXDEC--ALFEATHGTAPKYAGQD 349
RP E+DV+A MNLNGDYISDALAAQV E A+FEATHGTAPKYAG D
Sbjct: 298 RPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLD 357
Query: 350 KVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFG 409
KVNP S+ILS +ML H+GW EAADLI++ ME I +K VTYDF RLMDGA +KCSEFG
Sbjct: 358 KVNPSSVILSGVLMLEHLGWKEAADLIIQAMEKTIASKVVTYDFARLMDGATEVKCSEFG 417
Query: 410 DAIIENM 416
+ +I+NM
Sbjct: 418 NELIKNM 424
sp|P50214|IDH_ANASP ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|1075642|pir||A55591 isocitrate dehydrogenase (NADP+)
(EC 1.1.1.42) - Anabaena sp. (strain PCC 7120)
>gi|467706|emb|CAA54734.1| (X77654) isocitrate
dehydrogenase (NADP+) [Anabaena sp.]
Length = 473
Score = 451 bits (1149), Expect = e-126
Identities = 241/473 (50%), Positives = 306/473 (63%), Gaps = 60/473 (12%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
M +K+ P G+KIT +NG+ VP+NPIIP+I GDG G+D+ PA KV+DAAV KAY+G+
Sbjct: 1 MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGK 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKISW ++Y G+++ +YG +LP +TL IREY VAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKISWFKVYAGDEACDLYGTYQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
DLY C+RP RYY GTPSP K+PE D++++REN+EDIY GIEWK S +++I L
Sbjct: 121 IFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYLGIEWKQGSEIGDRLISILN 180
Query: 181 EEM-------GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA--NDRDSVTLVHKG 231
+E+ G K+I P GIGIKP S+ G++RLVR AI++A+ D+ VTLVHKG
Sbjct: 181 KELIPATPEHGKKQI--PLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKG 238
Query: 232 NIMKFTEGAFKDWGYQLAREEFGGELI-DGGPWL---KVKNPNTGKE------------- 274
NIMK+TEGAF+DWGY+LA EF E + + W+ K KNPN E
Sbjct: 239 NIMKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDAL 298
Query: 275 -------------------------------IVIKDVIADAFLQQILLRPAEYDVIACMN 303
+++ D IAD+ QQI RP EY ++A MN
Sbjct: 299 TPEKKAQIVKEVETVLNSIWESHGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMN 358
Query: 304 LNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363
LNGDY+SDA AA V D CA+FEATHGTAPK+AG D++NPGS+ILS MM
Sbjct: 359 LNGDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKHAGLDRINPGSVILSGVMM 418
Query: 364 LRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMD-GAKLLKCSEFGDAIIEN 415
L +MGW EAADLI KG+ AI VTYD RL++ + LKCSEF DAII++
Sbjct: 419 LEYMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKH 471
pir||G69330 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) - Archaeoglobus
fulgidus >gi|2649970|gb|AAB90591.1| (AE001060)
isocitrate dehydrogenase, NADP (icd) [Archaeoglobus
fulgidus] >gi|3043374|emb|CAB09535.1| (Z96105)
isocitrate dehydrogenase [Archaeoglobus fulgidus]
Length = 412
Score = 434 bits (1103), Expect = e-120
Identities = 224/414 (54%), Positives = 287/414 (69%), Gaps = 10/414 (2%)
Query: 4 KVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63
KV P G+KI +NGKL VP+NPIIPY EGDGIG DV PA ++V+DAA +K K ++
Sbjct: 5 KVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGK---EV 61
