Biology 208
Cell Biology
Fall 2012

Course Syllabus: Expectations, Readings, Assignments, Lab Syllabus
Words of Wisdom from Previous Students

Lectures 'on-line':
Sometimes a picture is truly worth 1000 words, especially when talking about molecules that we can't see. To help our understanding some of your readings refer to animations found online. During some classes the animations and videos will be the major 'notes' for that day. In other classes powerpoint outlines will be used including appropriate text figures for later reference Word of 'warning': The Powerpoint files contain helpful images and the outline of the information covered --they cannot replace being in class and taking notes. They are questions and terms we will use to organize our discussion. The discussion itself is where the crux of the content will be worked through. Click on the Case Study Links below to access the index of these Powerpoint resources. Efforts will be made to have the ppt available by 7:45-8am (before class). Powerpoint files will all be available on-line after class. Access to these files is restricted to Davidson College Campus (you will have to sign in) to comply with copywrite laws regarding images the slides contain. See the class' Moodle page

Apoptosis animation: from Molecular Cell Biology, Lodish et al. 4th ed.

Fall 2012 Laboratory
Communication is very important to cell viability. Cells are doomed if they cannot react to their environment, signal to other cells or coordinate the action of internal organelles. The Cell biology lab is designed to explore facets of extracellular (between cells) and intracellular (within a cell) signaling using the mating reaction of yeast as a model system. The semester is divided into 3 major units during which you will discuss how scientists determine the quality and 'fundability' of scientific research, characterize 'normal' yeast mating, and design a research project that will characterize novel yeast strains containing defects in the mating reaction. The final unit is part of an ongoing project focused on elucidating the mechanisms of cell signaling, your data will be added to that of past groups in order to extend our current understanding of my collection of mating mutants.

Laboratory Manual
Download the lab manual sections: (Also available on Moodle)

Background, Safety and
Lab Prep

Characterizing the signal
Characterizing the effect of signaling;
morphologically I
Characterizing the effect of signaling;
morphologically II

Characterizing the effect of signaling; Differential Gene Expression


Grants & Funding mini-unit,

List of NSF abstracts
Innoculating Cultures

Taking Pictures

Mutant Characterization
Project Instructions

for article *

Test File:
All Reviews and the Final Exam are take-home exams. They are to be completed without the aid of outside materials and returned by the day and time indicated in the syllabus.

Please remember that the material and papers covered in each review will vary between years. Old reviews should be used as general guidelines for the types of questions that may be included.
    Review #1: '00,'01 '02, '03, SPR'05, Fall'05 '06
     Review #2:'00,'01 '02, '03 , SPR'05, '06
     Cumulative final exam 'pre-questions'-- Pre-questions are made available the Monday after Thanksgiving break. A subset of those questions will appear on the final exam. You may use any resources to prepare. Get together in study groups. Use your text. Use your time wisely and make sure you understand the material.
     Final Exam --The final exam has an atypical structure that is intended to help you reinforce course material so that you will remember the concepts far beyond this semester, rather than an info-purge on Dec 15th. The exam will be provided as two separate files: a cumulative portion containing a subset of the prequestions you were provided (verbatim, no tricks) and a 'Third review' portion covering Case Study 3. This is not an uber exam--the two parts, together, are as long in time required and number of points as one of the other midsemester exams. Both parts of the final will be emailed to you during optional days. Both parts must be completed without the use of any prewritten or outside material. You may complete one part, turn it in, and then study for and take the other part. Both parts must be turned in before noon on the Monday of exam week.

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