Bio111: Molecules Genes and Cells, Prof Bernd
Reading Assignments Spring 2012

Assigned pages are Study Guide pages and include the reading and study questions that are to be prepared before that day's class.
Readings will be adjusted if needed (written assignment due days and times will not change, only content covered in those assignments).

UNIT I

Date Topic Study Guide pgs
Jan 18: W Introduction to course: What is a Cell? The Inner Life of a Cell
n/a
F

Unit 1: Stress Response and Sugar release (Cellular Communication)

Intro to polymers and basic molecule types (carbohydrates, amino acids, lipids)

1-7

Jan 23: M

Sugar release: Second messengers and signaling cascades. New molecule type--nucleic acids
Stopping the cascade: reversing and removing to get back to 'normal'

7-12
W Using the sugar
Your heart pounds-- Channels, Pumps and Muscle contractions part I
12-20
F

Using the sugar
Your heart pounds-- Muscle contractions part II
Myosin heads are dancin' song: http://www.biosongs.com/br3lyrics/6.html

continue
Jan 30:M

Legs don't fail me now-- synapses, membrane potentials and action potentials

20-25
W Legs don't fail me now-- from action potentials to chemical signals and back. Synaptic Vesicle release
25- 29

F

-- from action potentials to chemical signals and back. Synaptic Vesicle release

continue

Feb 6:
M

How does an egg know when it is fertilized? Another way of using 2nd messengers Fast and slow blocks--what are they and why do we need them?

29-35

W

Fast and slow blocks--what are they and why do we need them?

continue

F No Class Meeting Friday (I will be in Princeton) : Review1 will be emailed to you by 1pm Thursday and will cover pages 1-35 of Study Guide and first 4 weeks of Lab. It is DUE in my office by 9:20 Monday. See syllabus for details of late policy.  

UNIT II

Date Topic S G pgs
Feb 13 M

Review 1 Due before 9:20am.
Graphical analysis: prepping for your lab article. See Lab manual exercises
U
nit II Genetics Inherited diseases: Sickle Cell, Cystic Fibrosis, Huntingtons, Introduced

39-42
W

Unit II Genetics Inherited diseases: Sickle Cell, Cystic Fibrosis Huntingtons, Mitosis and Meiosis Review making and interpreting pedigrees,
Meiosis all rapped up http://www.biosongs.com/11.htm

continued
F

Inherited diseases: How do we talk about them?Traits vs alleles, genotypes vs. phenotypes, learning the terms and how to use them

42-45
Feb 20
M
Inherited diseases: DNA and an overview of gene expression (transcription and translation)
Cell cycle rap http://www.biosongs.com/10.htm

45-50
1st set of questions

W

Inherited diseases: The SRY example and the importance of mutations in evolution and the prevalence of silent mutation. Inherited diseases: Gene expression and revising the common definition of mutation
Sickle Cell-- differences in gene leading to differences in protein folding
Mitosis/meoisis/pedigree quiz available at the end of class (On Blackboard). Covers through pg 48

50-54
F Inherited diseases: Gene expression and revising the common definition of mutation
Sickle Cell-- differences in gene leading to differences in protein folding
54-58
Feb 27
M

Inherited Diseases: Intro to Cystic Fibrosis How do you begin searching when there is no 'obvious' protein? ReIntroduction to Mendel's Laws

58-62
W

Inherited diseases: Cystic Fibrosis: How to we find a gene in all that DNA:
'Classic' Linkage analysis / RFLPs and VNTRs
Mitosis/meoisis/pedigree quiz DUE before 11:59pm Wednesday night

62-67
F

Inherited diseases: Cystic fibrosis Continued

 

Mar 5

Spring Break  
Mar 12 M Inherited diseases: Cystic Fibrosis -- A chromosome is 'big'. How do we get closer: recombination 67-74
W Inherited diseases: Cystic Fibrosis-- Positional Cloning and Genomic approaches
Do, and check, questions found at this link
http://www.bio.davidson.edu/Courses/Bio111/campbell/CF_RFLP/RFLP_CF.html
74-77

F

Inherited diseases: Cystic Fibrosis-- What is the CF mutation? 77-80
Mar 19 M Inherited diseases: Cystic Fibrosis-- What is the problem and how can we tell?Review 2 will be emailed to you today, covers pages SG 39-83 and LM55-75 80-83

W

Class: Wrap up and Q&A. (optional) Come with questions  

UNIT III

Date Topic Study Guide pgs

Mar 23 F
Unit III: Bioenergetics: Poison Pot and an Introduction to energy
(note: starting new unit material but 2nd review still not due until Monday 3/26)
89-93

Mar 26 M

Review 2 DUE Before 9:20
Poison Pot: Light, Pigments and Energy
How and where do molecules store energy?
Listen to the kinetic and potential energy song http://www.acme.com/jef/science_songs/kinetic_potential-32.mp3
93-98
W Poison Pot: The Light Reactions and harvesting energy from photons
98-99
F No class meeting (Accompanying GSK scholars to Spring meeting)  
Apr 2 M Poison Pot: Calvin-Benson Cycle and making food
99-103

W

Cyanide and poison grapes: Only plants photosynthesize-- all cells metabolize glucose, how does that work? Cellular respiration (glycolysis/ Citric Acid Cycle and Oxidative Phosphorylation) webquiz available through Blackboard

103-107
F Pull together

continue

Apr 9 M Easter Break  
W Cyanide and poison grapes: Citric Acid Cycle and Oxidative Phosphorylation
107-112
F Cyanide and poison grapes: Citric Acid Cycle and Oxidative Phosphorylation
continue
Apr 16 M Why health officials require vaccinations during floods and 112-115

W

Carbon is not enough-- need nitrogen, but how? Amino Acid/ Peptide webquiz due by 5pm Friday
115-117
F Carbon is not enough-- need nitrogen, but how?
continue
Apr 23 M Pull together  

W

Wrap up and Question/Answer session .
Review 3 emailed to you today covers pages SG 88-117 and LM76-84
DUE before 9:20am on Monday

 

UNIT IV

Date Topic Study Guide pgs
F

MEET IN LAB -- Group colony counting

 
April 30 M Review 3 due before 9:20am
Unit IV: Other Interesting Topics
:
Epidemiology, Communicable diseases including HIV
 (note we are skipping a topic
)
A brief recap of human anatomy Final exam pre-questions emailed to you today.
131-136

W

HIV/AIDs: retroviruses
136-140

F

HIV/AIDs: Treatment approaches

140-147
May 7 M
HIV/AIDs: methods of detection/ diagnosis Wrap up
Final Exam will be emailed to you

147-151

  Available in office for questions
 
  Final Exam Due Monday May 14th before Noon (TURN IN TO MY OFFICE
No exam envelope, no exam center--> take home like other reviews