Query: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD 123
W ++Y GE + ++YG +LP +TL+ I+E+RVA+KGPLTTPVGGG RSLNV +RQ LD
Sbjct: 62 VWFQVYAGEDAYKLYGN--YLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLD 119
Query: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183
LY +RPV Y +G PSP+KHPE + VIFREN+ED+YAGIEW S +A K+I+FL+ E
Sbjct: 120 LYANVRPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEF 179
Query: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243
GV E GIGIKP SE TKRLVR AI YAI N+R SVTLVHKGNIMK+TEGAF+D
Sbjct: 180 GV---TIREDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRD 236
Query: 244 WGYQLAREEFGGELI-DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACM 302
WGY++A++EFG I + W K +IV+KD IAD QQIL R EYDVIA
Sbjct: 237 WGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALP 296
Query: 303 NLNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEM 362
NLNGDY+SDA AA + D +FE HG+APKYAGQ+KVNP + IL+ +
Sbjct: 297 NLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFEPVHGSAPKYAGQNKVNPTAEILTGAL 356
Query: 363 MLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
M ++GW +A+++I K +E I++ VTYD R M G K + EF +A++EN+
Sbjct: 357 MFEYIGWKDASEMIKKAVEMTISSGIVTYDIHRHMGGTK-VGTREFAEAVVENL 409
sp|Q59940|IDH_STRMU ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|1421814|gb|AAC44826.1| (U62799) isocitrate
dehydrogenase [Streptococcus mutans]
Length = 393
Score = 431 bits (1097), Expect = e-120
Identities = 214/404 (52%), Positives = 284/404 (69%), Gaps = 18/404 (4%)
Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71
+K++ + GKL VP+ P+IPYIEGDG+G D+ V D A+ K Y G +++ W E+ G
Sbjct: 3 EKVSFEEGKLQVPDKPVIPYIEGDGVGQDIWKNAQIVFDKAIAKVYGGHKQVIWREVLAG 62
Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131
+K+ + G WLP ETL++I+ + +AIKGPL TPVGGGIRSLNVALRQELDL+ C+RPV
Sbjct: 63 KKAYKETGN--WLPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPV 120
Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191
RY++G PSP+KHPE T + IFREN+EDIYAGIEW A +A+ +KVI FL+++M VKKIRFP
Sbjct: 121 RYFKGVPSPLKHPEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFP 180
Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251
+ IGIKP S EG++RL+RAAIEYA+AN+ VTLVHKGNI KFTEG F+ WGY+LA+
Sbjct: 181 KSSSIGIKPISIEGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKR 240
Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311
E+ EL G ++V+ D+IAD FLQQILL+P +DV+A NLNGDY SD
Sbjct: 241 EYAAELASG-------------QLVVDDIIADNFLQQILLKPERFDVVALTNLNGDYASD 287
Query: 312 ALAAQVXXXXXXXXXXXXDEC--ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369
ALAAQV + A+FEATHGTAP AGQD NP S++LS M+ ++GW
Sbjct: 288 ALAAQVGGIGISPGANINYQTGHAIFEATHGTAPDIAGQDLANPSSVLLSGCMLFDYIGW 347
Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413
++ +DLI+K +E AI VT DF + + G + L +F + ++
Sbjct: 348 SKVSDLIMKAVEKAIANGQVTIDFAKEL-GVEALTTCQFSEVLL 390
pir||S74684 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) - Synechocystis sp.
(strain PCC 6803) >gi|1651909|dbj|BAA16835.1| (D90901)
isocitrate dehydrogenase (NADP+) [Synechocystis sp.]
