Phospholipase C is a membrane associated enzyme often used to study lipid-protein interactions.  When stimulated by various hormones, phospholipase C hydrolyzes polyphosphoinositides to give second messengers such as diacyglycerol and inositol 1,4,5-triphosphate.  All isoforms of phospholipase C require the binding of a specific lipid to be able to function, regulating cellular responses.

Before viewing the nucleotide and amino acid sequences of phospholipase C from 5 eukaryotes, it would be helpful to view the structure of the molecule.  After all, the function of a molecule is often indicated by its structure.  To view a RasMol image of phospholipase C, click here.

 

Organism	Nucleotide Sequence	Amino Acid Sequence
Homo sapiens	complete cDNA	YES
Bos taurus	complete cDNA	YES
Drosophila melanogaster	complete cDNA	YES
Saccharomyces cerevisae	complete cDNA	YES
Rattus norvegicus	complete cDNA	YES