Bio111 Reading Schedule for Dr. Campbell - Spring 2008

Date
Topic
Reading
Assignment
M Jan 14

Introduction to Course; send Dr. C. email; tour web site; VARK survey
Cells are amazing!

N/A
 
Unit I: Cell Biology
 
  How does your liver add glucose to your blood when scared? Learning Goals
W Jan 16

stop at "We are now ready to put the elements...."
Jmol of carbohydrates (polysaccharides)
Jmol of protein structure (Alpha helix & Beta strand)
IDH monomer as model protein (and used in 111 lab)
IDH dimer with quaternary structure

Amino acids and polarity/charge in Jmol

p 1 - 7
stop after question 7
F Jan 18 stop at "How the Heart Pounds in Response to Stress"
Jmol of lipid bilayer
Jmol of cAMP vs. ATP
G protein with GDP (with α, β and γ subunits)
  
p 7 - 12
M Jan 21 no classes for MLK celebration  
  Why does your heart beat harder when your scared? Learning Goals
W Jan 23 stop at "OK, let’s get back to the myocardial cell."
Simplified ion channel (phospholamban Ca channel)
Calcium pump in the SR
Calcium pump cycle
(animated gif)
Muscle contraction movie
p 12 - 18
stop after question 5

F Jan 25
stop at "How Neurons Signal Muscles to Contract"
Myosin cycle movie
Calcium regulation of myosin binding movie
Muscle contraction movie
Calcium fills SER
p 18 - 20
  How do you get your muscles to move? Learning Goals
M Jan 28

stop at "Action potentials are very fast and the wave of...."
Active Transport (animation)
Resting Membrane Potential (animation)
Stadium Wave video (Brazil)
Action potential (animation)
Nerve terminus
Look for actin fibers and exocytosis in this familiar movie.
Calcium pump in the SR

p 20 - 25
stop after
News Item
W Jan 30 stop at "How An Egg Learns It Has Been Fertilized"
p 25 - 29
  How does an egg know when it's fertilized? Learning Goals
F Feb 1 stop at "Other Cellular Communication Systems"
Pronuclei fusing M = male pronucleus and F = female pronucleus
p 29 - 35
start with the second page 29
  Additional Research Questions and Methods

Learning Goals

M Feb 4 stop at end of page
Gel electrophoresis (figures only)
Gel electrophoresis (animation)
Calculating molecular weights
How big are proteins?
Antibody structure

Immunofluorescence
Western blot method
p 35 - 38
W Feb 6 Buffer Day To Catch Up and Clarify
Watch for vesicle movement and exocytosis in this familiar movie.
no new reading
F Feb 8 First Take Home Exam Due Monday Feb. 11  
M Feb 11 Turn in Take Home Exam + First In Class Exam
Due at 12:30 pm

 

Date
Topic
Reading
Assignment
 
Unit II: Genetics and Molecular Biology
 
  3 Genetic Diseases - Background Information Learning Goals
W Feb 13 stop at "What can we tell about the genetic inheritance...."
dsDNA in Jmol
ATP structure in Jmol
DNA polymerase adding a base
Morphed Movie of Mitosis (3.5 MB)
Real Movie of plant mitosis (7.6 MB)
Real Movie of animal mitosis (2.7 MB)
Real Movie of yeast mitosis (5 MB)
p 39 - 42
stop after first
question #3, top
of column
  Classical Genetics Learning Goals
F Feb 15 stop at "We need to stop and look at how wild-type...."
Karyotyping (interactive site)
p 42 - 46
stop after question
M Feb 18 stop at " When we talk about mutations, it is a common...."
DNA replication (front view)
DNA replication (back left view)
DNA replication (back right view)
DNA replication (view from above)
Chromosome packing (7 MB movie)
from www.wehi.edu.au/education/wehi-tv/dna/index.html
p 46 - 50
stop after
picture of gel
  Mitosis, Meiosis & Cell Cycle Closed Book Quiz - due 4 pm Friday Feb 22  
  Molecular Genetics Learning Goals
W Feb 20 stop at "While we do not understand the cell or...."
Genetic Code
Transcription (5 MB file)
SRY Jmol structure
Translation (11 MB file)
Compare two tRNAs (Jmol)
p 50 - 55
stop after
question #2
F Feb 22 stop at "Investigators working on specific diseases usually...."
Hemoglobin tetramer (Jmol)
p 55 - 60
stop after News Item
  Molecular Traits of 3 Diseases Learning Goals
M Feb 25

stop at "In recent years, DNA fingerprinting has become...."
Restriction Enzyme Cutting DNA (4 MB file)
Gel electrophoresis (animation)

p 60 - 66
stop after
question #10
W Feb 27 Review Session in Class Second Take Home Exam Due Friday Feb. 29
Look for translation in this familiar movie.
Narrated version of cell animation at YouTube
Structure of ddATP in Jmol