Length = 475
Score = 427 bits (1086), Expect = e-118
Identities = 235/474 (49%), Positives = 294/474 (61%), Gaps = 61/474 (12%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY GE
Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGE 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
RKI+W ++Y G+++ ++YG +LP +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 RKINWFKVYAGDEACELYGTYQYLPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L
Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180
Query: 181 EE-------MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA--IANDRDSVTLVHKG 231
+E +G K+IR GIGIKP S+ G++RLVR AI +A + + VTLVHKG
Sbjct: 181 DELIPTTPALGKKQIRLDS--GIGIKPISKTGSQRLVRRAILHALRLPKAKQMVTLVHKG 238
Query: 232 NIMKFTEGAFKDWGYQLAREEFGGE--------------------------LIDGG---- 261
NIMKFTEGAF+DWGY+LA EF E +ID G
Sbjct: 239 NIMKFTEGAFRDWGYELATTEFRAECVTERESWILGNKESNPDLTIEANAHMIDPGYDTL 298
Query: 262 ------------------PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303
W N +++++ D IAD+ QQI RP EY ++A MN
Sbjct: 299 TEEKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMN 358
Query: 304 LNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363
LNGDY+SDA AA V D A+FEATHGTAPK+AG D++NPGS+ILS MM
Sbjct: 359 LNGDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMM 418
Query: 364 LRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIEN 415
L MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ +
Sbjct: 419 LEFMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472
sp|Q59985|IDH_STRSL ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|1280403|gb|AAA98355.1| (L14780) isocitrate
dehydrogenase [Streptococcus salivarius]
Length = 391
Score = 421 bits (1072), Expect = e-117
Identities = 220/407 (54%), Positives = 277/407 (68%), Gaps = 20/407 (4%)
Query: 12 KKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTG 71
+KI ++NG+L V + PIIP+IEGDG+G D+ + D AVE AY+G+R I W E+ G
Sbjct: 3 EKIVMKNGQLQVSDRPIIPFIEGDGVGHDIWKNAQAIFDKAVEVAYEGKRHIEWQELLAG 62
Query: 72 EKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPV 131
+K+ G+ WLP ETL+ IRE VAIKGPL TPVGGGIRSLNVALRQELDLY C+RPV
Sbjct: 63 KKAYDKTGE--WLPKETLEAIRESLVAIKGPLETPVGGGIRSLNVALRQELDLYACVRPV 120
Query: 132 RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFP 191
RY+ G SP+K PE T++ IFREN+EDIYAGIEW+A +AD ++VI+FL+ EM V KIRFP
Sbjct: 121 RYFDGVASPLKEPEKTNITIFRENTEDIYAGIEWEAGTADVKRVIEFLQTEMNVNKIRFP 180
Query: 192 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 251
E IGIKP S EG+KRL+R+AI+YA+ N+ VTLVHKGNI KFTEG F+ WGY++A+E
Sbjct: 181 ESSSIGIKPISIEGSKRLIRSAIDYALKNNLKKVTLVHKGNIQKFTEGGFRKWGYEVAQE 240
Query: 252 EFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISD 311
++ EL+ G + I D+IAD FLQQILL P ++DV+A NLNGDY SD
Sbjct: 241 DYKEELLAG-------------RLEINDIIADNFLQQILLNPEKFDVVALTNLNGDYASD 287
Query: 312 ALAAQVXXXXXXXXXXXXDEC--ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGW 369
ALAAQV + A+FEATHGTAP A QDK NP S++LS M+L ++GW
Sbjct: 288 ALAAQVGGIGISPGANINYQTGHAIFEATHGTAPDIADQDKANPCSVLLSGCMLLDYIGW 347
Query: 370 TEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
TEAA LI +E A T D L G + S F + I+ M
Sbjct: 348 TEAAQLITSAIEKTFKADIFTAD---LAFGKQAYSTSAFSNQILSIM 391
sp|P80046|IDH_SYNY3 ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE)
(IDH) (NADP+-SPECIFIC ICDH) (IDP)
>gi|1478267|emb|CAA58549.1| (X83563) isocitrate
dehydrogenase (NADP+) [Synechocystis sp.]
