Education

Ph.D., 1997, Stanford University School of Medicine, Department of Genetics.
Thesis advisor: Dr. Margaret T. Fuller.
Thesis title: Genetic control of mitochondrial morphogenesis during Drosophila spermatogenesis.

B.A., 1991, Swarthmore College.
Distinction in Biology, Phi Beta Kappa.

Academic Appointments

Associate Professor of Biology, August 2006-present, Davidson College.

Assistant Professor of Biology, August 2000-July 2006, Davidson College.

Instructor, Summer 2000 and Summer 1999, University of North Carolina at Chapel Hill, Department of Biology.

Postdoctoral Fellow, 1998-2000, University of North Carolina at Chapel Hill.
Genetic analysis of septin protein function in Drosophila.
Advisors: Dr. John R. Pringle and Dr. Mark Peifer.

Undergraduate Research Associate, Summer 1990, Department of Biology and Howard Hughes Medical Institute Interdisciplinary Laboratory, Swarthmore College. Requirement for cysteine residues in the Shigella MerT protein for mercury reduction. Advisors: Dr. Nancy V. Hamlett and Dr. Judith Voet.

Grants, Fellowships, Honors, and Awards

National Institutes of Health Academic Research Enhancement Award (AREA), 2007-2010
MacArthur Assistant Professor of Biology (named professorship), Davidson College, 2003-2005.
National Science Foundation Faculty Early Career Development Award (CAREER), 2002-2007.
National Institutes of Health Postdoctoral Fellowship, May 1999-July 2000.
Howard Hughes Medical Institute Predoctoral Fellowship, 1991-1996.
National Science Foundation Graduate Fellowship (declined), 1991.
Leo Leva Memorial Prize in Biology (departmental award), Swarthmore College, 1991.
Gladys Irish Prize in Athletics, Swarthmore College, 1991.
Phi Beta Kappa, 1991.
Sigma Xi, 1991.
National Merit Scholarship, 1987.

Publications
Articles and Patents (* indicates undergraduate coauthors)

Silverman-Gavrila, R.V., Hales, K.G.,and A. Wilde. 2008. Anillin-mediated targeting of Peanut to pseudocleavage furrows is regulated by the GTPase Ran. Mol. Biol. Cell. in press.

Aldridge, A.C., L.P. Benson*, M.M. Siegenthaler*, B.T. Whigham*, R. S. Stowers, and K.G. Hales. 2007. Roles for Drp1, a dynamin-related protein, and Milton, a kinesin-associated protein, in mitochondrial segregation, unfurling, and elongation during Drosophila spermatogenesis. FLY 1: 38-46.

Fuller, M.T., K.G. Hales, and A.H. Santel. 2005. Mitofusins, Fzo homologs, and functional derivatives thereof. United States Patent 6,953,680.

Beckstead, R.B., S.S. Ner, K.G. Hales, T.A. Grigliatti, B.S. Baker, and H.J. Bellen. 2005. Bonus, a TIF1 homologue, interacts with heterochromatin and is an enhancer and suppressor of position effect variegation. Genetics 169: 783-794.

Hales, K.G. 2004. The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis. Mitochondrion 4: 285-308.

Hales, K.G. 2003. Review of Decoding Darkness: In Search of the Genetic Causes of Alzheimer's Disease by Rudolph E. Tanzi and Ann B. Parson. Journal of Undergraduate Neuroscience Education 1(2): R12-R13. PDF.

Shih, H.-P., K.G. Hales, J.R. Pringle, and M. Peifer. 2002. Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. J. Cell Sci 115: 1259-1271. PDF.

Hales, K.G. 2001. "Finding a Lost Mouse" Refined. The American Biology Teacher 63: 470.

Fuller, M.T. and K.G. Hales. 2001. Mitofusin genes and their uses. United States Patent 6,284,507.

Fuller, M.T. and K.G. Hales. 2000. Mitofusin genes and their uses. United States Patent 6,127,159.

Hales, K.G., E. Bi, J.-Q. Wu, J.C. Adam, I.-C. Yu, and J.R. Pringle. 1999. Cytokinesis: an emerging unified theory for eukaryotes? Curr. Opin. Cell Biol. 11: 717-725. PDF.

Hermann, G.J., J. Thatcher, J. P. Mills, K.G. Hales, M. T. Fuller, J. Nunnari, and J. M. Shaw. 1998. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143: 359-373. PDF.

Molina, I., S. Baars, J. A. Brill, K. G. Hales, M.T. Fuller, and P. Ripoll. 1997. A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. J. Cell Biol. 139: 1361-1371. PDF.

Hales, K.G. and M.T. Fuller. 1997. Developmentally regulated mitochondrial fusion mediated by a conserved novel predicted GTPase. Cell 90: 121-129. PDF.

Abstracts (* indicates undergraduate coauthors)

*English, B.C., *S. D. Durnbaugh, *K. M. Koehrn, *S. H. Holmberg, S. E. Favors, K. G. Hales. 2008. Characterization of the hypomorphic male sterile nmd^ry4 allele and analysis of the nmd paralog
CG4701’s putative role in spermatid mitochondrial shaping. 49th Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts 496A.

