This webpage was produced as an assignment for an undergraduate course at Davidson College.

Helicobacter pylori:

This site is intended to discuss the pathogen Helicobacter pylori.  It goes into detail on the pathogen life cycle, the immune system response, how H. pylori evade the immune system and treatments of the bacterial infection.  H. pylori is a gram-negative, flagellated bacteria that colonizes the human gastric mucosa and is strongly associated with gastric ulcers and duodenal ulcers.

Figure 1: Helicobacter pylori.

Figure 2: Diseases caused by Helicobacter pylori.

5 interesting facts about Helicobacter pylori:
1.  50-75% if the world population is infected with H. pylori (not all experience ulcers)
2.  Most cases of peptic ulcers and gastritis are cause by H. pylori
3.  Only known pathogen that can exist in the highly acidic region of the stomach
4.  Not until 1980s that most scientists realized that H. pylori cause ulcers (not stress or spicy foods)
5.  Gram negative bacteria whose LPS does not stimulate TLR4

These links below will provide more information on Helicobacter pylori:

Pathogen Life Cycle

Innate immune response

Humoral immune response

Cellular immune response

Evasion of immune system detection

Treatment/future directions

Contact information: