3D Structure of IDH from
This is the structure of an IDH monomer from E. coli. The large extention to the right side interacts with the other subunit to form a homodimer.
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First, let's see the substrate, isocitrate. It is shown in a ball and stick display with CPK colors.
Zoom in on isocitrate.
Now let's look at the coenzyme, NADP+. It is shown in a ball and stick display with CPK colors; isocitrate is too.
Zoom in on NADP+. Isocitrate
is below the much larger NADP +
Finally, let's see where the cofactor Mg2+ (green sphere) is located. NADP+ and isocitrate remain unchanged in appearance.
Zoom in on Mg2+.
Notice that Mg2+ is very close to isocitrate.
There are two water molecules that help position the Mg2+ in the right place to peform its function.
Let's see what all of these look like in with their Van der Waals radii displayed. See how closely isocitrate
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