Effect of B vitamins on Homocysteine induced neural tube defects in Xenopus Laevis Embryos

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/wD//////wD///////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////wMAAAAAAA== ------=_NextPart_01C51984.B7025CD0 Content-Location: file:///C:/272B5D12/Citrinfinalprojectposter_files/master02.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"

‹header›

‹date/time›=

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------=_NextPart_01C51984.B7025CD0 Content-Location: file:///C:/272B5D12/Citrinfinalprojectposter_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C51984.B7025CD0 Content-Location: file:///C:/272B5D12/Citrinfinalprojectposter_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Effect of B vitamins on Homocysteine induced neural tube defects in Xenopus Laevis Embryos

Effect of B vitamins on Homocysteine induced neural tube defects
in Xenopus laevis= Embryos

Intro= duction:

•Folic Acid (FA) consumption by pregnant women prevents neur= al tube defects (NTDs).<= span style=3D'font-family:Helvetica;font-size:25%;position:relative;top:-.45em; mso-text-raise:30%'>1

•<= /span>FA is a B vitamin.2

•FA protects against Homocysteine (Hcys) induced (NTDs) in chick embryos.2

Metho= ds:

Part 1: Find teratogenic Hcys dose:

•Treat st.8 embryos with 100 mM, 50 mM, 5 mM and 1 mM = concentrations of Hcys. (n=3D12)

•<= /span>Fix embryos after 48 hours.&= #13;

•Observe NTDs by measuring dorsal structures of embryos= .

•<= /span>Decided to use 100mM 50mM

Part 2: Determine if FA or B12 rescues Hcys treated tadpoles.

•9 treatments: 3 concentrations Hcys(100 mM, 50 mM, 0 mM) x = B12 or FA or Steinberg’= ;s. (n=3D12)

Max L. Citrin, Davidson College, 2004

Tadpole spinal chord curv= ature increases with increasing concentrations of Hcys. Each line represents a lateral spinal tracing of a tadpole.= The percent of tadpoles in a grou= p with a 90 degree curve or gr= eater is listed in the upper right of each box. B12 and FA treatments appear to decrease the= Hcys induced curvature in the 100mM treatment.

0 mM

50mM

100mM

Concentration of Hcys

B12

Control

Treatment

Mean Tail Length (+SD) decreases with increasing Hcys concentration. Tail length was consistent regardless of concurrent tre= atment with FA and B12.

Mean (+SD) distance from dorsal fin inception to dorsal fin peak appears to decrease as Hcys concentration increases. B12 and FA&nbs= p; do not alter this effect of Hcys.

Images were analyzed in image J to determine: dorsal curvature (black); tail length(blue); distance from inception of dorsal fin to peak of dorsal= fin (green)

Conclusions:

<= span style=3D'font-family:Helvetica;font-size:50%'>•Hcys induces NTD’s in = st. 8 Xenopus embryos •<= /span>Neither FA nor B12 rescued t= he majority of Hcys induced NTDs. •Higher concentrations of B12 and FA could be = tested in the future. Repeat experiments should = focus on the relative effect= s of B12 and FA on spinal curvature.

Res= ults:

5 mm

Examples of Hcys effect on tadpoles included: curved spine (black); shortened tail (blue); shorter distance to peak of dorsal f= in (red)

1 mm

<= /div>

References:

1Zlotogora J., Amitai = Y, Kaluski DN, Leventhal A. (2002). Surveillance = of neural tube defects in Israel.&nb= sp; Isr Med Assoc J. 4:1111-4.

2Rosenquist TH, Ratashak SA, Selhub J. (1996). Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid. 93:15227–32.

67%

16%

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