Class Reading Assignments Spring 2009
Bio111: Molecules Genes and Cells, Prof Bernd

Assigned pages are Study Guide pages and include the reading and study questions that are to be prepared before that day's class. Readings will be adjusted if needed (written assignment due days and times will not change, only content covered in those assignments).

UNIT I

Date Topic Study Guide pgs

Jan 13
T

Introduction to course: What is a Cell? The Inner Life of a CellUnit 1: Stress Response and Sugar release (Cellular Communication)
additional animated resources
Intro to polymers and basic molecule types
(Lab begins this week. The Lab manual is 'behind' the study guide.)

1- image on3
R

Sugar release: Second messengers and signaling cascades. New molecule type--nucleic acids

4- ?s on 10

Jan 20
T

Stopping the cascade: reversing and removing to get back to 'normal'
Using the sugar
Your heart pounds-- Channels, Pumps and Muscle contractions part I

10-20

R

Your heart pounds-- Muscle contractions part II
Myosin heads are dancin' song: http://www.biosongs.com/br3lyrics/6.html

Legs don't fail me now--intro to neurons and synapses and membrane potentials

 catch up and continue through 22
Jan 27 Legs don't fail me now-- action potentials
Turning action potential into muscle info---Synaptic Vesicle release		 23-29
R

How does an egg know when it is fertilized? Another way of using 2nd messengers Fast and slow blocks--what are they and why do we need them?

 29-35
Feb 3

Fast and slow blocks--what are they and why do we need them?
Very similar--but different: Other signaling pathways.

35-38
R Wrap up and Q and A for review
Review1 will be emailed to you by noon Friday and will cover pages 1-38 of Study Guide and first 4 weeks of Lab.
  
Feb 10 Review1 is due before 9:45am Tuesday the 10th. It must be slid under my office door and signed in. You must begin the review by 10pm Monday night. See syllabus for details of late policy. (no other class this day)  

UNIT II

Date Topic S G pgs

Feb 11
R

 Unit II: Genetics    Inherited diseases: Sickle Cell, Cystic Fibrosis, Huntingtons
Mitosis and Meiosis review and compare the stages; Making and interpreting pedigrees,
Meiosis all rapped up http://www.biosongs.com/11.htm
Inherited diseases: How do we talk about them?Traits vs alleles, genotypes vs. phenotypes, learning the terms and how to use them		 39-45
Feb 17

Inherited diseases: DNA and an overview of gene expression (transcription and translation)
Cell cycle rap http://www.biosongs.com/10.htm

 45-50
1st set of ?
R

Inherited diseases: The SRY example and the importance of mutations in evolution and the prevalence of silent mutation.
Inherited diseases: Gene expression and revising the common definition of mutation

 50-54

Feb 24

Finish up 50-54
Mitosis/meoisis/pedigree quiz available at the end of class. Covers through pg 48

  
R


Mitosis/meoisis due before beginning of class.

 
Mar 3

Spring Break

  
Mar 10

Sickle Cell --Difference in a gene leading to different protein folding. The molecular (protein) and genetic (DNA) differences between wildtype and SC hemoglobin. .

Inherited diseases: Intro to Cystic Fibrosis How do you begin searching when there is no 'obvious' protein? ReIntroduction to Mendels Laws
How to we find a gene in all that DNA: 'Classic' Linkage analysis / RFLPs and VNTRs

55-68
R Inherited diseases: Cystic Fibrosis -- A chromosome is 'big'. How do we get closer: recombination Inherited diseases: Cystic Fibrosis-- Positional Cloning and Genomic approaches
Do, and check, questions found at this link
http://www.bio.davidson.edu/Courses/Bio111/campbell/CF_RFLP/RFLP_CF.html
 68-76

Mar 17

 Inherited diseases: Cystic Fibrosis-- What is the CF mutation? What is the problem and how can we tell?
Review 2 will be emailed to you by 5pm today and will cover pages SG 39-82 and LM55-75
Review 2 is due before 5pm on Friday March 20th It must be slid under my office door and signed in. You must begin the review by 10pm Thursday night. See syllabus for details of late policy. 		77-82

UNIT III

Date Topic Study Guide pgs
Mar 19

Unit III: Bioenergetics: Poison Pot and an Introduction to energy
Poison Pot: Light, Pigments and Energy
How and where do molecules store energy?
Listen to the kinetic and potential energy song http://www.acme.com/jef/science_songs/kinetic_potential-32.mp3

 89-95
Mar 24

Review of basic thermodynamic terms and definitions
Poison Pot: The Light Reactions and harvesting energy from photons
webquiz available through Blackboard
Amino Acid/ Peptide webquiz due by 5pm Friday March 27th

 92-99
R Poison Pot: Calvin-Benson Cycle and making carbon skeletons
 99-103
Mar 31 Cyanide and poison grapes: Only plants photosynthesize-- all cells metabolize glucose, how does that work? Cellular respiration (glycolysis/ Citric Acid Cycle and Oxidative Phosphorylation)
 103-107

R

 Cyanide and poison grapes: Citric Acid Cycle and Oxidative Phosphorylation
 		107-112
Apr7 Why health officials require vaccinations during floods and
Carbon is not enough-- need nitrogen, but how?

112-116
R Wrap up and Q&A session .
Review 3 will be emailed to you by noon today and will cover pages SG 88-116 and LM76-84
  
Apr 14 Easter Break
  

R

 Review 3 DUE At my OFFICE Before 8:30 am on Friday April 17th (begin before 10pm Thursday)
no class on Thursday the 16th		  

UNIT IV

Date Topic Study Guide pgs
Apr21 Unit IV: Other Interesting Topics:Epidemiology, Communicable diseases including HIV  (note we are skipping a topic) 131-134

R

 HIV/AIDs: retroviruses and brief introduction to immunology
 134-138

Apr 28

HIV/AIDs: attempts at treatment
Final Exam prep questions available

 139-147
R
 HIV/AIDs: methods of detection/ diagnosis

147-151

May 4

 Wrap up / Course evaluations
Final Exam will be emailed to you by Monday am
  


Final Exam Due Monday May 11th before Noon (Turn in at my office)