Human Genome Initiative (HGI) for High Schools

1. Goals

• What were the goals of the Human Genome Initiative?
• How is DNA sequenced?
• Compare ATP, dATP and ddATP structures (Jmol)
• Images of DNA sequencing
• Is every base important? (human gender paper)
• Is every base important? (sickle cell activity)

2. Big 7 Species:

• Human
• Mouse
• mustard weed (Arabidopsis)
• fly (Drosophila melanogaster)
• worm (Caenorhabditis elegans )
• yeast (Saccharomyces cerevisiae)
• E. coli

3. Why so many species?

4. Multi-speceis sites

• NCBI
• EBI
• TIGR
• DOE
• JGI

5. Conservation of parts: Evolution Game

• Student Instructions (PDF file)
• Teacher Instructions (Word file)
• Shapes for Game (PDF file)
• Raw Sequences (.txt file)

6. High School Human Genome Project

7. Discovery Questions with DNA Sequences

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Biology Department