*Wood, K. H., *L. M. Bergner, *F. E. Hickman, *M. C. Beaucaire, A. C. Aldridge, S. E. Favors, K. G. Hales. 2008. Cloning and characterization of mitoshell, a gene required for normal mitochondrial aggregation during Drosophila spermatogenesis. 49th Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts 505A.

Favors, S.E., K.G. Hales. 2008. Separation of Nebenkern anchoring and mitochondrial elongation phenotypes in germ line clones of a milton allele.49th Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts 497B.

*Wood, K. H., *L. M. Bergner, *F. E. Hickman, S. E. Favors, A. C. Aldridge, K. G. Hales. 2007. Identification of a Drosophila gene required for proper timing and configuration of mitochondrial aggregation during spermatogenesis. 47th Annual Meeting of the American Society for Cell Biology (Washington, DC). Late Abstracts Volume 2806.

Hales, K.G., *S. E. Coffey, S. E. Favors, A. C. Aldridge. 2007. Roles for mitoshell in mitochondrial aggregation and meiotic cytokinesis during Drosophila spermatogenesis. 48th Annual Drosophila Research Conference (Philadelphia, PA), Program and Abstracts 532A.

*English, B.C., *S. D. Durnbaugh, *K. M. Koehrn, A. C. Aldridge, S. H. Holmberg, K. G. Hales. 2007. Characterization of nmd and its paralog in mitochondrial morphogenesis in Drosophila spermatogenesis. 48th Annual Drosophila Research Conference (Philadelphia, PA), Program and Abstracts 530B.

Aldridge, A. C., *S. E. Coffey, *B. C. English, S. E. Favors, K. G. Hales. 2006. Roles for mitoshell in mitochondrial aggregation and meiotic cytokinesis in Drosophila spermatogenesis. 46th Annual Meeting of the American Society for Cell Biology (San Diego, CA). Late Abstracts Volume L113(W).

*Durnbaugh, S.D., *K.M. Koehrn, A.C. Aldridge, *C.M. Black, *K.O. Saunders, *S.H. Holmberg, and K.G. Hales. 2006. Function of no mitochondrial derivative  in mitochondrial morphogenesis during spermatogenesis. 47th Annual Drosophila Research Conference (Houston, TX), Program and Abstracts 497A.

Hales, K.G., *L.P. Benson, *M.M. Siegenthaler, *B.T. Whigham, R.S. Stowers, and A.C. Aldridge. 2006. Roles for milton and Drp1 in mitochondrial morphogenesis during Drosophila spermatogenesis. 47th Annual Drosophila Research Conference (Houston, TX), Program and Abstracts 500A.

Aldridge, A.C., *L.P. Benson, *M.M. Siegenthaler, *B.T. Whigham, R.S. Stowers, and K.G. Hales. 2005. Roles for milton and Drp1 in mitochondrial morphogenesis during Drosophila spermatogenesis. 45th Annual Meeting of the American Society for Cell Biology (San Francisco, CA). Late Abstracts Volume L407.

*Whigham, B.T., *M. M. Siegenthaler, R. S. Stowers, and K.G. Hales. 2005. Milton functions in mitochondrial elongation during Drosophila spermatogenesis. 46th Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts 577A.

*Baxley, S.E., *Holmberg, S.H., *Burke, S.T., Aldridge, A.C., *Black, C.M., *Whigham, B.T., and K.G. Hales. 2004. Genetic control of mitochondrial aggregation during Drosophila spermatogenesis: characterization of the no mitochondrial derivative and mitoshell genes. 44th  Annual Meeting of the American Society for Cell Biology (Washington, DC). Late Abstracts L318.

*Baxley, S.E., *S.T. Burke, and K.G. Hales. 2004. Genetic control of mitochondrial aggregation during spermatogenesis: characterization of an nmd candidate gene. 45th Annual Drosophila Research Conference (Washington, DC), Program and Abstracts 587B.

*Holmberg, S.H. and K.G. Hales. 2004. Characterization of the subcellular localization of the nmd gene product. 45th Annual Drosophila Research Conference (Washington, DC), Program and Abstracts 592A.

Hales, K.G. 2003. Synthesizing molecular and classical genetics in inquiry-based laboratory courses for undergraduates. 43rd Annual Meeting of the American Society for Cell Biology (San Francisco, CA). Late Abstracts L414.

*Siegenthaler, M.M., R. S. Stowers, and K. G. Hales. 2003. Role of milton in mitochondrial morphogenesis during Drosophila spermatogenesis. 44th Annual Drosophila Research Conference (Chicago, IL), Program and Abstracts: 648C.

*Burke, S.T., *J.F. Sturgill, N. Wolf, M.T. Fuller, and K.G. Hales. 2002. Genetic control of mitochondrial aggregation during Drosophila melanogaster spermatogenesis. 2002 Meeting on Germ Cells (Cold Spring Harbor, NY, October 2002).

