Biology 308
*Cell Biology*
Fall 2007

Course Syllabus: Expectations, Readings, Assignments, Lab Syllabus
Words of Wisdom from Previous Students

Lectures 'on-line':
Sometimes a picture is truly worth 1000 words so many of the readings refer to Cell Biology Interactive-- the CD-rom that is packaged with your text book (If you purchased your book used make sure that you have the CD-rom . During some classes the animations and videos on that CD-ROM will be the major 'notes' for that day. In other lectures appropriate text figures will be mentioned in class for later reference and Powerpoint lectures or lecture outlines are available on-line after class. Access to these files is restricted to Davidson College Campus to comply with copywrite laws regarding images the slides contain.Word of 'warning': The Powerpoints for lectures contain helpful images and the outline of the information covered. They are questions and terms we will use to organize our discussion --they cannot replace being in class and taking notes. Click on the Case Study Links to access the index of these Powerpoint resources. (files become available 7:30am on day of class)

Case Study 1: Grave's Disease Case Study 2:
Bipolar Disorder
Case Study 3:
Werner's Syndrome

Apoptosis animation: from Molecular Cell Biology, Lodish et al. 4th ed.

Fall 2007 Laboratory
Communication is very important to cell viability. Cells are doomed if they cannot react to their environment, signal to other cells or coordinate the action of internal organelles. The Cell biology lab is designed to explore facets of extracellular (between cells) and intracellular (within a cell) signaling using the mating reaction of yeast as a model system. The semester is divided into 3 major units during which you will discuss how scientists determine the quality and 'fundability' of scientific research, characterize 'normal' yeast mating, and design a research project that will characterize novel yeast strains containing defects in the mating reaction. The final unit is part of an ongoing project focused on elucidating the mechanisms of cell signaling, your data will be added to that of past groups in order to extend our current understanding of my collection of mating mutants.

Fall 2007 Laboratory Manual
Download the lab manual sections:

Background, Safety and
Lab Prep

Characterizing the signal
Characterizing the effect of signaling;
morphologically I
Characterizing the effect of signaling;
morphologically II

Characterizing the effect of signaling; Differential Gene Expression

Bardwell

Grants & Funding mini-unit,

List of NSF abstracts

 

  *INSTRUCTIONS
for article
*
<<read these

Test File:
All Reviews and the Final Exam are take-home exams. They are to be completed without the aid of outside materials and returned by the day and time indicated in the syllabus.

Please remember that the material and papers covered in each review will vary between years. Old reviews should be used as general guidelines for the types of questions that may be included.
    Review #1: '98, '99,'00,'01 '02, '03, SPR'05, Fall'05 '06
     Review #2: '98, '99,'00,'01 '02, '03 , SPR'05, Fall'05 '06
     Review #3: '98, '99 (the course no longer has a third in-semester review)
     Cumulative final exam 'pre-questions'-- Pre-questions are made available on Monday Nov 27th. A subset of those questions will appear on the final exam. You may use any resources to prepare. Get together in study groups. Use your text. Use your time wisely and make sure you understand the material. For the actual final exam, you may NOT use any prewritten answers or outside material --only the information contained within your head.
     Final Exam -- The structure of the final exam is intended to help you reinforce course material so that you will remember the concepts far beyond this semester (rather than an info-purge on Dec 17th). The exam will be provided as two separate files: a cumulative portion containing a subset of the prequestions you were provided on Nov 30th and a 'Fourth review' portion covering Case Study 3. Together the two parts are as long (in time required and number of points) as one of the other midterm reviews. Both parts of the final will be emailed to you on Dec 10th. Both parts must be completed without the use of any prewritten or outside material. You may complete one part, turn it in, and then study for and take the other part. Both parts must be turned in before 11am on Monday Dec 17th.

WWWeb Links
    In past years the class included an assignment in which students found, evaluated and annotated WWWeb sites that provided background material on topics that will be covered in class. Their top picks are the basis for this list of reference material.
General Sites Biological membranes Protein Synthesis
Protein targeting Intracellular trafficking (vesicular traffic) Cellular Scaffolding
Molecular motors Intracellular signaling Extracellular communication
Protein Degradation Cell Cycle Apoptosis

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