From Venoms and Toxins to Drugs: Fall
2001
Seminar Information
Focus
Schedule
Grading
Focus: This seminar
will include student lead discussion of topics such as: research supporting/disproving
cellular benefits of herbal supplements, uses of dietary supplements (glucosamine
chondroitin, creatine) and toxic substances used for medicinal purposes
(taxol, thalidomide, lithium, various snake venoms). The overall focus
of the seminar is to look at the use of naturally occurring substances
for medicinal purposes. The class will determine exactly how this topic
is developed. The title indicates venoms or toxins, this is in reference
to the fact that many chemotherapeutic drugs are exceedingly toxic but
also life-saving and that deadly venoms are used for cosmetic purposes.
The 'drug' part comes in to cover development of other substances--remembering
that most of our drugs had 'natural' beginnings. Aspirin 'comes from' tree
bark. Morphine 'comes from' the poppy seed. From ideas generated by the
class we will decide on main topics for discussion. Within one of these
topics, you will develop an individual topic which will be the focus of
your final webproject.
Before the first class you should have an
idea of one or two topics on which you would be interested in focusing.
(Read on to get ideas). There is no formal textbook for the class. You
will need a ZIP disc. The lab we will meet in for web workshops s equipped
with Mac G3's which do not have 3 1/2" disc drives ('normal discs'). You
can purchase a Mac or an IBM formatted ZIP disc, either will work in a
Mac. If you are totally opposed to working on a Mac I should be able to
arrange for access to departmental Dells although NOT during scheduled
class periods.
During the semester you prepare two presentations
(using Powerpoint), lead a discussion of a journal article, make a personal
homepage, prepare a web site as a class, and prepare a final webproject
that explores your topic in depth.
I do not expect that you are proficient in
Powerpoint presentations or that you have ever made a webpage before. The
course includes instruction in those areas. I do expect that you
are relatively comfortable using a computer (word processing, familiar
with the fact that the wwweb exists) and that you know how to access your
Davidson NT server space ('Louise'). If any of these are not the case please
speak to me and/or the helpdesk. For Webauthoring I will provide instruction
using Netscape Composer. Macromedia Dreamweaver is available through the
department and you may use it (or any other) program but since I have not
used it I cannot provide support for Dreamweaver.
A MAIN POINT: All topics must include a discussion
of how the substance acts at the cellular level. Such as why is Botox good
at getting rid of 'crows feet' wrinkles? What does it do to the cells?
Do we know why or what part of St John's Wort causes it to be effective
in maintaining 'mental stability'? Other areas for discussion could include
pros' and cons of using the substance (uses and abuses in some cases) and
any controversy over the topic (public opinion vs. reality, inappropriate
good press, inappropriate bad press, who can patent what and why)
The class project will include discussion of drug
testing --what the process is and how it works. A twist on this topic could
be to include the treatment of syphillis and government experiments in
the 40's where people were (unknowningly) exposed to the disease. Besides
discussing the trouble with getting 'test subjects' and the obvious ethical
implications of that work, you would need to include a discussion of what
syphillis is and why it ends up making people 'go mad'--what happens at
the level of the neuron?
How will the
seminar work? (Syllabus)
We meet once a week for 3 hours.
Since you have taken other Bio courses you are used to a 3hour lab format
but a 3 hour discussion class may seem daunting. Each class will have more
than one component. Our focus and assignments for each week are listed
below. Each component is separated by a (---) in the syllabus below. At
this time this is a rough outline since the presentation schedule will
be determined after classes begin. Note that in many cases assignments
are submitted electronically and are due throughtout the week--not just
on Thursdays.
Week 1 (Aug 20th) Our first classes will
cover many of the mechanics with which you will need to be familiar. We
will devise a scale for ranking websites by composition and content. Frank
Molinek will provide instruction on performing online literature searches
and references resources within Little library. We will go over how to
prepare a Powerpoint presentation. Last, but definitely not least, we will
discuss the ideas/directions that you want to develop. You will be assigned
a website to evaluate using the criteria that the class designed.
Week 2 (Aug 27th) Your evaluations will be
emailed to me by 5pm Monday(2page MAX) and will be presented in
class (tour of the site noting strengths and weaknesses). By 12:30pm
Thursday you will email me an annotated bibliography containing 5 references
that are pertinent to your topic. (You will be adding to this bibliography
throughout the semester.) You may find that you need to revise your topic.
That is fine but you must discuss it with me before change directions.
-----
In class we will discuss the websites you evaluated
and the rating scale. I will meet with each of you to discuss your project
topic. The personal homepage assignment will be discussed and the class
will develop a plan for the class project "Gaining Approval".
Week 3 (Sept 3rd) By 5pm Tuesday you
will email me 3 more annotated references for your project. In class you
will present a proposal for the topic and approach of your topic (10min
max). The class will provide comments and suggestions.