DNA sequencing (dideoxy method)
DNA sequencing (cycle sequencing method)
 
 
F Feb 29
Turn in Take Home Exam + Second In Class Exam
Due at 12:30 pm


Date
Topic
Reading
Assignment
M Mar 3
Spring Break
Use Sunscreen
W Mar 5
Spring Break
Sleep
F Mar 6
Spring Break
Use Sunscreen
  Cloning Disease Genes Learning Goals
M Mar 10

stop at "The search for the CF gene had been...."
Linkage with RFLP Markers and cf alleles
How accurate are genetic tests?

p 66 - 74
stop after
question #7
W Mar 12

stop at "The DNA encoding the wild-type allele at the...."
Structure of ddATP in Jmol

DNA sequencing (dideoxy method)
DNA sequencing (cycle sequencing method)
Reverse Transcriptase (stop when dsDNA completed)
Genome Browser Exploration for CFTR

p 74 - 77
stop after
question #6
F Mar 14 stop at "If our initial hypothesis is not...."
Flagella Images
Evolution of Flagella (bacterial) (Ken Miller at YouTube)
p 77 - 80
stop after web
reading
M Mar 17 stop at "Huntington’s – A Dominant Neurodegenerative Disease...."
Liposomes
ER vs. PM labeling
Safety Concerns of Gene Therapy (Jesse Gelsinger)
Gene Therapy Stopped
p 80 - 83
W Mar 19 stop at "Sex-linked genetic disorders...."
Hunting for Huntington's Disease
HD Pedigree
Bayes' Rule for Genetic Testing
Eugenics History
James Watson - controversial figure
p 83 - 86
  Sex-linked Genetic Disorders Learning Goals
F Mar 21 stop at end of page p 87 - 88
M Mar 24
Easter Break
 


Date
Topic
Reading
Assignment
W Mar 26 Mini-Exam: Take Home Exam Due Monday Friday Mar 28  
F Mar 28 Turn in Take Home Exam + Mini-Exam In Class Due at 12:30 pm
  Unit III: Biochemistry  
  Why Poisoned Pot? Learning Goals
M Mar 31 stop at "Chlorophyll harvests light energy by passing...."
Chlorophyll structure
p 89 - 95
stop after
question #3
W Apr 2   stop at "Synthesizing Food: The Calvin-Benson Cycle"
Jmol Structures of Photosynthesis
p 95 - 99
F Apr 4 stop at "Question #2:  Why is Cyanide Poisonous?" p 99 - 103
 
Why is cyanide poison of choice?
Learning Goals
M Apr 7
stop at "Look over all the steps in glycolysis and the...."
p 103 - 107
stop after
question #4
W Apr 9 stop at "ATP synthesis in photosynthesis and oxidative...."
Glycolysis
p 107 - 112
F Apr 11 Buffer Day  
  Why update your vaccines? Why eat tofu?
Learning Goals
M Apr 14 Tofu Pups
Rhizobium nodules
Clostridium affects neurotransmitter release
stop at "Two Research Questions...."
How much energy does this require...?
Narrated version of cell animation at YouTube
Third Exam: Take Home Exam Due Wed Apr. 16
p 112 - 117
W Apr 16 Turn in Take Home Exam + Third In-Class Exam Due at 12:30 pm


Date
Topic
Reading
Assignment
 
Unit IV: Biology In The News
 
  Cancer Biology Learning Goals
F Apr 18 stop at "What do we know now about cell division that...."
MRIs of Tumors
Cancer Statistics
Does smoking cause cancer?
p 119 - 123
stop after
question #8
M Apr 21 stop at "In order to illustrate some of the normal...."
Infection rates in American teenage girls
p 123 - 127
stop after
question #6
W Apr 23 Karyotyping
Large Tumor (93 lbs)
Gigantic tumor removed (video)
CancerQuest Animations
(Emory) Gigantic tumor removed
Inside Cancer Animations (CSHL)
stop at "AIDS & HIV"
p 127 - 132
 

HIV/AIDS Biology

Learning Goals
F Apr 25 p 132 - 140
stop after
News Items
M Apr 28

p 140 - 148
stop at
Diagnosis...

W Apr 30
stop at "Genetic Engineering"
Bayes' Rule for Genetic Testing
Reliability of HIV Test Results
Western blot method
TMA Method (developed by Davidson Alumnus Larry Mimms)
p 148 - 152
  Genetic Engineering Learning Goals
F May 2

stop at end of page
A-maizing antibody
Raelians - cloning humans
Links from Dr. Haynes

p 152 - 156
 
Final Exam is Pseudo-Cumulative
 
M May 5 Fellowship Talk and Course Evaluations
Amy Reid Bio Major Wins Watson in 2007
 
W May 7 Final In Class Exam + Take Home Exam
Narrated version of cell animation at YouTube
 
 
Final Exam - Due by Noon May 12
 


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