*Burke, S.T., *J.F. Sturgill, N. Wolf, M.T. Fuller, and K.G. Hales. 2002. Identification of a candidate gene for no mitochondrial derivative (nmd). 43rd Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts: 631A.

*Burke, S., *J.F. Sturgill, and K.G. Hales. 2001. Molecular cloning of the nmd gene in Drosophila melanogaster. Sigma Xi Student Research Symposium (Raleigh, NC), D10.

Hales, K.G. 2001. A semester-long laboratory project synthesizing molecular and classical approaches to gene mapping and cloning. 42nd Annual Drosophila Research Conference (Washington, DC), Program and Abstracts: 3W.

Hales, K.G., M. Peifer, and J.R. Pringle. 2000. Genetic analysis of the Sep2 and Sep5 septins. 41^st Annual Drosophila Research Conference (Pittsburgh, PA), Program and Abstracts: 456B.

Shih, H.-P., K.G. Hales, M. Peifer, and J.R. Pringle. 2000. Identification and characterization of a Drosophila ubiquitin-like protein conjugation pathway that may be involved in septin modification. 41^st Annual Drosophila Research Conference (Pittsburgh, PA), Program and Abstracts: 35.

Hales, K.G., O. Al-Awar, M. Peifer, and J.R. Pringle. 1999. Immunolocalization, structural studies, and genetic analysis of the Sep2 septin. 40th Annual Drosophila Research Conference (Bellevue, WA), Program and Abstracts: 292C.

Hales, K.G. and M.T. Fuller. 1997. Novel predicted GTPase is required for developmentally regulated mitochondrial fusion during spermatogenesis. 38th Annual Drosophila Research Conference (Chicago, IL), Program and Abstracts: 13C.

Hales, K.G. and M.T. Fuller. 1996. A novel transmembrane GTPase is required for developmentally regulated mitochondrial fusion during Drosophila spermatogenesis. 6th International Congress on Cell Biology and 36th Annual Meeting of the American Society for Cell Biology (San Francisco, CA). Molec. Biol. Cell 7: 615a.

Hales, K.G. and M.T. Fuller. 1996. The Drosophila fuzzy onions gene encodes a putative GTPase required for mitochondrial fusion during spematogenesis. Howard Hughes Medical Institute Meeting of Predoctoral and Physician Postdoctoral Fellows (Chevy Chase, MD), Program and Abstracts: 49.

Hales, K.G. and M.T. Fuller. 1996. Genetic control of mitochondrial fusion during spermatogenesis: cloning of the fuzzy onions gene. 37th Annual Drosophila Research Conference (San Diego, CA), Program and Abstracts: 221B.

Hales, K.G. and M.T. Fuller. 1995. The fuzzy onions gene affects mitochondrial fusion during spermatogenesis. 36th Annual Drosophila Research Conference (Atlanta, GA), Program and Abstracts: 137A.

Hales, K.G. and M.T. Fuller. 1994. Genetic control of mitochondrial morphogenesis during spermatogenesis in Drosophila. 34th Annual Meeting of the American Society for Cell Biology (San Francisco, CA). Molec. Biol. Cell 5: 99a.

Hales, K. and M. Fuller. 1994. Genetic control of mitochondrial morphogenesis during spermatogenesis. 35th Annual Drosophila Research Conference (Chicago, IL), Program and Abstracts: 110A.

Fuller, M.T., K. Hales, I. Molina, and G. Hime. 1993. Cellular mechanisms of spermatid differentiation. 33rd Annual Meeting of the American Society for Cell Biology (New Orleans, LA). Molec. Biol. Cell 4: 30a.

Professional Activities
Workshops

Drosophila Research and Pedagogy at Primarily Undergraduate Institutions. Co-organizer and co-moderator. 46th Annual Drosophila Research Conference (San Diego, CA), March 30-April 3, 2005.

Drosophila Research and Pedagogy at Primarily Undergraduate Institutions. Co-organizer and co-moderator. 45th Annual Drosophila Research Conference (Washington, DC), March 24-28, 2004.

Research and Pedagogy at Primarily Undergraduate Institutions. Co-organizer and co-moderator. 44th Annual Drosophila Research Conference (Chicago, IL), March 5-9, 2003.

Drosophila Research at Primarily Undergraduate Institutions. Co-organizer and co-moderator. 42nd Annual Drosophila Research Conference (Washington, DC), March 21-25, 2001.

Panels

Alternative Career Paths: Life after Stanford. Stanford University School of Medicine Department of Genetics Annual Scientific Meeting (Monterey, CA) September 17-19, 2003.

Careers at Primarily Undergraduate Institutions. 42nd Annual Drosophila Research Conference (Washington, DC), March 21-25, 2001.

Memberships

Genetics Society of America
American Society for Cell Biology
Sigma Xi Research Society

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last modified June 20, 2008 by K. Hales