Length = 475
Score = 416 bits (1058), Expect = e-115
Identities = 230/474 (48%), Positives = 289/474 (60%), Gaps = 61/474 (12%)
Query: 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGE 60
M K+ P+ G KIT GK VP +PIIPYI GDG GVD+ PA V++AA+ KAY G
Sbjct: 1 MYEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGR 60
Query: 61 RKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
+I+W ++Y G+++ ++YG P +TL I+EY VAIKGPLTTPVGGGIRSLNVALRQ
Sbjct: 61 EEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
DLY C+RP RYY GTPSP K PE D++++REN+EDIY GIEW + A+K+I +L
Sbjct: 121 IFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLN 180
Query: 181 EE-------MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA--IANDRDSVTLVHKG 231
+E +G K+IR GIGIKP S+ G++RLVR AI +A + + VTLVHKG
Sbjct: 181 DELIPTTPALGKKQIRLDS--GIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKG 238
Query: 232 NIMKFTEGAFKDWGYQLAREEFGGE--------------------------LIDGG---- 261
NIMKFTEG F+DWGY+LA EF E +ID G
Sbjct: 239 NIMKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTL 298
Query: 262 ------------------PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMN 303
W N +++++ D IAD+ QQI RP EY ++A MN
Sbjct: 299 TEEKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMN 358
Query: 304 LNGDYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMM 363
LNGDY+SDA AA V D A+FEATHGTAPK+AG D++NPGS+ILS MM
Sbjct: 359 LNGDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMM 418
Query: 364 LRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA--KLLKCSEFGDAIIEN 415
L MGW EAADLI KG+ AI + VTYD RLM+ K LKCSEF AI+ +
Sbjct: 419 LEFMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472
pir||A72658 probable isocitrate dehydrogenase APE0689 - Aeropyrum pernix
(strain K1) >gi|5104350|dbj|BAA79665.1| (AP000060) 435aa
long hypothetical isocitrate dehydrogenase [Aeropyrum
pernix]
Length = 435
Score = 358 bits (909), Expect = 6e-98
Identities = 190/408 (46%), Positives = 256/408 (62%), Gaps = 8/408 (1%)
Query: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
P G + G L VP+NP++ +I GDG+G +V + LKVVDAAV+K Y G R+I W E
Sbjct: 17 PPGGSLVEYSGGSLRVPDNPVVAFIRGDGVGPEVVESALKVVDAAVKKVYGGSRRIVWWE 76
Query: 68 IYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYIC 127
+ G + + G+ LP TL+ IR RVA+KGPL TPVG G RSLNVA+RQ LDLY
Sbjct: 77 LLAGHLAREKCGE--LLPKATLEGIRLARVALKGPLETPVGTGYRSLNVAIRQALDLYAN 134
Query: 128 LRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK 187
+RPVRYY G P+P K+ + DMVIFREN+ED+YAGIEW DS +A ++ +FL EE G+
Sbjct: 135 IRPVRYY-GQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGIS- 192
Query: 188 IRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247
E GIG+KP S T+RL+ A+E+A+ N VT++HKGNIMK+TEGAF W Y+
Sbjct: 193 --IREDAGIGVKPISRFATRRLMERALEWALRNGNTVVTIMHKGNIMKYTEGAFMRWAYE 250
Query: 248 LAREEFGGELI-DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306
+A E+F ++ + K +I++ D IAD LQQI+ RP +Y VI NLNG
Sbjct: 251 VALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNG 310
Query: 307 DYISDALAAQVXXXXXXXXXXXXDECALFEATHGTAPKYAGQDKVNPGSIILSAEMML-R 365
DYISDA +A V D A+ E HGTAPKYAG+D +NP + ILSA +++
Sbjct: 311 DYISDAASALVGGIGMAAGMNMGDGIAVAEPVHGTAPKYAGKDLINPSAEILSASLLIGE 370
Query: 366 HMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAII 413
MGW E ++ + A+ +K VT D R M G + L+ SE+ + +I
Sbjct: 371 FMGWREVKSIVEYAIRKAVQSKKVTQDLARHMPGVQPLRTSEYTETLI 418
Database: nr
Posted date: Apr 17, 2000 9:40 PM
Number of letters in database: 155,073,766
Number of sequences in database: 494,619
Lambda K H
0.318 0.138 0.406
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 126966352
Number of Sequences: 494619
Number of extensions: 5441526
Number of successful extensions: 11527
Number of sequences better than 10.0: 253
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 10762
Number of HSP's gapped (non-prelim): 342
length of query: 416
length of database: 155,073,766
effective HSP length: 55
effective length of query: 361
effective length of database: 127,869,721
effective search space: 46160969281
effective search space used: 46160969281
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 72 (32.5 bits)