------
We will have a workshop to search for sources for
the course website, 'storyboard' how the site will be laid out and help
with any problems in preparing your personal webpage.
For Week 4 you should find and bring resources,
write up rough copy to use for the class site
Week 4 (Sept 10th) Homepage due 5pm Monday
Presentation of background material and into to first article for discussion
(topic TBA: presentation by Dr Bernd)
------
Work time for class project. Finalize rough design/setup.
Week 5 ( Sept17th) Due in class: 2 topics
for discussion and appropriate reading
Discussion of First article (lead by Dr Bernd) Secretary
takes minutes of discussion and distributes (via email) by noon Sunday.
-----
Meetings with me to discuss/defend proposed discussion
topics
Work time for group page and presentation
Week 6 (Sept 24th) Gaining Approval
course page due 5pm Saturday (SEPTEMBER 22nd!)
Powerpoint Presentation of 'Gaining Approval'--(not
just reading of website.)
College community will be invited.
Week 7 (Oct 1st) Due in class: Reading list for your
article discussion-- including pages/text background readings when appropriate
and copy of article for discussion,
Film viewing and discussion (title TBA)
Week 8 (Oct 8th) Background for discussion 2: Joey, Lauran,
and John (+ Secretaries)
Discussion of progress/problems in individual projects
Week 9 (Oct 15th) Article Discussion 2: Joey, Lauran,
and John (+ Secretaries)
Those not leading discussion --3 annotated references due.
-----
Web help, work on projects. (Bring material to work on!)
Week 10 (Oct 22nd) Background for discussion 3: Paul,
Jeffrey, Amy and Julie (+ Secretaries)
Discussion of progress/problems in individual projects
Week 11 (Oct 29th) Article Discussion 3: Paul, Jeffrey,
Amy and Julie (+ Secretaries)
Those not leading discussion --3 annotated references due.
-----
Round table: each student informally presents current progress on final
project (possible points includinc development of theme, resources found,
storyboard plan)
Week 12 (Nov 5th) Background for discussion 4: Max, Andre and
Lane (+ Secretaries)
Discussion of progress/problems in individual projects
Week 13 (Nov 12th) Article Discussion 4: Max, Andre and Lane
(+ Secretaries)
Those not leading discussion --3 annotated references due.
-----
Meetings with me to discuss progress on final projects
Submit film requests.
Week 14 (Nov 19th) Thanksgiving: No Class (Show off your work
in progress to friends, family)
Week 15 (Nov 26th) Film viewing and discussion
Final webproject due Monday December 3rd by 8pm.
Individual projects: The entire semester
will be used to develop an individual project related to the course theme.
For example your topic could be the identification and development of taxol
(from the Yew tree) as a chemotherapeutic drug. Your individual project
will consist of a series of webpages devoted to exploring/explaining your
topic. You project must have a 'homepage' that introduces the topic, how
it relates to the course and where you will be going with it. Each individual
project must contain at least one webpage (that you wrote--not just a link)
that discusses the specific cellular mechanism(s) effected by the compound
(perhaps a discussion of how taxol effects microtubule formation). All
webpages should be backed up by appropriate research and in text references
(included on the site). No more than 50% of your references should be websites.
The entire site must contain least 6 (but no more than 9) additional pages
that you wrote (not just outside links). The entire project is due by 8pm
on Monday December 3rd .
Grading: This is a
seminar, therefore, a good deal of participation is expected and is a major
component of your overall evaluation. Your group will have meetings outside
of formal 'class time' and your preparation, attendance and participation
at those meetings also forms part of this evaluation. Your numerical grade
will be based on the following categories.
Participation |
20% |
Evaluation of webpage (2pg) |
2% |
Project proposal |
2% |
'Gaining Approval'
Website and presentation |
25% |
Secretarial role |
2% |
Background Presentation and
Leading Discussion |
18% |
Individual Web project |
|
Annotated Bibliography |
3% |
Personal page prep |
3% |
Final Project site |
25% |
Group assignments (2 presentations, project proposal
and group project website) will receive one evaluation (with comments)
per group. Each member of the group is expected to have contributed equally
to the preparation and presentation of the material. Peer evaluations will
also be used (completed both by group members and classmates).
Your numerical evaluation will be converted into
a course grade using the following scale:
Letter grade |
B+ = 3.3 =
87-89 |
C+ = 2.3 =
77-79 |
D+ = 1.3 =
67-69 |
|
A =4.0 =93-100 |
B = 3.0 = 83-86 |
C = 2.0 = 73-76 |
D = 1.0 = 60-66 |
F = below 60 |
A- =3.7 = 90-92 |
B- = 2.7 =
80-82 |
C- = 1.7 =
70-72 |
|
|
© Copyright 2001 Department of Biology, Davidson College, Davidson,
NC 28036
Send comments, questions, and suggestions to: kabernd@davidson.edu